The findings show that at least in the cases of Mn Pb Cd and Hg metal "inhibition" of ferrochelatase occurs after metal insertion and results from poor or diminished product release.
It was found that in the H263C and H341C variants but not the F337A variant enzymes the side chains of N75 M76 R164 H263 F337 H341 and E343 are oriented in a fashion similar to what is found in ferrochelatase with the bound porphyrin substrate
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