P22398 · PSPC_RABIT

Function

function

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentalveolar lamellar body
Cellular Componentextracellular space
Biological Processrespiratory gaseous exchange by respiratory system

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Surfactant protein C
  • Short names
    SP-C
  • Alternative names
    • Pulmonary surfactant-associated protein C
    • Pulmonary surfactant-associated proteolipid SPL(Val)

Gene names

    • Name
      SFTPC
    • Synonyms
      SFTP2

Organism names

  • Taxonomic identifier
  • Strain
    • New Zealand white
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    P22398

Proteomes

PTM/Processing

Features

Showing features for propeptide, chain, lipidation, disulfide bond.

TypeIDPosition(s)Description
PropeptidePRO_00000334891-23
ChainPRO_000003349024-58Surfactant protein C
Lipidation28S-palmitoyl cysteine
Lipidation29S-palmitoyl cysteine
PropeptidePRO_000003349159-188
Disulfide bond121↔180

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain94-188BRICHOS
Region144-164Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    188
  • Mass (Da)
    19,836
  • Last updated
    1996-10-01 v3
  • Checksum
    F622EEA933786F78
MDMGSKEALMESPPDYSAAPRGRFGIPCCPVHLKRLLIVVVVVVLVVVVIVGALLMGLHMSQKHTEMVLEMSIGAPEVQQRLALSEWAGTTATFPIGSTGIVTCDYQRLLIAYKPAPGTCCYLMKMAPDSIPSLEALARKFQANPAEPPTQRGQDKGPAAGPASSGGELAFLGAAVSTLCGEVPLIYI

Sequence caution

The sequence CAA46204.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict115in Ref. 2; AAB24761/AAB24762
Sequence conflict153in Ref. 4; AAB24576
Sequence conflict159in Ref. 4; AAB24576
Sequence conflict161in Ref. 1; CAA46204
Sequence conflict186in Ref. 4; AAB24576

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X65078
EMBL· GenBank· DDBJ
CAA46204.1
EMBL· GenBank· DDBJ
mRNA Different initiation
S51983
EMBL· GenBank· DDBJ
AAB24761.1
EMBL· GenBank· DDBJ
mRNA
AF037445
EMBL· GenBank· DDBJ
AAC18032.1
EMBL· GenBank· DDBJ
Genomic DNA
S51597
EMBL· GenBank· DDBJ
AAB24762.1
EMBL· GenBank· DDBJ
mRNA
S51098
EMBL· GenBank· DDBJ
AAB24576.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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