P22008 · P5CR_PSEAE
- ProteinPyrroline-5-carboxylate reductase
- GeneproC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids273 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Catalytic activity
- L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + 2 H+
Pathway
Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | pyrroline-5-carboxylate reductase activity | |
Biological Process | L-proline biosynthetic process | |
Biological Process | proline biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyrroline-5-carboxylate reductase
- EC number
- Short namesP5C reductase ; P5CR
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionP22008
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000187296 | 2-273 | Pyrroline-5-carboxylate reductase | |||
Sequence: STPRIAFIGAGNMAASLIGGLRAQGVPAAQIRASDPGAEQRAKIAGEFAIDVVESNAEAVADADVVVLSVKPQAMKAVCQALAPALKPEQLIVSIAAGIPCASLEAWLGQPRPVVRCMPNTPALLRQGASGLYANAQVSAAQCEQAGQLLSAVGIALWLDDEAQIDAVTAVSGSGPAYFFLLMQAMTDAGEKLGLSRETASRLTLQTALGAAQMALSSEVEPAELRRRVTSPNGTTEAAIKSFQANGFEALVEQALNAASQRSAELAEQLGQ |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)28,094
- Last updated2007-01-23 v2
- Checksum6B2D191635E8DEE0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M33557 EMBL· GenBank· DDBJ | AAA25975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE004091 EMBL· GenBank· DDBJ | AAG03782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M55524 EMBL· GenBank· DDBJ | AAA25958.1 EMBL· GenBank· DDBJ | Genomic DNA |