P24886 · NU4LM_CAEEL

  • Protein
    NADH-ubiquinone oxidoreductase chain 4L
  • Gene
    ndfl-4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4L
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 4L

Gene names

    • Name
      ndfl-4
    • Synonyms
      nd4l
    • ORF names
      MTCE.4

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • AB1
    • AB2
    • Bristol N2
    • CB4852
    • CB4853
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P24886

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-37Helical
Transmembrane44-64Helical

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant41in strain: PB303
Natural variant70in strain: CB4855

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001184011-77NADH-ubiquinone oxidoreductase chain 4L

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 4L family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    77
  • Mass (Da)
    9,249
  • Last updated
    2003-04-11 v2
  • Checksum
    F123ECE07D07A829
MMFLFVSLFMFIFKWQRLIFILISLEFMMLSLFLKFSYVLGEMMFFYFMCFSVISSILGMVVMVGNMKFFGSDNCIF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY171133
EMBL· GenBank· DDBJ
AAO16386.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171134
EMBL· GenBank· DDBJ
AAO16389.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171135
EMBL· GenBank· DDBJ
AAO16392.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171136
EMBL· GenBank· DDBJ
AAO16395.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171137
EMBL· GenBank· DDBJ
AAO16398.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171138
EMBL· GenBank· DDBJ
AAO16401.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171139
EMBL· GenBank· DDBJ
AAO16404.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171140
EMBL· GenBank· DDBJ
AAO16407.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171141
EMBL· GenBank· DDBJ
AAO16410.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171142
EMBL· GenBank· DDBJ
AAO16413.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171143
EMBL· GenBank· DDBJ
AAO16416.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171144
EMBL· GenBank· DDBJ
AAO16419.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171145
EMBL· GenBank· DDBJ
AAO16422.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171146
EMBL· GenBank· DDBJ
AAO16425.1
EMBL· GenBank· DDBJ
Genomic DNA
AY171147
EMBL· GenBank· DDBJ
AAO16428.1
EMBL· GenBank· DDBJ
Genomic DNA
X54252
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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