P25073 · TEG5_EHV4

Function

function

Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Also plays a role in the primary envelopment of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.

Miscellaneous

Expressed in late in the infection.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Cellular Componentviral tegument
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tegument protein UL47 homolog
  • Alternative names
    • GP10

Gene names

    • Name
      13
    • Synonyms
      B6

Organism names

Accessions

  • Primary accession
    P25073

Subcellular Location

Virion tegument
Host nucleus
Host cytoplasm
Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001160791-872Tegument protein UL47 homolog

Post-translational modification

Phosphorylated by US3. This phosphorylation is required for proper nuclear localization.
O-glycosylated.

Keywords

Expression

Keywords

Interaction

Subunit

Interacts with US3 kinase. Interacts with UL31 and UL34; these interactions seem important for efficient virion nuclear egress. Interacts with UL41/VHS.

Family & Domains

Features

Showing features for compositional bias, region, motif.

TypeIDPosition(s)Description
Compositional bias1-24Basic and acidic residues
Region1-206Disordered
Motif13-33Nuclear localization signal
Compositional bias26-43Polar residues
Compositional bias58-83Polar residues
Compositional bias111-128Acidic residues
Compositional bias179-200Acidic residues

Domain

The nuclear export signal is CRM1-dependent.

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    872
  • Mass (Da)
    97,377
  • Last updated
    1992-05-01 v1
  • Checksum
    1F07FFD6AFD6430D
MDQHHGVRGGAPIRRPRRSIETRSHPFRAAGNTQRTYSTPRLSYRDGLSGRASSLEPGGQAHDQNESSTQSTSNNQPSTSFWGYLRRVFSDDAPAQPQAPRSRADFAPPPEEDSSSEEEDEEGPSQAPLDEEDQLMYADQYSVGNSSDDNEEDYLQPEVEYPTSAESGEYHNSGMFAEEEPESESESDMENYETYEENDTEVISDDSHRLTRTWLDRSIRLMDDALAQSSEISKAITKSTRRLYDSQFTPGGRGYKQTETPSQRLVHLSRAGMYDSDEIVMTGDYMEVDDDPNSAYQSWVRAIHHPVAMNPSWEETISNHTNTSFSADIDYDIDELIEMNLARTPPVFEGLLDSADFFYRLPMLYTYATITQDEAYEERQAWSNTQALHGHEQSSWPALVSDYSKGGMYVSPTQEPRGIWRRALKQAMALQLKLCVLGLTEFVTKRELTQHHSAVTFLVDSLLRTAKNCYLASRLLVFAWERRRETGVRRPAEPLIALSGVTLLQPLPPEVSELLEQRTFDIGLRTPQSGVFRAFFGPLVYWAELRRALRDPAAINCRYVGFHLQTSEIYLLARAHSASPGYTKEELVAMEATLTLGTLMLEVALQWIHVASAQLLSENDALKAFRRVSASIPHALAPLGSIRLHDAEFEVLSNPDVMVARDETALSQALFLGYFSVRTALTACMRDYANEVDGGSKETVTGLFLGVGLIIQRLAGHMNFLLNCMAGAALYGGSKIAIHSLTLPRYSLLADVMAPMLQQQSLVDFWRARDDMLEELEITPRPGPPTQGKRVVLEMPLPSDDLPAMTPSGQVNNGAGLGRMVDMAKHLQHYRETIIGDDASSSVGKRGLMKSGVGVRHALEAEKVIRYSPKST

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-24Basic and acidic residues
Compositional bias26-43Polar residues
Compositional bias58-83Polar residues
Compositional bias111-128Acidic residues
Compositional bias179-200Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X17684
EMBL· GenBank· DDBJ
CAA35672.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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