P25171 · RCC1_DROME

Function

function

Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to chromatin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcondensed chromosome
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular Functionguanyl-nucleotide exchange factor activity
Biological Processcell division
Biological Processcentral nervous system development
Biological ProcessNLS-bearing protein import into nucleus
Biological Processregulation of mitotic cell cycle
Biological Processregulation of neurogenesis
Biological Processregulation of nucleocytoplasmic transport
Biological Processventral cord development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Regulator of chromosome condensation
  • Alternative names
    • Chromatin-binding protein Bj1
    • Regulator of chromosome condensation 1 ortholog

Gene names

    • Name
      Rcc1
    • Synonyms
      Bj1
    • ORF names
      CG10480

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P25171
  • Secondary accessions
    • A4V1J1
    • Q9VRR5

Proteomes

Organism-specific databases

Subcellular Location

Note: Becomes dispersed throughout the cytoplasm during mitosis. Is associated with chromatin throughout mitosis.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002066331-547Regulator of chromosome condensation
Modified residue286Phosphothreonine
Modified residue512Phosphothreonine
Modified residue526Phosphoserine
Modified residue531Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

    • FBgn0002638Expressed in cleaving embryo and 47 other cell types or tissues

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, repeat.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Region1-24Disordered
Repeat41-91RCC1 1
Repeat92-143RCC1 2
Repeat145-195RCC1 3
Repeat197-257RCC1 4
Repeat260-310RCC1 5
Repeat311-362RCC1 6
Repeat363-416RCC1 7
Repeat417-454Bj1 1
Region423-547Disordered
Compositional bias426-441Polar residues
Compositional bias442-463Basic and acidic residues
Repeat455-489Bj1 2
Compositional bias478-498Basic and acidic residues
Repeat490-519Bj1 3

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    547
  • Mass (Da)
    58,851
  • Last updated
    2001-06-01 v2
  • Checksum
    77D9744EBAF4597A
MPRRKALTNNNNAGEAEQQPPKAKRARIAFHLELPKRRTVLGNVLVCGNGDVGQLGLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQDQKENVPVKVSGSSSISKKDKTPPQDNVDKEAENVDKQEQKENLPAKASTSSKKNKTPPQDNADKEAENVDKQEQKENLPAKASTSSKKIKTPPQDDAAEEVEEESAQEPTPKKAKKPAAKRGGKKT

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Compositional bias426-441Polar residues
Compositional bias442-463Basic and acidic residues
Compositional bias478-498Basic and acidic residues
Sequence conflict490in Ref. 1; CAA41417

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X58530
EMBL· GenBank· DDBJ
CAA41417.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAF50726.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAF50727.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAN12235.1
EMBL· GenBank· DDBJ
Genomic DNA
AY070540
EMBL· GenBank· DDBJ
AAL48011.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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