P24472 · GSTA4_MOUSE

  • Protein
    Glutathione S-transferase A4
  • Gene
    Gsta4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Miscellaneous

On the basis of immunological and kinetics data, GST 5.7 is distinct from alpha, mu and pI classes of GTS. However it has been postulated that this protein may be part of a distinct subgroup within this alpha class.
The variations were found from AA sequencing and imply there are multiple forms of this protein. These variations are likely to be sex-linked and tissue specific.

Catalytic activity

Features

Showing features for binding site.

122220406080100120140160180200220
TypeIDPosition(s)Description
Binding site9glutathione (UniProtKB | ChEBI)
Binding site53-55glutathione (UniProtKB | ChEBI)
Binding site66-68glutathione (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutathione transferase activity
Molecular Functionorganic cyclic compound binding
Molecular Functiontoxic substance binding
Biological Processglutathione metabolic process
Biological Processxenobiotic metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione S-transferase A4
  • EC number
  • Alternative names
    • GST A4-4 (GSTA4-4)
    • GST class-alpha member 4
    • Glutathione S-transferase 5.7 (GST 5.7)

Gene names

    • Name
      Gsta4
    • Synonyms
      Gsta

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • CD-1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P24472
  • Secondary accessions
    • Q9CQ81
    • Q9CTY7
    • Q9CY87
    • Q9D038

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant115requires 2 nucleotide substitutions
Natural variant167
Natural variant179-180

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00001857911-222Glutathione S-transferase A4

Post-translational modification

The N-terminus is blocked.

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-83GST N-terminal
Domain85-208GST C-terminal

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    222
  • Mass (Da)
    25,564
  • Last updated
    2002-01-23 v3
  • Checksum
    B580E3415289424D
MAAKPKLYYFNGRGRMESIRWLLAAAGVEFEEEFLETREQYEKMQKDGHLLFGQVPLVEIDGMMLTQTRAILSYLAAKYNLYGKDLKERVRIDMYADGTQDLMMMIAVAPFKTPKEKEESYDLILSRAKTRYFPVFEKILKDHGEAFLVGNQLSWADIQLLEAILMVEELSAPVLSDFPLLQAFKTRISNIPTIKKFLQPGSQRKPPPDGPYVEVVRTVLKF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1L1SS61A0A1L1SS61_MOUSEGsta4105

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict36in Ref. 2; BAB31640
Sequence conflict205-206in Ref. 2; BAB27873
Sequence conflict218in Ref. 1; AAA37754

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L06047
EMBL· GenBank· DDBJ
AAA37754.1
EMBL· GenBank· DDBJ
mRNA
AK008189
EMBL· GenBank· DDBJ
BAB25520.1
EMBL· GenBank· DDBJ
mRNA
AK008193
EMBL· GenBank· DDBJ
BAB25524.1
EMBL· GenBank· DDBJ
mRNA
AK008400
EMBL· GenBank· DDBJ
BAB25649.1
EMBL· GenBank· DDBJ
mRNA
AK008490
EMBL· GenBank· DDBJ
BAB25696.1
EMBL· GenBank· DDBJ
mRNA
AK009668
EMBL· GenBank· DDBJ
BAB26429.1
EMBL· GenBank· DDBJ
mRNA
AK010098
EMBL· GenBank· DDBJ
BAB26701.1
EMBL· GenBank· DDBJ
mRNA
AK011177
EMBL· GenBank· DDBJ
BAB27449.1
EMBL· GenBank· DDBJ
mRNA
AK011841
EMBL· GenBank· DDBJ
BAB27873.1
EMBL· GenBank· DDBJ
mRNA
AK019100
EMBL· GenBank· DDBJ
BAB31546.1
EMBL· GenBank· DDBJ
mRNA
AK019271
EMBL· GenBank· DDBJ
BAB31640.1
EMBL· GenBank· DDBJ
mRNA
BC012639
EMBL· GenBank· DDBJ
AAH12639.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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