P25228 · RAB3_DROME
- ProteinRas-related protein Rab-3
- GeneRab3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids220 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 30 | GTP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 33 | GTP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 34 | GTP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 35 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 35 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 36 | GTP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 47 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 48 | GTP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 52 | GTP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 53 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 53 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 79 | GTP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 134 | GTP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 137 | GTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 165 | GTP (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 166 | GTP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome | |
Cellular Component | plasma membrane | |
Cellular Component | presynaptic active zone | |
Cellular Component | synapse | |
Cellular Component | synaptic vesicle | |
Cellular Component | vesicle | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | myosin V binding | |
Biological Process | cytoskeletal matrix organization at active zone | |
Biological Process | exocytosis | |
Biological Process | maintenance of presynaptic active zone structure | |
Biological Process | neurotransmitter secretion | |
Biological Process | protein secretion | |
Biological Process | Rab protein signal transduction | |
Biological Process | regulation of neurotransmitter secretion | |
Biological Process | regulation of short-term neuronal synaptic plasticity | |
Biological Process | regulation of synaptic vesicle fusion to presynaptic active zone membrane | |
Biological Process | symbiont entry into host cell | |
Biological Process | vesicle-mediated transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRas-related protein Rab-3
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP25228
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 80 | Protein is locked into the activated GTP-bound state. | ||||
Sequence: Q → L |
PTM/Processing
Features
Showing features for chain, lipidation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000121092 | 1-220 | Ras-related protein Rab-3 | |||
Sequence: MASGGDPKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDADPTLVGGGQKGQRLTDQPQGTPNANCNC | ||||||
Lipidation | 218 | S-geranylgeranyl cysteine | ||||
Sequence: C | ||||||
Modified residue | 220 | Cysteine methyl ester | ||||
Sequence: C | ||||||
Lipidation | 220 | S-geranylgeranyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 50-58 | Effector region | ||||
Sequence: FVSTVGIDF | ||||||
Region | 194-220 | Disordered | ||||
Sequence: PTLVGGGQKGQRLTDQPQGTPNANCNC | ||||||
Compositional bias | 202-220 | Polar residues | ||||
Sequence: KGQRLTDQPQGTPNANCNC |
Sequence similarities
Belongs to the small GTPase superfamily. Rab family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length220
- Mass (Da)24,862
- Last updated1992-05-01 v1
- ChecksumB324A77DBEF847A1
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A4P7VAW6 | A0A4P7VAW6_DROME | Rab3 | 220 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 202-220 | Polar residues | ||||
Sequence: KGQRLTDQPQGTPNANCNC |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M64621 EMBL· GenBank· DDBJ | AAA28843.1 EMBL· GenBank· DDBJ | mRNA | ||
AB112932 EMBL· GenBank· DDBJ | BAD07037.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF58762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY060449 EMBL· GenBank· DDBJ | AAL25488.1 EMBL· GenBank· DDBJ | mRNA |