P24472 · GSTA4_MOUSE
- ProteinGlutathione S-transferase A4
- GeneGsta4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids222 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Miscellaneous
On the basis of immunological and kinetics data, GST 5.7 is distinct from alpha, mu and pI classes of GTS. However it has been postulated that this protein may be part of a distinct subgroup within this alpha class.
The variations were found from AA sequencing and imply there are multiple forms of this protein. These variations are likely to be sex-linked and tissue specific.
Catalytic activity
- glutathione + RX = a halide anion + an S-substituted glutathione + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | glutathione transferase activity | |
Molecular Function | organic cyclic compound binding | |
Molecular Function | toxic substance binding | |
Biological Process | glutathione metabolic process | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione S-transferase A4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP24472
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 115 | requires 2 nucleotide substitutions | ||||
Sequence: K → P | ||||||
Natural variant | 167 | |||||
Sequence: V → G | ||||||
Natural variant | 179-180 | |||||
Sequence: PL → GE |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000185791 | 1-222 | Glutathione S-transferase A4 | |||
Sequence: MAAKPKLYYFNGRGRMESIRWLLAAAGVEFEEEFLETREQYEKMQKDGHLLFGQVPLVEIDGMMLTQTRAILSYLAAKYNLYGKDLKERVRIDMYADGTQDLMMMIAVAPFKTPKEKEESYDLILSRAKTRYFPVFEKILKDHGEAFLVGNQLSWADIQLLEAILMVEELSAPVLSDFPLLQAFKTRISNIPTIKKFLQPGSQRKPPPDGPYVEVVRTVLKF |
Post-translational modification
The N-terminus is blocked.
Keywords
- PTM
Proteomic databases
2D gel databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-83 | GST N-terminal | ||||
Sequence: AKPKLYYFNGRGRMESIRWLLAAAGVEFEEEFLETREQYEKMQKDGHLLFGQVPLVEIDGMMLTQTRAILSYLAAKYNLYG | ||||||
Domain | 85-208 | GST C-terminal | ||||
Sequence: DLKERVRIDMYADGTQDLMMMIAVAPFKTPKEKEESYDLILSRAKTRYFPVFEKILKDHGEAFLVGNQLSWADIQLLEAILMVEELSAPVLSDFPLLQAFKTRISNIPTIKKFLQPGSQRKPPP |
Sequence similarities
Belongs to the GST superfamily. Alpha family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length222
- Mass (Da)25,564
- Last updated2002-01-23 v3
- ChecksumB580E3415289424D
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1L1SS61 | A0A1L1SS61_MOUSE | Gsta4 | 105 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 36 | in Ref. 2; BAB31640 | ||||
Sequence: E → D | ||||||
Sequence conflict | 205-206 | in Ref. 2; BAB27873 | ||||
Sequence: KP → SA | ||||||
Sequence conflict | 218 | in Ref. 1; AAA37754 | ||||
Sequence: T → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L06047 EMBL· GenBank· DDBJ | AAA37754.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008189 EMBL· GenBank· DDBJ | BAB25520.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008193 EMBL· GenBank· DDBJ | BAB25524.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008400 EMBL· GenBank· DDBJ | BAB25649.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008490 EMBL· GenBank· DDBJ | BAB25696.1 EMBL· GenBank· DDBJ | mRNA | ||
AK009668 EMBL· GenBank· DDBJ | BAB26429.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010098 EMBL· GenBank· DDBJ | BAB26701.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011177 EMBL· GenBank· DDBJ | BAB27449.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011841 EMBL· GenBank· DDBJ | BAB27873.1 EMBL· GenBank· DDBJ | mRNA | ||
AK019100 EMBL· GenBank· DDBJ | BAB31546.1 EMBL· GenBank· DDBJ | mRNA | ||
AK019271 EMBL· GenBank· DDBJ | BAB31640.1 EMBL· GenBank· DDBJ | mRNA | ||
BC012639 EMBL· GenBank· DDBJ | AAH12639.1 EMBL· GenBank· DDBJ | mRNA |