P23572 · CDK1_DROME
- ProteinCyclin-dependent kinase 1
- GeneCdk1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids297 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a key role in the control of the eukaryotic cell cycle (PubMed:15581871, PubMed:2120044).
Required for entry into S-phase and mitosis (PubMed:15581871, PubMed:2120044, PubMed:29746464).
In embryos, promotes the release of Rif1 from chromatin during mid-blastula transition (PubMed:29746464).
p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (PubMed:2120044).
Required for entry into S-phase and mitosis (PubMed:15581871, PubMed:2120044, PubMed:29746464).
In embryos, promotes the release of Rif1 from chromatin during mid-blastula transition (PubMed:29746464).
p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (PubMed:2120044).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Activity regulation
Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCyclin-dependent kinase 1
- EC number
- Short namesCDK1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP23572
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 43 | In cdc2-E1-4; larval-pupal lethal with some adult escapers. | ||||
Sequence: G → D | ||||||
Mutagenesis | 145 | In cdc2-216A; larval-pupal lethal. | ||||
Sequence: A → V | ||||||
Mutagenesis | 148 | In cdc2-D57; embryonic or larval-pupal lethal. | ||||
Sequence: G → R | ||||||
Mutagenesis | 176 | In cdc2-E10; larval-pupal lethal. | ||||
Sequence: L → Q | ||||||
Mutagenesis | 196 | In cdc2-E1-24; larval-pupal lethal with some adult escapers. | ||||
Sequence: E → K | ||||||
Mutagenesis | 206 | In cdc2-E1-23; larval-pupal lethal. | ||||
Sequence: G → D | ||||||
Mutagenesis | 242 | In cdc2-E1-9; larval-pupal lethal. | ||||
Sequence: P → S |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000085743 | 1-297 | Cyclin-dependent kinase 1 | |||
Sequence: MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN | ||||||
Modified residue | 14 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 15 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 160 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 161 | Phosphothreonine; by CAK | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expressed both maternally and zygotically (PubMed:2120044, PubMed:8405984).
High levels of expression when mitosis is elevated; highest levels of expression are in early embryos with levels decreasing during embryogenesis and remaining low throughout most of larval development, and expression levels are also increased in unfertilized eggs and adult females (PubMed:2120044).
High levels of expression when mitosis is elevated; highest levels of expression are in early embryos with levels decreasing during embryogenesis and remaining low throughout most of larval development, and expression levels are also increased in unfertilized eggs and adult females (PubMed:2120044).
Gene expression databases
Interaction
Subunit
Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Component of the Frs-CycA-Cdk1 complex composed of Cdk1, CycA and Z600 (PubMed:17431409).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P23572 | Cks85A Q9VHN1 | 4 | EBI-108689, EBI-122930 | |
BINARY | P23572 | CycB3 Q9I7I0 | 2 | EBI-108689, EBI-150964 | |
BINARY | P23572 | CycC P25008 | 4 | EBI-108689, EBI-195485 | |
BINARY | P23572 | CycE P54733 | 6 | EBI-108689, EBI-203549 | |
BINARY | P23572 | CycK Q961D1 | 4 | EBI-108689, EBI-130995 | |
BINARY | P23572 | twe Q03019 | 4 | EBI-108689, EBI-138996 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-287 | Protein kinase | ||||
Sequence: FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYF |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length297
- Mass (Da)34,439
- Last updated1991-11-01 v1
- Checksum952CF136D8AB64C0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X57485 EMBL· GenBank· DDBJ | CAA40723.1 EMBL· GenBank· DDBJ | mRNA | ||
X57496 EMBL· GenBank· DDBJ | CAA40733.1 EMBL· GenBank· DDBJ | mRNA | ||
S66801 EMBL· GenBank· DDBJ | AAP13986.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
S66804 EMBL· GenBank· DDBJ | AAP13987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
S66805 EMBL· GenBank· DDBJ | AAP13988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
S66807 EMBL· GenBank· DDBJ | AAP13989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
S66810 EMBL· GenBank· DDBJ | AAP13990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294319 EMBL· GenBank· DDBJ | CAL26249.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294320 EMBL· GenBank· DDBJ | CAL26250.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294321 EMBL· GenBank· DDBJ | CAL26251.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294322 EMBL· GenBank· DDBJ | CAL26252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294323 EMBL· GenBank· DDBJ | CAL26253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294324 EMBL· GenBank· DDBJ | CAL26254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294325 EMBL· GenBank· DDBJ | CAL26255.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294326 EMBL· GenBank· DDBJ | CAL26256.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294327 EMBL· GenBank· DDBJ | CAL26257.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294328 EMBL· GenBank· DDBJ | CAL26258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM294329 EMBL· GenBank· DDBJ | CAL26259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF52932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY061450 EMBL· GenBank· DDBJ | AAL28998.1 EMBL· GenBank· DDBJ | mRNA |