P22649 · KITH_BHV2H

Function

function

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.

Catalytic activity

Features

Showing features for binding site, active site.

132350100150200250300
Type
IDPosition(s)Description
Binding site11-18ATP (UniProtKB | ChEBI)
Active site36Proton acceptor
Binding site54substrate
Binding site78substrate
Binding site169ATP (UniProtKB | ChEBI)
Binding site175substrate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionthymidine kinase activity
Biological ProcessDNA biosynthetic process
Biological Processphosphorylation
Biological ProcessTMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thymidine kinase
  • EC number

Gene names

    • Name
      TK

Organism names

Accessions

  • Primary accession
    P22649

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001750631-323Thymidine kinase

Expression

Keywords

Interaction

Subunit

Homodimer.

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    323
  • Mass (Da)
    34,661
  • Last updated
    2002-05-27 v2
  • MD5 Checksum
    5E078CE557A5F7022EA93D439DBEE0FE
MSRLLRVYVDGPHGLGKTTAASALASERGDAIYLPEPMSYWSGAGEDDLVARVYTAQHRMDRGEIDAREAAGVVLGAQLTMSTPYVALNGLIAPHIGEEPSPGNATPPDLILIFDRHPIASLLCYPLARYLTRCLPIESVLSLIALIPPTPPGTNLILGTAPAEDHLSRLVARGRPGELPDARMLRAIRYVYALLANTVKYLQSGGSWRADLGSEPPRLPLAPPEIGDPNNPGGHNTLLALIHGAGATRGCAAMTSWTLDLLADRLRSMNMFTVDYSAPPEACVAQMRNLLPSMQCTVTPKPESHRAVADAALAFMREMSNCK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D00537
EMBL· GenBank· DDBJ
BAA00425.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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