P25228 · RAB3_DROME

Function

function

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).

Features

Showing features for binding site.

122020406080100120140160180200220
TypeIDPosition(s)Description
Binding site30GTP (UniProtKB | ChEBI)
Binding site33GTP (UniProtKB | ChEBI)
Binding site34GTP (UniProtKB | ChEBI)
Binding site35GTP (UniProtKB | ChEBI)
Binding site35Mg2+ (UniProtKB | ChEBI)
Binding site36GTP (UniProtKB | ChEBI)
Binding site47GTP (UniProtKB | ChEBI)
Binding site48GTP (UniProtKB | ChEBI)
Binding site52GTP (UniProtKB | ChEBI)
Binding site53GTP (UniProtKB | ChEBI)
Binding site53Mg2+ (UniProtKB | ChEBI)
Binding site79GTP (UniProtKB | ChEBI)
Binding site134GTP (UniProtKB | ChEBI)
Binding site137GTP (UniProtKB | ChEBI)
Binding site165GTP (UniProtKB | ChEBI)
Binding site166GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome
Cellular Componentplasma membrane
Cellular Componentpresynaptic active zone
Cellular Componentsynapse
Cellular Componentsynaptic vesicle
Cellular Componentvesicle
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmagnesium ion binding
Molecular Functionmyosin V binding
Biological Processcytoskeletal matrix organization at active zone
Biological Processexocytosis
Biological Processmaintenance of presynaptic active zone structure
Biological Processneurotransmitter secretion
Biological Processprotein secretion
Biological ProcessRab protein signal transduction
Biological Processregulation of neurotransmitter secretion
Biological Processregulation of short-term neuronal synaptic plasticity
Biological Processregulation of synaptic vesicle fusion to presynaptic active zone membrane
Biological Processsymbiont entry into host cell
Biological Processvesicle-mediated transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras-related protein Rab-3

Gene names

    • Name
      Rab3
    • ORF names
      CG7576

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P25228
  • Secondary accessions
    • Q9V5N9

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis80Protein is locked into the activated GTP-bound state.

PTM/Processing

Features

Showing features for chain, lipidation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001210921-220
Lipidation218S-geranylgeranyl cysteine
Modified residue220Cysteine methyl ester
Lipidation220S-geranylgeranyl cysteine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with Rph.

Protein-protein interaction databases

Family & Domains

Features

Showing features for motif, region, compositional bias.

TypeIDPosition(s)Description
Motif50-58Effector region
Region194-220Disordered
Compositional bias202-220Polar residues

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    220
  • Mass (Da)
    24,862
  • Last updated
    1992-05-01 v1
  • Checksum
    B324A77DBEF847A1
MASGGDPKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDADPTLVGGGQKGQRLTDQPQGTPNANCNC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4P7VAW6A0A4P7VAW6_DROMERab3220

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias202-220Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M64621
EMBL· GenBank· DDBJ
AAA28843.1
EMBL· GenBank· DDBJ
mRNA
AB112932
EMBL· GenBank· DDBJ
BAD07037.1
EMBL· GenBank· DDBJ
mRNA
AE013599
EMBL· GenBank· DDBJ
AAF58762.1
EMBL· GenBank· DDBJ
Genomic DNA
AY060449
EMBL· GenBank· DDBJ
AAL25488.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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