P21999 · NFIC_PIG

  • Protein
    Nuclear factor 1 C-type
  • Gene
    NFIC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Features

Showing features for dna binding.

150650100150200250300350400450500
TypeIDPosition(s)Description
DNA binding1-195CTF/NF-I

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological ProcessDNA replication
Biological Processpositive regulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear factor 1 C-type
  • Short names
    NF1-C; Nuclear factor 1/C
  • Alternative names
    • CCAAT-box-binding transcription factor (CTF)
    • Nuclear factor I/C (NF-I/C; NFI-C)
    • TGGCA-binding protein

Gene names

    • Name
      NFIC
    • Synonyms
      NFI

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    P21999

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00001002011-506Nuclear factor 1 C-type
Modified residue194Phosphoserine
Modified residue294Phosphoserine
Modified residue300Phosphotyrosine
Modified residue302Phosphoserine
Modified residue304Phosphoserine
Modified residue305Phosphoserine
Modified residue323Phosphoserine
Modified residue333Phosphoserine
Modified residue337Phosphoserine
Modified residue339Phosphoserine
Modified residue343Phosphoserine
Modified residue365Asymmetric dimethylarginine; alternate
Modified residue365Omega-N-methylarginine; alternate
Modified residue395Asymmetric dimethylarginine
Modified residue451Omega-N-methylarginine
Modified residue473Phosphoserine
Modified residue475Phosphoserine
Modified residue485Phosphoserine

Keywords

Interaction

Subunit

Binds DNA as a homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region261-348Disordered
Compositional bias266-281Polar residues
Compositional bias297-317Polar residues
Compositional bias329-348Polar residues
Motif404-4129aaTAD
Region439-493Disordered
Compositional bias460-483Polar residues

Domain

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

Sequence similarities

Belongs to the CTF/NF-I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced.

P21999-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    506
  • Mass (Da)
    55,462
  • Last updated
    1991-08-01 v1
  • Checksum
    6315A9474807F4C0
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRAGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHMAYDLNPASTGMRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSNRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMSSHCLSAQMLAPPPPGLPRLALPPATKPTSEGGSSSPTSPSYSTPGTSPANRSFVGLGPRDPTGIYQAQSWYLG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias266-281Polar residues
Compositional bias297-317Polar residues
Compositional bias329-348Polar residues
Compositional bias460-483Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J02875
EMBL· GenBank· DDBJ
AAA31093.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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