P24763 · PG166_VACCW
- ProteinProtein OPG166
- GeneOPG166
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids277 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Promotes, when overexpressed, the influx of extracellular Ca2+, leading to membrane permeability and host cell necrosis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular exosome | |
Cellular Component | host cell membrane | |
Cellular Component | plasma membrane | |
Molecular Function | thrombospondin receptor activity | |
Biological Process | positive regulation of cell-cell adhesion | |
Biological Process | positive regulation of inflammatory response | |
Biological Process | positive regulation of phagocytosis |
Names & Taxonomy
Protein names
- Recommended nameProtein OPG166
Gene names
Organism names
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Nucleocytoviricota > Pokkesviricetes > Chitovirales > Poxviridae > Chordopoxvirinae > Orthopoxvirus > Vaccinia virus
- Virus hosts
Accessions
- Primary accessionP24763
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 124-144 | Helical | ||||
Sequence: TMLMFIFTGITLFLLFLEITY | ||||||
Transmembrane | 156-176 | Helical | ||||
Sequence: GILQVFGCVIAMIELCGAFLF | ||||||
Transmembrane | 186-206 | Helical | ||||
Sequence: IIGLLMMTLPSIFLIITKVFS | ||||||
Transmembrane | 219-239 | Helical | ||||
Sequence: LIIYYQLAGYILTVLGLGLSL | ||||||
Transmembrane | 247-267 | Helical | ||||
Sequence: LLLSGLGTIMVSEHFSLLFLV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000099325 | 1-277 | Protein OPG166 | |||
Sequence: MSRVRISLIYLCTFMIITSTKTIEYTACNNTIIIPCTIDNPTKYIRWKLDNHDILTYNKTSKTTILSKWHTSARLHSLSDSDVSLIIEYKDILPGTYTCEDNTGIKSTVKLVQRHTNWFNDYQTMLMFIFTGITLFLLFLEITYTSISVVFSTNLGILQVFGCVIAMIELCGAFLFYPSMFTLRHIIGLLMMTLPSIFLIITKVFSFWLLCKLSCAVHLIIYYQLAGYILTVLGLGLSLKECVDGTLLLSGLGTIMVSEHFSLLFLVCFPSTQRDYY | ||||||
Glycosylation | 29 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 58 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N |
Keywords
- PTM
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)31,612
- Last updated1992-03-01 v1
- Checksum96B2EB9E9E897837
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 114 | in Ref. 3; AAO89441 | ||||
Sequence: R → L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D11079 EMBL· GenBank· DDBJ | BAA01810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M61187 EMBL· GenBank· DDBJ | AAA48334.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X57318 EMBL· GenBank· DDBJ | CAA40588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY243312 EMBL· GenBank· DDBJ | AAO89441.1 EMBL· GenBank· DDBJ | Genomic DNA |