P22360 · KPYK_EMENI

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
K+ (UniProtKB | Rhea| CHEBI:29103 )

Activity regulation

Regulated by phosphoenolpyruvate substrate and allosteric effectors such as fructose 1,6 diphosphate and magnesium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site63substrate
Binding site65K+ (UniProtKB | ChEBI)
Binding site65-68ATP (UniProtKB | ChEBI)
Binding site67K+ (UniProtKB | ChEBI)
Binding site98K+ (UniProtKB | ChEBI)
Binding site99K+ (UniProtKB | ChEBI)
Binding site105ATP (UniProtKB | ChEBI)
Binding site191ATP (UniProtKB | ChEBI)
Site254Transition state stabilizer
Binding site256Mg2+ (UniProtKB | ChEBI)
Binding site279substrate
Binding site280Mg2+ (UniProtKB | ChEBI)
Binding site280substrate
Binding site312substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionpotassium ion binding
Molecular Functionpyruvate kinase activity
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      pkiA
    • Synonyms
      pki
    • ORF names
      AN5210

Organism names

Accessions

  • Primary accession
    P22360
  • Secondary accessions
    • C8VF86
    • Q5B2M0

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001121131-526Pyruvate kinase
Modified residue36Phosphoserine

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the pyruvate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    526
  • Mass (Da)
    58,133
  • Last updated
    2007-05-01 v2
  • Checksum
    BCD3A6F35F5D28B2
MAASSSLDHLSNRMKLEWHSKLNTEMVPAKNFRRTSIICTIGPKTNSVEKINALRRAGLNVVRMNFSHGSYEYHQSVIDHAREAEKQQAGRPVAIALDTKGPEIRTGNTVGDKDIPIKAGHEMNISTDEQYATASDDQNMYVDYKNITKVISAGKLIYVDDGILSFEVLEVVDDKTLRVRCLNNGNISSRKGVNLPGTDVDLPALSEKDISDLKFGVKNKVDMVFASFIRRGSDIRHIREVLGEEGREIQIIAKIENQQGVNNFDEILEETDGVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDVANAVLDGADCVMLSGETAKGNYPCEAVTMMSETCLLAEVAIPHFNVFDELRNLAPRPTDTVESIAMAAVSASLELNAGAIVVLTTSGNTARMISKYRPVCPIIMVSRNPAATRYSHLYRGVWPFYFPEKKPDFNVKIWQEDVDRRLKWGINHGLKLGIINKGDNIVCVQGWRGGMGHTNTVRVVPAEENLGLSE

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict88in Ref. 1; AAA33320

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M36918
EMBL· GenBank· DDBJ
AAA33320.1
EMBL· GenBank· DDBJ
Genomic DNA
AACD01000089
EMBL· GenBank· DDBJ
EAA62391.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001305
EMBL· GenBank· DDBJ
CBF81089.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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