P24534 · EF1B_HUMAN

  • Protein
    Elongation factor 1-beta
  • Gene
    EEF1B2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componenteukaryotic translation elongation factor 1 complex
Molecular Functionguanyl-nucleotide exchange factor activity
Molecular Functiontranslation elongation factor activity
Biological Processtranslational elongation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 1-beta
  • Short names
    EF-1-beta

Gene names

    • Name
      EEF1B2
    • Synonyms
      EEF1B, EF1B

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P24534
  • Secondary accessions
    • A8K795
    • Q6IBH9

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 458 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue, modified residue (large scale data), cross-link.

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
ChainPRO_00001550212-225UniProtElongation factor 1-beta
Modified residue7UniProtN6-acetyllysine
Modified residue8UniProtPhosphoserine
Modified residue (large scale data)8PRIDEPhosphoserine
Modified residue (large scale data)31PRIDEPhosphoserine
Modified residue42UniProtPhosphoserine
Modified residue (large scale data)42PRIDEPhosphoserine
Modified residue (large scale data)43PRIDEPhosphoserine
Modified residue88UniProtPhosphothreonine
Modified residue (large scale data)88PRIDEPhosphothreonine
Modified residue (large scale data)90PRIDEPhosphoserine
Modified residue93UniProtPhosphothreonine
Modified residue (large scale data)93PRIDEPhosphothreonine
Modified residue95UniProtPhosphoserine
Modified residue (large scale data)95PRIDEPhosphoserine
Modified residue106UniProtPhosphoserine
Modified residue (large scale data)106PRIDEPhosphoserine
Modified residue (large scale data)112PRIDEPhosphoserine
Modified residue (large scale data)141PRIDEPhosphoserine
Cross-link147UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue174UniProtPhosphoserine
Modified residue (large scale data)174PRIDEPhosphoserine
Modified residue (large scale data)175PRIDEPhosphoserine
Modified residue (large scale data)182PRIDEPhosphotyrosine

Post-translational modification

Phosphorylation affects the GDP/GTP exchange rate.

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Induction

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.

Gene expression databases

Organism-specific databases

Interaction

Subunit

EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain2-84GST C-terminal
Region78-115Disordered

Sequence similarities

Belongs to the EF-1-beta/EF-1-delta family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    24,764
  • Last updated
    2007-01-23 v3
  • Checksum
    CDE763ADBF127822
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGSGATDSKDDDDIDLFGSDDEEESEEAKRLREERLAQYESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WFC9F8WFC9_HUMANEEF1B268
F8WF65F8WF65_HUMANEEF1B229
C9JZW3C9JZW3_HUMANEEF1B2123
F2Z2G2F2Z2G2_HUMANEEF1B268

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X60489
EMBL· GenBank· DDBJ
CAA43019.1
EMBL· GenBank· DDBJ
mRNA
X60656
EMBL· GenBank· DDBJ
CAA43063.1
EMBL· GenBank· DDBJ
mRNA
BT007079
EMBL· GenBank· DDBJ
AAP35742.1
EMBL· GenBank· DDBJ
mRNA
CR456825
EMBL· GenBank· DDBJ
CAG33106.1
EMBL· GenBank· DDBJ
mRNA
AK291910
EMBL· GenBank· DDBJ
BAF84599.1
EMBL· GenBank· DDBJ
mRNA
AC007383
EMBL· GenBank· DDBJ
AAY15062.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471063
EMBL· GenBank· DDBJ
EAW70381.1
EMBL· GenBank· DDBJ
Genomic DNA
BC000211
EMBL· GenBank· DDBJ
AAH00211.1
EMBL· GenBank· DDBJ
mRNA
BC004931
EMBL· GenBank· DDBJ
AAH04931.1
EMBL· GenBank· DDBJ
mRNA
BC067787
EMBL· GenBank· DDBJ
AAH67787.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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