P24894 · COX2_CAEEL

  • Protein
    Cytochrome c oxidase subunit 2
  • Gene
    ctc-2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a dinuclear copper A center per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site164Cu cation A1 (UniProtKB | ChEBI)
Binding site199Cu cation A1 (UniProtKB | ChEBI)
Binding site199Cu cation A2 (UniProtKB | ChEBI)
Binding site201Cu cation A2 (UniProtKB | ChEBI)
Binding site201Mg2+ (UniProtKB | ChEBI); ligand shared with subunit 1
Binding site203Cu cation A1 (UniProtKB | ChEBI)
Binding site203Cu cation A2 (UniProtKB | ChEBI)
Binding site207Cu cation A2 (UniProtKB | ChEBI)
Binding site210Cu cation A1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2
  • EC number
  • Alternative names
    • Cytochrome c oxidase polypeptide II

Gene names

    • Name
      ctc-2
    • Synonyms
      coII
      , cox-2
    • ORF names
      MTCE.31

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • AB1
    • AB2
    • Bristol N2
    • CB4852
    • CB4853
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P24894

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-30Mitochondrial intermembrane
Transmembrane31-52Helical
Topological domain53-69Mitochondrial matrix
Transmembrane70-89Helical
Topological domain90-231Mitochondrial intermembrane

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant132in strain: PB303
Natural variant143in strain: CB4857
Natural variant186in strain: AB2, CB4852, CB4853, CB4855, CB4858 and PB306
Natural variant216in strain: AB1 and KR314

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001835261-231Cytochrome c oxidase subunit 2

Proteomic databases

Expression

Gene expression databases

    • WBGene00010965Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    231
  • Mass (Da)
    26,549
  • Last updated
    1995-11-01 v2
  • Checksum
    FCD8D458D1B0DDAA
MNNFFQGYNLLFQHSLFASYMDWFHSFNCSLLLGVLVFVTLLFGYLIFGTFYFKSKKIEYQFGELLCSIFPTIILLMQMVPSLSLLYYYGLMNLDSNLTVKVTGHQWYWSYEYSDIPGLEFDSYMKSLDQLSLGEPRLLEVDNRCVIPCDTNIRFCITSADVIHAWALNSLSVKLDAMSGILSTFSYSFPMVGVFYGQCSEICGANHSFMPIALEVTLLDNFKSWCFGTME

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY171193
EMBL· GenBank· DDBJ
AAO16253.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171194
EMBL· GenBank· DDBJ
AAO16257.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171195
EMBL· GenBank· DDBJ
AAO16261.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171196
EMBL· GenBank· DDBJ
AAO16265.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171197
EMBL· GenBank· DDBJ
AAO16269.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171198
EMBL· GenBank· DDBJ
AAO16273.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171199
EMBL· GenBank· DDBJ
AAO16277.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171200
EMBL· GenBank· DDBJ
AAO16281.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171201
EMBL· GenBank· DDBJ
AAO16285.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171202
EMBL· GenBank· DDBJ
AAO16289.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171203
EMBL· GenBank· DDBJ
AAO16293.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171204
EMBL· GenBank· DDBJ
AAO16297.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171205
EMBL· GenBank· DDBJ
AAO16301.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171206
EMBL· GenBank· DDBJ
AAO16305.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171207
EMBL· GenBank· DDBJ
AAO16309.1
EMBL· GenBank· DDBJ
Genomic DNA
X54252
EMBL· GenBank· DDBJ
CAA38160.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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