P23092 · CBL_MLVCN

Function

function

Induces early B-lineage lymphomas.

Miscellaneous

This protein is synthesized as a Gag-Cbl polyprotein.
This protein has one functional calcium-binding site.

Features

Showing features for binding site.

139050100150200250300350
TypeIDPosition(s)Description
Binding site259Ca2+ (UniProtKB | ChEBI)
Binding site261Ca2+ (UniProtKB | ChEBI)
Binding site263Ca2+ (UniProtKB | ChEBI)
Binding site265Ca2+ (UniProtKB | ChEBI)
Binding site270Ca2+ (UniProtKB | ChEBI)
Binding site3244-O-phospho-L-tyrosine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionphosphotyrosine residue binding
Molecular Functionreceptor tyrosine kinase binding
Molecular FunctionSH3 domain binding
Molecular Functionubiquitin protein ligase activity
Biological Processcell surface receptor signaling pathway
Biological Processnegative regulation of epidermal growth factor-activated receptor activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transforming protein cbl

Gene names

    • Name
      V-CBL

Organism names

Accessions

  • Primary accession
    P23092

Subcellular Location

Phenotypes & Variants

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000558681-390Transforming protein cbl

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-52Disordered
Region77-2054H
Domain77-381Cbl-PTB
Region206-278EF-hand-like
Region279-381SH2-like

Domain

Is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain (By similarity).

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    43,692
  • Last updated
    1991-11-01 v1
  • Checksum
    EB72483746827AB0
ASAGGGCRRGPSFSPGSIPSLAAERAPDPPLAMAGNVKKSSGAGGGGSGGSGAGGLIGLMKDAFQPHHHHHHLSPHPPCTVDKKMVEKCWKLMDKVVRLCQNPNVALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPHFS

Sequence caution

The sequence AAA42885.1 differs from that shown. Reason: Erroneous initiation

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J04169
EMBL· GenBank· DDBJ
AAA42885.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Similar Proteins

Disclaimer

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