P23466 · CYAA_LACKL
- ProteinAdenylate cyclase
- GeneCYR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1839 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate cyclase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Lachancea
Accessions
- Primary accessionP23466
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000195732 | 1-1839 | Adenylate cyclase | |||
Sequence: MSSPTDAERVNMRREKHPQIEETFEEHVHNAMPKFKKHYALGITTHTNDEDDDPRDHRQRGIHNPNFIHSPNDPRPPLSQPIKPRFSVHGTASNASVFSHGDIAPVRKTSRAGSLFKRLAGKKSTTSLLGTEHQQRQQQQSSNSLVPAAGLRRKMSTFIHGGSGSQSNESRGTRSSIFFPSTSNSRRGSATSTMTSGSRSSHPPDTPPITSQQQEQQYDQQRQQRPETREQEQKPPTLSDMPIVSRSPSFFMLDTDLNNLSDITNIISATPKNTESDEVRSTGANKTLKYPKPPLSSHKSTSASDLSHHKAQWTAPESWDIEEDANKLLATKRKAKHHHHYHHPQHPRPPHRKHYSNFSKPIEDKAVVEKEQEPPEKCPQPISTDSNDAQGLEIAKPIDESSGIQHSASTQSVSSFSSGATGASGATGKQIGGDQETESTISTVGEDEEVTNLRSIDSEQTDDTSFSKFDEEYDKAEYQLEKYYNDFSDVDLNRRYAIRIFNIDDTFTTLSCTPNTTLQDMMPQLKRKFNVGQGSYQVSLKVGKLSKILRPTAKPILIQRRLLLLNGYLKSDPLHIMGIEDLSFIFSFVFHPVATSHLNYEQEQRLSRGDFVHVDLRNMDLTTPPIILYQHTSDIESLDVSNNANIFLPLDFIESAIKLSSLRMVNIRASKFPANVTDAYKLVSLDLERNFIKKVPDSIFKLNNLTIVNLQCNNLERLPPGFSKLKNLQLLDISSNKFVNYPEVINSCTNLLQIDLSYNKIHSLPVSINQLVKLAKMNLFNNRLTSVGDLSQMKNLRTLNLRCNRVTSIECHAPNLQNLFLTDNRISTFDDDLTRLRTLELQQNPITSMVCGGNYMANMTSLSLNKAKLSSFSAELLSKLPRLEKLELNENNLTQLPPEINKLTRLIYLSVARNKLESIPDEISDLRSLKSLDLHSNNLRMLMNNLEDLELTSLNVSSNLLTGFHGSPAKFFASPSPKLAKSLLFLSVADNNLTDSIWPLVNTFQNLKTLNLSYNNFVEISDLKLQNLTELYLSGNNFTSLPGEAVQHLRSLKVLMLNGNKLLSLPAELSQLSRLSVLDVGSNQLKYNISNYHYDWNWRNNKDLKYLNFSGNKRFEIKSALDPEGKNDLSDLGILKQLRVLGLMDVTLKTSKVPDESVSIRLRTTASMINGMRYGVADTLGQSDSVCSRDVTFERFRGREDECLICLYDGKNENASSGHKISKIIRDIYDKILIRLLEKYGEESDGIKRALRYSFLQLNKEINGMLVSVEDGNTDSGLTSADLLSGSSATVVYLKGKKIYTANIGDTMAVLSKNNGDFVTLTKLHVPAEREEYERIRTSGGYVNNQKLDGVSEVSRAVGFFDLLPHIHASPDISETVLSYSDEMLIIATHKLWEYLDYETVCDISRENKSQPMSAAEKMKDYAISYGCSDNITILCVSLDKSVNQQSQFTLNREDLISRKNTFEDTVLRRLQPEIAPPTGNVAIVFTDIKNSTFLWELFPDAMRAAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSALVWCLSVQLKLLEAEWPEEITSIQDGCLITDNSGTKVYLGLSVRMGVHWGCPVPEIDLVTQRMDYLGPVVNKAARVSGVADGGQITLSSDFCSEFKKIMKFHKRVVENQEPLKEVYGEDFIGEVLEREIHMLENVGWVFKDLGEQKLKGLETKEFITIAYPKTLASRHDLATKNQNSSVLNDDLLFQLRTISNKLENILSSINGGLIESETPGNSSIYMTFDKNTKDAVITKSTESDWISFLDHLVTRVESTVAILQLRQKLQGGLELYTSSDSTMHKSVFELLDEILKIQTDQKQ |
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Disordered | ||||
Sequence: MSSPTDAERVNMRREKHPQIE | ||||||
Compositional bias | 43-63 | Basic and acidic residues | ||||
Sequence: ITTHTNDEDDDPRDHRQRGIH | ||||||
Region | 43-87 | Disordered | ||||
Sequence: ITTHTNDEDDDPRDHRQRGIHNPNFIHSPNDPRPPLSQPIKPRFS | ||||||
Compositional bias | 126-147 | Polar residues | ||||
Sequence: TSLLGTEHQQRQQQQSSNSLVP | ||||||
Region | 126-245 | Disordered | ||||
Sequence: TSLLGTEHQQRQQQQSSNSLVPAAGLRRKMSTFIHGGSGSQSNESRGTRSSIFFPSTSNSRRGSATSTMTSGSRSSHPPDTPPITSQQQEQQYDQQRQQRPETREQEQKPPTLSDMPIVS | ||||||
Compositional bias | 159-221 | Polar residues | ||||
Sequence: IHGGSGSQSNESRGTRSSIFFPSTSNSRRGSATSTMTSGSRSSHPPDTPPITSQQQEQQYDQQ | ||||||
Region | 272-315 | Disordered | ||||
Sequence: KNTESDEVRSTGANKTLKYPKPPLSSHKSTSASDLSHHKAQWTA | ||||||
Compositional bias | 294-311 | Polar residues | ||||
Sequence: PLSSHKSTSASDLSHHKA | ||||||
Compositional bias | 332-355 | Basic residues | ||||
Sequence: KRKAKHHHHYHHPQHPRPPHRKHY | ||||||
Region | 332-388 | Disordered | ||||
Sequence: KRKAKHHHHYHHPQHPRPPHRKHYSNFSKPIEDKAVVEKEQEPPEKCPQPISTDSND | ||||||
Compositional bias | 356-376 | Basic and acidic residues | ||||
Sequence: SNFSKPIEDKAVVEKEQEPPE | ||||||
Region | 400-468 | Disordered | ||||
Sequence: ESSGIQHSASTQSVSSFSSGATGASGATGKQIGGDQETESTISTVGEDEEVTNLRSIDSEQTDDTSFSK | ||||||
Compositional bias | 402-449 | Polar residues | ||||
Sequence: SGIQHSASTQSVSSFSSGATGASGATGKQIGGDQETESTISTVGEDEE | ||||||
Compositional bias | 450-468 | Basic and acidic residues | ||||
Sequence: VTNLRSIDSEQTDDTSFSK | ||||||
Domain | 494-574 | Ras-associating | ||||
Sequence: RRYAIRIFNIDDTFTTLSCTPNTTLQDMMPQLKRKFNVGQGSYQVSLKVGKLSKILRPTAKPILIQRRLLLLNGYLKSDPL | ||||||
Repeat | 632-655 | LRR 1 | ||||
Sequence: TSDIESLDVSNNANIFLPLDFIES | ||||||
Repeat | 659-679 | LRR 2 | ||||
Sequence: LSSLRMVNIRASKFPANVTDA | ||||||
Repeat | 681-702 | LRR 3 | ||||
Sequence: KLVSLDLERNFIKKVPDSIFKL | ||||||
Repeat | 704-726 | LRR 4 | ||||
Sequence: NLTIVNLQCNNLERLPPGFSKLK | ||||||
Repeat | 727-748 | LRR 5 | ||||
Sequence: NLQLLDISSNKFVNYPEVINSC | ||||||
Repeat | 750-771 | LRR 6 | ||||
Sequence: NLLQIDLSYNKIHSLPVSINQL | ||||||
Repeat | 773-794 | LRR 7 | ||||
Sequence: KLAKMNLFNNRLTSVGDLSQMK | ||||||
Repeat | 795-816 | LRR 8 | ||||
Sequence: NLRTLNLRCNRVTSIECHAPNL | ||||||
Repeat | 817-834 | LRR 9 | ||||
Sequence: QNLFLTDNRISTFDDDLT | ||||||
Repeat | 835-856 | LRR 10 | ||||
Sequence: RLRTLELQQNPITSMVCGGNYM | ||||||
Repeat | 858-879 | LRR 11 | ||||
Sequence: NMTSLSLNKAKLSSFSAELLSK | ||||||
Repeat | 882-903 | LRR 12 | ||||
Sequence: RLEKLELNENNLTQLPPEINKL | ||||||
Repeat | 905-926 | LRR 13 | ||||
Sequence: RLIYLSVARNKLESIPDEISDL | ||||||
Repeat | 928-950 | LRR 14 | ||||
Sequence: SLKSLDLHSNNLRMLMNNLEDLE | ||||||
Repeat | 951-971 | LRR 15 | ||||
Sequence: LTSLNVSSNLLTGFHGSPAKF | ||||||
Repeat | 982-1004 | LRR 16 | ||||
Sequence: SLLFLSVADNNLTDSIWPLVNTF | ||||||
Repeat | 1006-1027 | LRR 17 | ||||
Sequence: NLKTLNLSYNNFVEISDLKLQN | ||||||
Repeat | 1028-1048 | LRR 18 | ||||
Sequence: LTELYLSGNNFTSLPGEAVQH | ||||||
Repeat | 1051-1073 | LRR 19 | ||||
Sequence: SLKVLMLNGNKLLSLPAELSQLS | ||||||
Repeat | 1074-1096 | LRR 20 | ||||
Sequence: RLSVLDVGSNQLKYNISNYHYDW | ||||||
Repeat | 1103-1124 | LRR 21 | ||||
Sequence: DLKYLNFSGNKRFEIKSALDPE | ||||||
Repeat | 1135-1160 | LRR 22 | ||||
Sequence: LKQLRVLGLMDVTLKTSKVPDESVSI | ||||||
Domain | 1173-1439 | PPM-type phosphatase | ||||
Sequence: RYGVADTLGQSDSVCSRDVTFERFRGREDECLICLYDGKNENASSGHKISKIIRDIYDKILIRLLEKYGEESDGIKRALRYSFLQLNKEINGMLVSVEDGNTDSGLTSADLLSGSSATVVYLKGKKIYTANIGDTMAVLSKNNGDFVTLTKLHVPAEREEYERIRTSGGYVNNQKLDGVSEVSRAVGFFDLLPHIHASPDISETVLSYSDEMLIIATHKLWEYLDYETVCDISRENKSQPMSAAEKMKDYAISYGCSDNITILCVSL | ||||||
Domain | 1483-1620 | Guanylate cyclase | ||||
Sequence: AIVFTDIKNSTFLWELFPDAMRAAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSALVWCLSVQLKLLEAEWPEEITSIQDGCLITDNSGTKVYLGLSVRMGVHWGCPVPEIDLVTQRMDYLGPVVNKAARVS |
Sequence similarities
Belongs to the adenylyl cyclase class-3 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,839
- Mass (Da)206,896
- Last updated1991-11-01 v1
- Checksum86A69BCB1F2733CB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 43-63 | Basic and acidic residues | ||||
Sequence: ITTHTNDEDDDPRDHRQRGIH | ||||||
Compositional bias | 126-147 | Polar residues | ||||
Sequence: TSLLGTEHQQRQQQQSSNSLVP | ||||||
Compositional bias | 159-221 | Polar residues | ||||
Sequence: IHGGSGSQSNESRGTRSSIFFPSTSNSRRGSATSTMTSGSRSSHPPDTPPITSQQQEQQYDQQ | ||||||
Compositional bias | 294-311 | Polar residues | ||||
Sequence: PLSSHKSTSASDLSHHKA | ||||||
Compositional bias | 332-355 | Basic residues | ||||
Sequence: KRKAKHHHHYHHPQHPRPPHRKHY | ||||||
Compositional bias | 356-376 | Basic and acidic residues | ||||
Sequence: SNFSKPIEDKAVVEKEQEPPE | ||||||
Compositional bias | 402-449 | Polar residues | ||||
Sequence: SGIQHSASTQSVSSFSSGATGASGATGKQIGGDQETESTISTVGEDEE | ||||||
Compositional bias | 450-468 | Basic and acidic residues | ||||
Sequence: VTNLRSIDSEQTDDTSFSK |