P24896 · NU5M_CAEEL

  • Protein
    NADH-ubiquinone oxidoreductase chain 5
  • Gene
    nduo-5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 5

Gene names

    • Name
      nduo-5
    • Synonyms
      nd5
    • ORF names
      MTCE.35

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Bristol N2
    • AB1
    • AB2
    • CB4852
    • CB4853
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P24896

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane3-23Helical
Transmembrane43-63Helical
Transmembrane75-95Helical
Transmembrane98-118Helical
Transmembrane141-161Helical
Transmembrane168-188Helical
Transmembrane197-217Helical
Transmembrane226-246Helical
Transmembrane263-283Helical
Transmembrane318-338Helical
Transmembrane357-377Helical
Transmembrane398-418Helical
Transmembrane432-452Helical
Transmembrane507-527Helical

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant94in strain: CB4854

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001180721-527NADH-ubiquinone oxidoreductase chain 5

Proteomic databases

Expression

Gene expression databases

    • WBGene00010967Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    527
  • Mass (Da)
    61,156
  • Last updated
    1995-11-01 v2
  • Checksum
    8B804E4E0FF1EF72
MNISIFLIGFVFFMGGISVWLMPTFKLGIFFLEWDFLSLKFNFYFNSILFSFILFLVTFSVLVFSTYYLNSELNFNYYYFVLLIFVGSMFSLNFSNSIFTMLLSWDLLGISSFFLVLFYNNWDSCSGAMNTALTNRLGDYFMFVFFGLSVFSGYYFLSFSMFSSYMSLLLLLTAFTKSAQFPFSSWLPKAMSAPTPVSSLVHSSTLVTAGLILLMNFNNLVMQKDFISFVLIIGLFTMFFSSLASLVEEDLKKVVALSTLSQMGFSMVTLGLGLSFISFIHLVSHALFKSCLFMQVGYIIHCSFGQQDGRNYSNNGNLPNFIQLQMLVTLFCLCGLIFSSGAVSKDFILELFFSNNYMMFFSLMFFVSVFLTFGYSFRLWKSFFLSFNKVMNHYSSTVFMNFLSLVLVIFSISFLWWMNFNLLNIPSLFLYVDFFGPLVFLFMMIFLSFLILKMLFKELMYKFLVDYLAKNSIYKMKNLKFMDLFLNNINSKGYTLFLSSGMFKNYYLKSLNFNSVVVLIFIFFMIC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X54252
EMBL· GenBank· DDBJ
CAA38162.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171208
EMBL· GenBank· DDBJ
AAO16356.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171209
EMBL· GenBank· DDBJ
AAO16358.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171210
EMBL· GenBank· DDBJ
AAO16360.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171211
EMBL· GenBank· DDBJ
AAO16362.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171212
EMBL· GenBank· DDBJ
AAO16364.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171213
EMBL· GenBank· DDBJ
AAO16366.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171214
EMBL· GenBank· DDBJ
AAO16368.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171215
EMBL· GenBank· DDBJ
AAO16370.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171216
EMBL· GenBank· DDBJ
AAO16372.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171217
EMBL· GenBank· DDBJ
AAO16374.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171218
EMBL· GenBank· DDBJ
AAO16376.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171219
EMBL· GenBank· DDBJ
AAO16378.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171220
EMBL· GenBank· DDBJ
AAO16380.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171221
EMBL· GenBank· DDBJ
AAO16382.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171222
EMBL· GenBank· DDBJ
AAO16384.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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