P25118 · TNR1A_MOUSE

  • Protein
    Tumor necrosis factor receptor superfamily member 1A
  • Gene
    Tnfrsf1a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentcell surface
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentprotein-containing complex
Cellular Componentreceptor complex
Molecular Functionprotease binding
Molecular Functionprotein-containing complex binding
Molecular Functionsignaling receptor activity
Molecular Functiontumor necrosis factor binding
Molecular Functiontumor necrosis factor receptor activity
Biological Processaortic valve development
Biological Processcell surface receptor signaling pathway
Biological Processcellular response to mechanical stimulus
Biological Processcytokine-mediated signaling pathway
Biological Processdefense response
Biological Processdefense response to bacterium
Biological Processextrinsic apoptotic signaling pathway via death domain receptors
Biological Processinflammatory response
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of cardiac muscle hypertrophy
Biological Processnegative regulation of extracellular matrix constituent secretion
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of interleukin-6 production
Biological Processpositive regulation of amide metabolic process
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of apoptotic process involved in morphogenesis
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of execution phase of apoptosis
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of lipid metabolic process
Biological Processpositive regulation of neuron apoptotic process
Biological Processpositive regulation of protein import into nucleus
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processprostaglandin metabolic process
Biological Processprotein localization to plasma membrane
Biological Processpulmonary valve development
Biological Processregulation of apoptotic process
Biological Processregulation of establishment of endothelial barrier
Biological Processregulation of membrane lipid metabolic process
Biological Processregulation of tumor necrosis factor-mediated signaling pathway
Biological Processtranscription by RNA polymerase II
Biological Processtumor necrosis factor-mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tumor necrosis factor receptor superfamily member 1A
  • Alternative names
    • Tumor necrosis factor receptor 1 (TNF-R1)
    • Tumor necrosis factor receptor type I (TNF-RI; TNFR-I)
    • p55
    • p60
  • CD Antigen Name
    • CD120a

Gene names

    • Name
      Tnfrsf1a
    • Synonyms
      Tnfr-1, Tnfr1

Organism names

  • Taxonomic identifier
  • Strain
    • C3H/He
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P25118

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain30-212Extracellular
Transmembrane213-235Helical
Topological domain236-454Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-29
ChainPRO_000003454530-454Tumor necrosis factor receptor superfamily member 1A
Disulfide bond44↔58
Glycosylation54N-linked (GlcNAc...) asparagine
Disulfide bond59↔72
Disulfide bond62↔81
Disulfide bond84↔99
Disulfide bond102↔117
Disulfide bond105↔125
Disulfide bond127↔143
Disulfide bond146↔158
Disulfide bond149↔166
Glycosylation151N-linked (GlcNAc...) asparagine
Disulfide bond168↔179
Disulfide bond182↔195
Disulfide bond185↔191
Glycosylation202N-linked (GlcNAc...) asparagine
Glycosylation376(Microbial infection) N-beta-linked (GlcNAc) arginine

Post-translational modification

(Microbial infection) Glycosylated at Arg-376 by S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP (By similarity).
Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (PubMed:24440909).
Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process (By similarity).
Interacts with PGLYRP1; this interaction is important for cell death induction (By similarity).
Interacts (via death domain) with MADD (via death domain) (By similarity).

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat, region, domain.

TypeIDPosition(s)Description
Repeat43-82TNFR-Cys 1
Repeat83-125TNFR-Cys 2
Repeat126-166TNFR-Cys 3
Repeat167-196TNFR-Cys 4
Region339-349N-SMase activation domain (NSD)
Domain356-441Death

Domain

Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    454
  • Mass (Da)
    50,130
  • Last updated
    1992-05-01 v1
  • Checksum
    0710C2E8C3C2B6D9
MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F6R6K0F6R6K0_MOUSETnfrsf1a107
D3YXL4D3YXL4_MOUSETnfrsf1a65
F7A4X5F7A4X5_MOUSETnfrsf1a295

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict394in Ref. 6; AAA40465

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M60468
EMBL· GenBank· DDBJ
AAA39751.1
EMBL· GenBank· DDBJ
mRNA
M59377
EMBL· GenBank· DDBJ
AAA40464.1
EMBL· GenBank· DDBJ
mRNA
X59238
EMBL· GenBank· DDBJ
CAA41922.1
EMBL· GenBank· DDBJ
mRNA
X57796
EMBL· GenBank· DDBJ
CAA40936.1
EMBL· GenBank· DDBJ
mRNA
L26349
EMBL· GenBank· DDBJ
AAA59361.1
EMBL· GenBank· DDBJ
mRNA
M76656
EMBL· GenBank· DDBJ
AAA40465.1
EMBL· GenBank· DDBJ
Genomic DNA
M88067
EMBL· GenBank· DDBJ
AAA40465.1
EMBL· GenBank· DDBJ
Genomic DNA
M76655
EMBL· GenBank· DDBJ
AAA40465.1
EMBL· GenBank· DDBJ
Genomic DNA
BC004599
EMBL· GenBank· DDBJ
AAH04599.1
EMBL· GenBank· DDBJ
mRNA
BC052675
EMBL· GenBank· DDBJ
AAH52675.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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