P22687 · CETP_RABIT

Function

function

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641).
Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componenthigh-density lipoprotein particle
Molecular Functioncholesterol binding
Molecular Functioncholesterol transfer activity
Molecular Functionphosphatidylcholine binding
Molecular Functionphospholipid transporter activity
Molecular Functiontriglyceride binding
Biological Processcholesterol homeostasis
Biological Processcholesterol metabolic process
Biological Processcholesterol transport
Biological Processhigh-density lipoprotein particle remodeling
Biological Processlow-density lipoprotein particle remodeling
Biological Processphosphatidylcholine metabolic process
Biological Processphospholipid homeostasis
Biological Processreverse cholesterol transport
Biological Processtriglyceride homeostasis
Biological Processtriglyceride metabolic process
Biological Processtriglyceride transport
Biological Processvery-low-density lipoprotein particle remodeling

Keywords

Protein family/group databases

    • 1.C.40.1.3the bactericidal permeability increasing protein (bpip) family

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Cholesteryl ester transfer protein
  • Alternative names
    • Lipid transfer protein I

Gene names

    • Name
      CETP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    P22687

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1
ChainPRO_00000171572-497Cholesteryl ester transfer protein
Glycosylation89N-linked (GlcNAc...) asparagine
Glycosylation99N-linked (GlcNAc...) asparagine
Glycosylation111N-linked (GlcNAc...) asparagine
Disulfide bond144↔185
Glycosylation241N-linked (GlcNAc...) asparagine
Glycosylation403N-linked (GlcNAc...) asparagine
Glycosylation417N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed by the liver.

Interaction

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    497
  • Mass (Da)
    54,514
  • Last updated
    1991-08-01 v1
  • Checksum
    E82944E1821D0332
ACPKGASYEAGIVCRITKPALLVLNQETAKVVQTAFQRAGYPDVSGERAVMLLGRVKYGLHNLQISHLSIASSQVELVDAKTIDVAIQNVSVVFKGTLNYSYTSAWGLGINQSVDFEIDSAIDLQINTELTCDAGSVRTNAPDCYLAFHKLLLHLQGEREPGWLKQLFTNFISFTLKLILKRQVCNEINTISNIMADFVQTRAASILSDGDIGVDISVTGAPVITATYLESHHKGHFTHKNVSEAFPLRAFPPGLLGDSRMLYFWFSDQVLNSLARAAFQEGRLVLSLTGDEFKKVLETQGFDTNQEIFQELSRGLPTGQAQVAVHCLKVPKISCQNRGVVVSSSVAVTFRFPRPDGREAVAYRFEEDIITTVQASYSQKKLFLHLLDFQCVPASGRAGSSANLSVALRTEAKAVSNLTESRSESLQSSLRSLIATVGIPEVMSRLEVAFTALMNSKGLDLFEIINPEIITLDGCLLLQMDFGFPKHLLVDFLQSLS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M27486
EMBL· GenBank· DDBJ
AAA31199.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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