P22292 · M2OM_BOVIN
- ProteinMitochondrial 2-oxoglutarate/malate carrier protein
- GeneSLC25A11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids314 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed:27479487, PubMed:3814587, PubMed:8363582).
Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (PubMed:8363582).
Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (PubMed:14598172).
Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity).
Involved in the regulation of apoptosis (By similarity).
Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).
Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (PubMed:8363582).
Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (PubMed:14598172).
Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity).
Involved in the regulation of apoptosis (By similarity).
Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).
Catalytic activity
- (S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)(S)-malate (in)CHEBI:15589
+ 2-oxoglutarate (out)CHEBI:16810= (S)-malate (out)CHEBI:15589+ 2-oxoglutarate (in)CHEBI:16810 - 2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) + malonate(out)
- 2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) + succinate(out)
- 2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) + maleate(out)
- 2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) + oxaloacetate(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Molecular Function | antiporter activity | |
Molecular Function | malate transmembrane transporter activity | |
Molecular Function | oxaloacetate transmembrane transporter activity | |
Molecular Function | oxoglutarate:malate antiporter activity | |
Molecular Function | succinate transmembrane transporter activity | |
Molecular Function | sulfate transmembrane transporter activity | |
Molecular Function | thiosulfate transmembrane transporter activity | |
Biological Process | gluconeogenesis | |
Biological Process | lipid transport | |
Biological Process | malate transmembrane transport | |
Biological Process | oxaloacetate transport | |
Biological Process | phosphate ion transmembrane transport | |
Biological Process | succinate transmembrane transport | |
Biological Process | sulfate transport | |
Biological Process | thiosulfate transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMitochondrial 2-oxoglutarate/malate carrier protein
- Short namesOGCP; alpha-oxoglutarate carrier
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionP22292
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 24-42 | Helical; Name=1 | ||||
Sequence: KFLFGGLAGMGATVFVQPL | ||||||
Transmembrane | 83-101 | Helical; Name=2 | ||||
Sequence: GLSAGLLRQATYTTTRLGI | ||||||
Transmembrane | 119-140 | Helical; Name=3 | ||||
Sequence: FLLKAVIGMTAGATGAFVGTPA | ||||||
Transmembrane | 183-202 | Helical; Name=4 | ||||
Sequence: GCIPTMARAVVVNAAQLASY | ||||||
Transmembrane | 222-240 | Helical; Name=5 | ||||
Sequence: HFCASMISGLVTTAASMPV | ||||||
Transmembrane | 281-300 | Helical; Name=6 | ||||
Sequence: GFTPYYARLGPHTVLTFIFL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000090624 | 2-314 | Mitochondrial 2-oxoglutarate/malate carrier protein | |||
Sequence: AATASPGASGMDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALISILRAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPVDQRRGYKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLVKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG | ||||||
Modified residue | 6 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 57 | N6-succinyllysine | ||||
Sequence: K | ||||||
Modified residue | 102 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 256 | N6-acetyllysine | ||||
Sequence: K |
Post-translational modification
The N-terminus is blocked.
Keywords
- PTM
Proteomic databases
Expression
Interaction
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 23-108 | Solcar 1 | ||||
Sequence: VKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALISILRAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFER | ||||||
Repeat | 117-208 | Solcar 2 | ||||
Sequence: PGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPVDQRRGYKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQF | ||||||
Repeat | 217-306 | Solcar 3 | ||||
Sequence: DNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLVKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKA |
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length314
- Mass (Da)34,172
- Last updated2007-01-23 v3
- Checksum1FF22D1A0B3D36E9
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAF6ZBW5 | A0AAF6ZBW5_BOVIN | SLC25A11 | 263 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X66115 EMBL· GenBank· DDBJ | CAA46906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M58703 EMBL· GenBank· DDBJ | AAA30671.1 EMBL· GenBank· DDBJ | mRNA | ||
M60662 EMBL· GenBank· DDBJ | AAA30672.1 EMBL· GenBank· DDBJ | mRNA | ||
BT020806 EMBL· GenBank· DDBJ | AAX08823.1 EMBL· GenBank· DDBJ | mRNA | ||
BC142283 EMBL· GenBank· DDBJ | AAI42284.1 EMBL· GenBank· DDBJ | mRNA | ||
BC146129 EMBL· GenBank· DDBJ | AAI46130.1 EMBL· GenBank· DDBJ | mRNA |