P23299 · KCNE1_MOUSE
- ProteinPotassium voltage-gated channel subfamily E member 1
- GeneKcne1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids129 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P23299
Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 96673
High-resolution recombinational map of mouse chromosome 16.
- CategorySequences
- SourceMGI: 96673
Inner ear defects induced by null mutation of the isk gene.
- CategoriesFunction, Sequences
- SourceMGI: 96673
Differential expression of Isk mRNAs in mouse tissue during development and pregnancy.
- CategorySequences
- SourceMGI: 96673
Genetic determinants of micronucleus formation in vivo.
- CategoryFunction
- SourceMGI: 96673
KCNE1 does not shift TMEM16A from a Ca<sup>2+</sup> dependent to a voltage dependent Cl<sup>-</sup> channel and is not expressed in renal proximal tubule.
- AnnotationKCNE1 does not shift TMEM16A from a Ca[2+]
- CategoryStructure
- SourceGeneRif: 16509
TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine.
- CategoriesNames, Sequences
- SourceMGI: 96673
<i>LAMP2</i> Cardiomyopathy: Consequences of Impaired Autophagy in the Heart.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 96673
Elevation of propofol sensitivity of cardiac I<sub>Ks</sub> channel by KCNE1 polymorphism D85N.
- AnnotationElevation of propofol sensitivity of cardiac IKs channel by KCNE1 polymorphism D85N.
- SourceGeneRif: 16509
Gene therapy via canalostomy approach preserves auditory and vestibular functions in a mouse model of Jervell and Lange-Nielsen syndrome type 2.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 96673
KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies.
- AnnotationKCNE1 is an auxiliary subunit of two distinct ion channel superfamilies.
- CategoryFunction
Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 96673
SUMOylation determines the voltage required to activate cardiac <i>I</i><sub><i>Ks</i></sub> channels.
- AnnotationSUMOylation of KCNQ1 is KCNE1 dependent and determines the native attributes of cardiac IKs in vivo.
- CategoryPTM / Processing
- SourceGeneRif: 16509
Remodeling of repolarization and arrhythmia susceptibility in a myosin- binding protein C knockout mouse model.
- CategoryPhenotypes & Variants
- SourceMGI: 96673
BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).
- AnnotationThe electrophysiological effects of BACE1 on KCNQ1 reported here were independent of its enzymatic activity.
- CategoryInteraction
KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation.
- AnnotationKCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation
- CategoriesFunction, Interaction
- SourceGeneRif: 16509
Mapped toMyoR modulates cardiac conduction by repressing Gata4.
- CategoriesFunction, Interaction
- SourceMGI: 96673
BACE1 and presenilin/gamma-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
- AnnotationKCNE1 and KCNE2 auxiliary subunits of voltage-gated potassium channels undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells.
- CategoryPTM / Processing
Critical roles of transitional cells and Na/K-ATPase in the formation of vestibular endolymph.
- AnnotationThis study confirmed that KCNE1 channels are necessary for K+ secretion in developmental Saccule and Utricle in mice.
- CategoryFunction
- SourceGeneRif: 16509
O-glycosylation of the cardiac I(Ks) complex.
- CategoriesPTM / Processing, Phenotypes & Variants
- SourceMGI: 96673