P24886 · NU4LM_CAEEL
- ProteinNADH-ubiquinone oxidoreductase chain 4L
- Genendfl-4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 4L
- EC number
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionP24886
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 15-37 | Helical | |||
Transmembrane | 44-64 | Helical | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 41 | in strain: PB303 | |||
Natural variant | 70 | in strain: CB4855 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000118401 | 1-77 | NADH-ubiquinone oxidoreductase chain 4L | ||
Proteomic databases
Structure
Family & Domains
Sequence similarities
Belongs to the complex I subunit 4L family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length77
- Mass (Da)9,249
- Last updated2003-04-11 v2
- ChecksumF123ECE07D07A829
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY171133 EMBL· GenBank· DDBJ | AAO16386.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171134 EMBL· GenBank· DDBJ | AAO16389.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171135 EMBL· GenBank· DDBJ | AAO16392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171136 EMBL· GenBank· DDBJ | AAO16395.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171137 EMBL· GenBank· DDBJ | AAO16398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171138 EMBL· GenBank· DDBJ | AAO16401.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171139 EMBL· GenBank· DDBJ | AAO16404.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171140 EMBL· GenBank· DDBJ | AAO16407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171141 EMBL· GenBank· DDBJ | AAO16410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171142 EMBL· GenBank· DDBJ | AAO16413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171143 EMBL· GenBank· DDBJ | AAO16416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171144 EMBL· GenBank· DDBJ | AAO16419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171145 EMBL· GenBank· DDBJ | AAO16422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171146 EMBL· GenBank· DDBJ | AAO16425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY171147 EMBL· GenBank· DDBJ | AAO16428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X54252 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |