Human gammaS-Crystallin Mutation F10_Y11delinsLN in the First Greek Key Pair Destabilizes and Impairs Tight Packing Causing Cortical Lamellar Cataract.
The cataract-related S39C variant increases gammaS-crystallin sensitivity to environmental stress by destroying the intermolecular disulfide cross-links.
Human alphaB-crystallin distinguishes between highly similar variants of a structural crystallin binding the cataract-related gammaS-G18V variant but not the function-preserving gammaS-G18A variant which is monomeric at physiological temperature.
Zn2+-driven aggregation of gamma S crystallin proceeds through cysteine coordination whereas Cu2+-driven aggregation results from methionine oxidation.
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