P22455 · FGFR4_HUMAN
- ProteinFibroblast growth factor receptor 4
- GeneFGFR4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids802 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Activity regulation
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 473-481 | ATP (UniProtKB | ChEBI) | |||
Binding site | 503 | ATP (UniProtKB | ChEBI) | |||
Active site | 612 | Proton acceptor | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Community annotation
FGFR4 p.G388R variant increases phosphorylation of STAT3 (at Tyr-705) and thereby enhances STAT3 signaling in CD4(+)CD25(+)FOXP3(+) regulatory T cells in rs351855-A allele SNP knock-in mice; thereby suppresses the expansion of CD8 T cells in the lymph nodes and tumor milieu.
Source | Submission date | Contributor |
---|---|---|
PubMed:29438108 | 0000-0002-4717-6228 |
Names & Taxonomy
Protein names
- Recommended nameFibroblast growth factor receptor 4
- EC number
- Short namesFGFR-4
- CD Antigen Name
Gene names
Community suggested name: Fibroblast growth factor receptor 4; FGFR4; CD334.
Source | Submission date | Contributor |
---|---|---|
PubMed:29438108 | 0000-0002-4717-6228 |
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP22455
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Isoform 2
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 22-369 | Extracellular | |||
Transmembrane | 370-390 | Helical | |||
Topological domain | 391-802 | Cytoplasmic | |||
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | VAR_029185 | 10 | in dbSNP:rs1966265 | ||
Natural variant | VAR_042211 | 136 | in dbSNP:rs376618 | ||
Natural variant | VAR_042212 | 179 | in dbSNP:rs55675160 | ||
Natural variant | VAR_014797 | 388 | in cancer cells, may be associated with accelerated disease progression and increased tumor cell motility, possibly due to increased stability of the protease MMP14; leads to phosphorylation at residue Y-390, resulting in prolonged FGFR4 activity; increases interaction with STAT3, resulting in STAT3 phosphorylation and signaling activation.; dbSNP:rs351855 | ||
Natural variant | VAR_046102 | 426 | in dbSNP:rs55879131 | ||
Mutagenesis | 503 | Loss of kinase activity. | |||
Natural variant | VAR_042213 | 516 | in dbSNP:rs34158682 | ||
Natural variant | VAR_049720 | 529 | in dbSNP:rs34284947 | ||
Natural variant | VAR_046103 | 550 | in breast pleomorphic lobular sample; somatic mutation; dbSNP:rs774571806 | ||
Natural variant | VAR_046104 | 712 | in a lung adenocarcinoma sample; somatic mutation | ||
Mutagenesis | 754 | Loss of interaction with PLCG1. | |||
Natural variant | VAR_046105 | 772 | in a lung neuroendocrine carcinoma sample; somatic mutation | ||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,816 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Signal | 1-21 | UniProt | ||||
Chain | PRO_0000016787 | 22-802 | UniProt | Fibroblast growth factor receptor 4 | ||
Disulfide bond | 57↔101 | UniProt | ||||
Glycosylation | 112 | UniProt | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 172↔224 | UniProt | ||||
Glycosylation | 258 | UniProt | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 271↔333 | UniProt | ||||
Glycosylation | 290 | UniProt | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 311 | UniProt | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 322 | UniProt | N-linked (GlcNAc...) asparagine | |||
Modified residue | 390 | UniProt | Phosphotyrosine; in variant R-388 | |||
Modified residue (large scale data) | 419 | PRIDE | Phosphoserine | |||
Modified residue | 573 | UniProt | Phosphoserine | |||
Modified residue (large scale data) | 573 | PRIDE | Phosphoserine | |||
Modified residue | 642 | UniProt | Phosphotyrosine; by autocatalysis | |||
Modified residue (large scale data) | 642 | PRIDE | Phosphotyrosine | |||
Modified residue | 643 | UniProt | Phosphotyrosine; by autocatalysis | |||
Modified residue | 754 | UniProt | Phosphotyrosine; by autocatalysis | |||
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with STAT3 (PubMed:26675719).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P22455 | FGFR1 P11362 | 3 | EBI-6256193, EBI-1028277 | |
BINARY | P22455 | MMP14 P50281 | 6 | EBI-6256193, EBI-992788 | |
BINARY | P22455 | RET P07949 | 2 | EBI-6256193, EBI-2480756 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 22-118 | Ig-like C2-type 1 | |||
Region | 119-148 | Disordered | |||
Compositional bias | 124-138 | Basic and acidic residues | |||
Domain | 152-240 | Ig-like C2-type 2 | |||
Domain | 249-349 | Ig-like C2-type 3 | |||
Domain | 467-755 | Protein kinase | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P22455-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length802
- Mass (Da)87,954
- Last updated2001-04-27 v2
- MD5 Checksum0C799CD8EB4A963B013291894BF69E69
P22455-2
- Name2
- SynonymsSoluble-form
- Differences from canonical
- 353-416: EEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLAR → GTGRIPHLTCDSLTPAGRTKSPTL
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, compositional bias, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 121 | in Ref. 3; AAF27432 | |||
Compositional bias | 124-138 | Basic and acidic residues | |||
Sequence conflict | 194 | in Ref. 3; AAF27432 | |||
Sequence conflict | 297 | in Ref. 1; CAA40490 | |||
Alternative sequence | VSP_035108 | 353-416 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X57205 EMBL· GenBank· DDBJ | CAA40490.1 EMBL· GenBank· DDBJ | mRNA | ||
L03840 EMBL· GenBank· DDBJ | AAB59389.1 EMBL· GenBank· DDBJ | mRNA | ||
AF202063 EMBL· GenBank· DDBJ | AAF27432.1 EMBL· GenBank· DDBJ | mRNA | ||
Y13901 EMBL· GenBank· DDBJ | CAA74200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF359246 EMBL· GenBank· DDBJ | AAK51435.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007471 EMBL· GenBank· DDBJ | AEO19712.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007472 EMBL· GenBank· DDBJ | AEO19713.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007473 EMBL· GenBank· DDBJ | AEO19714.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007474 EMBL· GenBank· DDBJ | AEO19715.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007475 EMBL· GenBank· DDBJ | AEO19716.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007476 EMBL· GenBank· DDBJ | AEO19717.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007477 EMBL· GenBank· DDBJ | AEO19718.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007478 EMBL· GenBank· DDBJ | AEO19719.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007479 EMBL· GenBank· DDBJ | AEO19720.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007480 EMBL· GenBank· DDBJ | AEO19721.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007481 EMBL· GenBank· DDBJ | AEO19722.1 EMBL· GenBank· DDBJ | mRNA | ||
JN007482 EMBL· GenBank· DDBJ | AEO19723.1 EMBL· GenBank· DDBJ | mRNA | ||
AF487555 EMBL· GenBank· DDBJ | AAM13666.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF571596 EMBL· GenBank· DDBJ | ABQ01235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC027314 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471195 EMBL· GenBank· DDBJ | EAW85036.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC011847 EMBL· GenBank· DDBJ | AAH11847.1 EMBL· GenBank· DDBJ | mRNA | ||
M59373 EMBL· GenBank· DDBJ | AAA63208.1 EMBL· GenBank· DDBJ | mRNA |