P25127 · MT_ESOLU

Function

function

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Features

Showing features for binding site.

16051015202530354045505560
MDPCECSKTGSCNCGGSCKCSNCACTSCKKSCCSCCPSGCSKCASGCICKGKTCDTSCCQ
TypeIDPosition(s)Description
Binding site4a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site6a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site6a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site12a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site14a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site14a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site18a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site20a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site23a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site23a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site25a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site28a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site32a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site33a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site33a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site35a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site36a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site36a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site40a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site43a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site43a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site47a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site49a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site49a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site54a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site58a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site59a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site59a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionmetal ion binding
Biological Processangiogenesis
Biological Processpositive regulation of cell migration involved in sprouting angiogenesis
Biological Processpositive regulation of vascular endothelial growth factor production
Biological Processresponse to cadmium ion
Biological Processresponse to copper ion
Biological Processresponse to methylmercury
Biological Processresponse to zinc ion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Metallothionein
  • Short names
    MT

Gene names

    • Name
      mt

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Esociformes > Esocidae > Esox

Accessions

  • Primary accession
    P25127

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001972831-60Metallothionein

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-28Beta
Region29-60Alpha

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    60
  • Mass (Da)
    5,979
  • Last updated
    1992-05-01 v1
  • Checksum
    9EA1E43F95F8D97E
MDPCECSKTGSCNCGGSCKCSNCACTSCKKSCCSCCPSGCSKCASGCICKGKTCDTSCCQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59392
EMBL· GenBank· DDBJ
CAA42035.1
EMBL· GenBank· DDBJ
mRNA
X70042
EMBL· GenBank· DDBJ
CAA49636.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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