P21965 · MCK1_YEAST

Function

function

May be an autophosphorylating tyrosine kinase, a bifunctional (serine/tyrosine-specific) protein kinase, or a serine kinase that is a substrate for an associated tyrosine kinase. MCK1 is a transcriptional activator of IME1, it stimulates spore maturation, and play a positive regulatory role in both mitotic centromere function and activation of early meiotic gene expression.

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site41-49ATP (UniProtKB | ChEBI)
Binding site68ATP (UniProtKB | ChEBI)
Active site164Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functioncyclin binding
Molecular Functionenzyme inhibitor activity
Molecular Functionprotein kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionprotein serine/threonine/tyrosine kinase activity
Molecular Functionprotein tyrosine kinase activity
Biological Processascospore formation
Biological Processcell differentiation
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processmeiotic cell cycle
Biological Processmitotic sister chromatid segregation
Biological Processmitotic spindle orientation checkpoint signaling
Biological Processprotein catabolic process
Biological Processprotein phosphorylation
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein kinase MCK1
  • EC number
  • Alternative names
    • Meiosis and centromere regulatory kinase

Gene names

    • Name
      MCK1
    • Synonyms
      YPK1
    • ORF names
      N0392
    • Ordered locus names
      YNL307C

Organism names

Accessions

  • Primary accession
    P21965
  • Secondary accessions
    • D6W0N8

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00000863172-375Protein kinase MCK1
Modified residue198Phosphoserine
Modified residue199Phosphotyrosine
Modified residue202Phosphoserine

Post-translational modification

Phosphorylated at tyrosine and serine.

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P21965CDC14 Q006842EBI-10517, EBI-4192
BINARY P21965UBR1 P198123EBI-10517, EBI-19909

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-327Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    375
  • Mass (Da)
    43,136
  • Last updated
    1991-08-01 v1
  • Checksum
    BCF0C776B6E3841B
MSTEEQNGVPLQRGSEFIADDVTSNKSNNTRRMLVKEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKSRELQILRIADHPNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFFNELRNDDTFLPRGFTEPIKLPNLFDFNDFELQILGEFADKIKPTKVAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X55054
EMBL· GenBank· DDBJ
CAA38895.1
EMBL· GenBank· DDBJ
Genomic DNA
M55984
EMBL· GenBank· DDBJ
AAA34764.1
EMBL· GenBank· DDBJ
Genomic DNA
Z46259
EMBL· GenBank· DDBJ
CAA86388.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71583
EMBL· GenBank· DDBJ
CAA96236.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71582
EMBL· GenBank· DDBJ
CAA96235.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006947
EMBL· GenBank· DDBJ
DAA10254.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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