P24325 · GALE_HAEIN
- ProteinUDP-glucose 4-epimerase
- GenegalE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids338 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae.
Catalytic activity
- UDP-alpha-D-glucose = UDP-alpha-D-galactose
Cofactor
Pathway
Carbohydrate metabolism; galactose metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11-12 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 31-36 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 58-59 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 80-84 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 99 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 124 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 124 | substrate | |||
Active site | 149 | Proton acceptor | |||
Binding site | 149 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 149 | substrate | |||
Binding site | 153 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 178 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 179 | substrate | |||
Binding site | 199-200 | substrate | |||
Binding site | 216-218 | substrate | |||
Binding site | 231 | substrate | |||
Binding site | 292-295 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | UDP-glucose 4-epimerase activity | |
Biological Process | galactose catabolic process via UDP-galactose |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-glucose 4-epimerase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionP24325
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 285 | in strain: RM 7004 | |||
Natural variant | 333 | in strain: RM 7004 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
Miscellaneous
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000183205 | 1-338 | UDP-glucose 4-epimerase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length338
- Mass (Da)37,165
- Last updated1995-11-01 v2
- MD5 Checksum1CEBED27C48A1FB4213D42B6A2D50192
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X57315 EMBL· GenBank· DDBJ | CAA40568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L42023 EMBL· GenBank· DDBJ | AAC22012.1 EMBL· GenBank· DDBJ | Genomic DNA |