P24268 · CATD_RAT

Function

function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Catalytic activity

  • Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
    EC:3.4.23.5 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

140750100150200250300350400
TypeIDPosition(s)Description
Active site97
Active site290

GO annotations

AspectTerm
Cellular Componentendosome lumen
Cellular Componentendosome membrane
Cellular Componentextracellular space
Cellular ComponentGABA-ergic synapse
Cellular Componentlysosomal membrane
Cellular Componentlysosome
Cellular Componentmelanosome
Cellular Componentmembrane raft
Cellular Componentpresynaptic endosome
Molecular Functionaspartic-type endopeptidase activity
Molecular Functionaspartic-type peptidase activity
Molecular Functionendopeptidase activity
Molecular Functionhydrolase activity
Molecular Functionpeptidase activity
Molecular Functionpeptide binding
Biological Processautophagosome assembly
Biological Processinsulin catabolic process
Biological Processinsulin receptor recycling
Biological Processlipoprotein catabolic process
Biological Processpositive regulation of apoptotic process
Biological Processprotein catabolic process
Biological Processproteolysis
Biological Processregulation of establishment of protein localization
Biological Processresponse to nutrient levels
Biological Processsynaptic vesicle endosomal processing
Biological Processvesicle-mediated transport in synapse

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Ctsd

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P24268

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-20
PropeptidePRO_000002595821-64Activation peptide
ChainPRO_000002596165-117Cathepsin D 9 kDa light chain
ChainPRO_000002596065-164Cathepsin D 12 kDa light chain
ChainPRO_000002595965-407Cathepsin D
Disulfide bond91↔160
Disulfide bond110↔117
ChainPRO_0000025962118-407Cathepsin D 34 kDa heavy chain
Glycosylation134N-linked (GlcNAc...) asparagine
ChainPRO_0000025963165-407Cathepsin D 30 kDa heavy chain
Glycosylation258N-linked (GlcNAc...) asparagine
Disulfide bond281↔285
Disulfide bond324↔361

Post-translational modification

N- and O-glycosylated.
Undergoes proteolytic cleavage and activation by ADAM30.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Occurs as a mixture of both a single chain form and two types of two chain (light and heavy) forms (PubMed:1883350).
Interacts with ADAM30; this leads to activation of CTSD (By similarity).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-402Peptidase A1

Sequence similarities

Belongs to the peptidase A1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    407
  • Mass (Da)
    44,681
  • Last updated
    1992-03-01 v1
  • Checksum
    C423AD4104D95F84
MQTPGVLLLILGLLDASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNKVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AKF2A0A8I6AKF2_RATCtsd374
A6HY44A6HY44_RATCtsd407
F7F3R8F7F3R8_RATCtsd405

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict15in Ref. 2; AA sequence
Sequence conflict163in Ref. 3; AA sequence
Sequence conflict205in Ref. 2; AA sequence
Sequence conflict262in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X54467
EMBL· GenBank· DDBJ
CAA38349.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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