P24226 · HISX_BRAOC

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Miscellaneous

Cabbage may contain multiple HDH isozymes encoded by different genes.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site156NAD+ (UniProtKB | ChEBI)
Binding site218NAD+ (UniProtKB | ChEBI)
Binding site241NAD+ (UniProtKB | ChEBI)
Binding site267substrate
Binding site289substrate
Binding site289Zn2+ (UniProtKB | ChEBI)
Binding site292substrate
Binding site292Zn2+ (UniProtKB | ChEBI)
Active site357Proton acceptor
Active site358Proton acceptor
Binding site358substrate
Binding site391substrate
Binding site391Zn2+ (UniProtKB | ChEBI)
Binding site445substrate
Binding site450substrate
Binding site450Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast stroma
Cellular Componentcytosol
Molecular Functionhistidinol dehydrogenase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase, chloroplastic
  • EC number
  • Short names
    HDH

Gene names

    • Name
      HDH

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Brassiceae > Brassica

Accessions

  • Primary accession
    P24226

Subcellular Location

Phenotypes & Variants

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-31Chloroplast
ChainPRO_000000721632-469Histidinol dehydrogenase, chloroplastic

Interaction

Structure

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    469
  • Mass (Da)
    50,959
  • Last updated
    1992-03-01 v1
  • Checksum
    EC63FA4B7B2E19CA
MSFDLSRLSLTSSPRLSFLTRTATKKGFVRCSMKSYRLSELSFSQVENLKARPRIDFSSIFTTVNPIIDAVRSKGDTAVKEYTERFDKVQLNKVVEDVSELDIPELDSAVKEAFDVAYDNIYAFHFAQMSTEKSVENMKGVRCKRVSRSIGSVGLYVPGGTAVLPSTALMLAIPAQIAGCKTVVLATPPTKEGSICKEVLYCAKRAGVTHILKAGGAQAIAAMAWGTDSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADEHASPVYIAADLLSQAEHGPDSQVVLVVVGDGVNLKAIEEEIAKQCKSLPRGEFASKALSHSFTVFARDMIEAITFSNLYAPEHLIINVKDAEKWEGLIENAGSVFIGPWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKFMTVQSLTEEGLRNLGPYVATMAEIEGLDAHKRAVTLRLKDIEAKQTQTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M60466
EMBL· GenBank· DDBJ
AAA32991.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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