P25171 · RCC1_DROME
- ProteinRegulator of chromosome condensation
- GeneRcc1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids547 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to chromatin.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | condensed chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Biological Process | cell division | |
Biological Process | central nervous system development | |
Biological Process | NLS-bearing protein import into nucleus | |
Biological Process | regulation of mitotic cell cycle | |
Biological Process | regulation of neurogenesis | |
Biological Process | regulation of nucleocytoplasmic transport | |
Biological Process | ventral cord development |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRegulator of chromosome condensation
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP25171
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000206633 | 1-547 | Regulator of chromosome condensation | |||
Sequence: MPRRKALTNNNNAGEAEQQPPKAKRARIAFHLELPKRRTVLGNVLVCGNGDVGQLGLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQDQKENVPVKVSGSSSISKKDKTPPQDNVDKEAENVDKQEQKENLPAKASTSSKKNKTPPQDNADKEAENVDKQEQKENLPAKASTSSKKIKTPPQDDAAEEVEEESAQEPTPKKAKKPAAKRGGKKT | ||||||
Modified residue | 286 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 512 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 526 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 531 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | ||||
Sequence: MPRRKALTNNNNAGEAE | ||||||
Region | 1-24 | Disordered | ||||
Sequence: MPRRKALTNNNNAGEAEQQPPKAK | ||||||
Repeat | 41-91 | RCC1 1 | ||||
Sequence: LGNVLVCGNGDVGQLGLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTK | ||||||
Repeat | 92-143 | RCC1 2 | ||||
Sequence: SGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLE | ||||||
Repeat | 145-195 | RCC1 3 | ||||
Sequence: GRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTT | ||||||
Repeat | 197-257 | RCC1 4 | ||||
Sequence: GKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRE | ||||||
Repeat | 260-310 | RCC1 5 | ||||
Sequence: TQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTT | ||||||
Repeat | 311-362 | RCC1 6 | ||||
Sequence: DLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTI | ||||||
Repeat | 363-416 | RCC1 7 | ||||
Sequence: DGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVK | ||||||
Repeat | 417-454 | Bj1 1 | ||||
Sequence: ADKQDQKENVPVKVSGSSSISKKDKTPPQDNVDKEAEN | ||||||
Region | 423-547 | Disordered | ||||
Sequence: KENVPVKVSGSSSISKKDKTPPQDNVDKEAENVDKQEQKENLPAKASTSSKKNKTPPQDNADKEAENVDKQEQKENLPAKASTSSKKIKTPPQDDAAEEVEEESAQEPTPKKAKKPAAKRGGKKT | ||||||
Compositional bias | 426-441 | Polar residues | ||||
Sequence: VPVKVSGSSSISKKDK | ||||||
Compositional bias | 442-463 | Basic and acidic residues | ||||
Sequence: TPPQDNVDKEAENVDKQEQKEN | ||||||
Repeat | 455-489 | Bj1 2 | ||||
Sequence: VDKQEQKENLPAKASTSSKKNKTPPQDNADKEAEN | ||||||
Compositional bias | 478-498 | Basic and acidic residues | ||||
Sequence: PPQDNADKEAENVDKQEQKEN | ||||||
Repeat | 490-519 | Bj1 3 | ||||
Sequence: VDKQEQKENLPAKASTSSKKIKTPPQDDAA |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length547
- Mass (Da)58,851
- Last updated2001-06-01 v2
- Checksum77D9744EBAF4597A
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | ||||
Sequence: MPRRKALTNNNNAGEAE | ||||||
Compositional bias | 426-441 | Polar residues | ||||
Sequence: VPVKVSGSSSISKKDK | ||||||
Compositional bias | 442-463 | Basic and acidic residues | ||||
Sequence: TPPQDNVDKEAENVDKQEQKEN | ||||||
Compositional bias | 478-498 | Basic and acidic residues | ||||
Sequence: PPQDNADKEAENVDKQEQKEN | ||||||
Sequence conflict | 490 | in Ref. 1; CAA41417 | ||||
Sequence: V → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X58530 EMBL· GenBank· DDBJ | CAA41417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF50726.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF50727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAN12235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY070540 EMBL· GenBank· DDBJ | AAL48011.1 EMBL· GenBank· DDBJ | mRNA |