P23299 · KCNE1_MOUSE

  • Protein
    Potassium voltage-gated channel subfamily E member 1
  • Gene
    Kcne1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell surface
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentvoltage-gated potassium channel complex
Cellular ComponentZ disc
Molecular Functiondelayed rectifier potassium channel activity
Molecular Functionpotassium channel regulator activity
Molecular Functionprotein-containing complex binding
Molecular Functiontelethonin binding
Molecular Functiontransmembrane transporter binding
Biological Processcardiac muscle cell contraction
Biological Processcellular response to acidic pH
Biological Processcellular response to cAMP
Biological Processcellular response to light stimulus
Biological Processepithelial cell maturation
Biological Processheart contraction
Biological Processmale gonad development
Biological Processmembrane repolarization during action potential
Biological Processmembrane repolarization during cardiac muscle cell action potential
Biological Processmembrane repolarization during ventricular cardiac muscle cell action potential
Biological Processnegative regulation of delayed rectifier potassium channel activity
Biological Processnegative regulation of protein targeting to membrane
Biological Processpositive regulation of potassium ion transmembrane transport
Biological Processpotassium ion export across plasma membrane
Biological Processpotassium ion transmembrane transport
Biological Processregulation of heart rate by cardiac conduction
Biological Processregulation of ventricular cardiac muscle cell membrane repolarization
Biological Processsecretory granule organization
Biological Processventricular cardiac muscle cell action potential
Biological Processvestibular nucleus development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Potassium voltage-gated channel subfamily E member 1
  • Alternative names
    • Delayed rectifier potassium channel subunit IsK (mISK
      )
    • IKs producing slow voltage-gated potassium channel subunit beta Mink
    • Minimal potassium channel (MinK
      )

Gene names

    • Name
      Kcne1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P23299

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Apical cell membrane
Membrane raft
Note: Colocalizes with KCNB1 at the plasma membrane (By similarity).
Targets to the membrane raft when associated with KCNQ1 (By similarity).

Features

Showing features for transmembrane, topological domain.

TypeIDPosition(s)Description
Transmembrane44-66Helical
Topological domain67-129Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001442791-129Potassium voltage-gated channel subfamily E member 1
Glycosylation5N-linked (GlcNAc...) asparagine
Glycosylation7O-linked (GalNAc...) threonine
Glycosylation26N-linked (GlcNAc...) asparagine
Modified residue102Phosphoserine; by PKC

Post-translational modification

Phosphorylation inhibits the potassium current.
N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Restrictively localized in the apical membrane portion of epithelial cells.

Gene expression databases

Interaction

Subunit

Interacts with KCNB1. Interacts with KCNC2 (By similarity).
Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity) (PubMed:8900282).
View interactors in UniProtKB
View CPX-3198 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the potassium channel KCNE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    129
  • Mass (Da)
    14,578
  • Last updated
    1991-11-01 v1
  • Checksum
    E66DF4742300E839
MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X60457
EMBL· GenBank· DDBJ
CAA42990.1
EMBL· GenBank· DDBJ
mRNA
AK028907
EMBL· GenBank· DDBJ
BAC26189.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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