P23092 · CBL_MLVCN
- ProteinTransforming protein cbl
- GeneV-CBL
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids390 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Induces early B-lineage lymphomas.
Miscellaneous
This protein is synthesized as a Gag-Cbl polyprotein.
This protein has one functional calcium-binding site.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 259 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 261 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 263 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 265 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 270 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 324 | 4-O-phospho-L-tyrosine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane raft | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | phosphotyrosine residue binding | |
Molecular Function | receptor tyrosine kinase binding | |
Molecular Function | SH3 domain binding | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | negative regulation of epidermal growth factor-activated receptor activity |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTransforming protein cbl
Gene names
Organism names
- Organism
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Gammaretrovirus > Murine leukemia virus
- Virus hosts
Accessions
- Primary accessionP23092
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Keywords
- Disease
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000055868 | 1-390 | Transforming protein cbl | ||
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-52 | Disordered | |||
Region | 77-205 | 4H | |||
Domain | 77-381 | Cbl-PTB | |||
Region | 206-278 | EF-hand-like | |||
Region | 279-381 | SH2-like | |||
Domain
Is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain (By similarity).
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length390
- Mass (Da)43,692
- Last updated1991-11-01 v1
- ChecksumEB72483746827AB0
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J04169 EMBL· GenBank· DDBJ | AAA42885.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |