P21918 · DRD5_HUMAN

  • Protein
    D(1B) dopamine receptor
  • Gene
    DRD5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbrush border membrane
Cellular Componentciliary membrane
Cellular Componentcilium
Cellular Componentnon-motile cilium
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular Functiondopamine binding
Molecular Functiondopamine neurotransmitter receptor activity
Molecular Functiondopamine neurotransmitter receptor activity, coupled via Gs
Molecular FunctionG protein-coupled receptor activity
Biological Processactivation of adenylate cyclase activity
Biological Processadenylate cyclase-activating adrenergic receptor signaling pathway
Biological Processadenylate cyclase-activating dopamine receptor signaling pathway
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processassociative learning
Biological Processcellular response to catecholamine stimulus
Biological Processchemical synaptic transmission
Biological ProcessG protein-coupled dopamine receptor signaling pathway
Biological Processintracellular calcium ion homeostasis
Biological Processlong-term synaptic depression
Biological Processnegative regulation of blood pressure
Biological Processnegative regulation of NAD(P)H oxidase activity
Biological Processnorepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
Biological Processphospholipase C-activating dopamine receptor signaling pathway
Biological Processpositive regulation of adenylate cyclase activity
Biological Processpositive regulation of MAPK cascade
Biological Processreactive oxygen species metabolic process
Biological Processregulation of female receptivity
Biological Processregulation of systemic arterial blood pressure by vasopressin
Biological Processresponse to amphetamine
Biological Processresponse to cocaine
Biological Processsensitization
Biological Processsynaptic transmission, dopaminergic
Biological Processtransmission of nerve impulse
Biological Processwound healing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D(1B) dopamine receptor
  • Alternative names
    • D(5) dopamine receptor
    • D1beta dopamine receptor
    • Dopamine D5 receptor

Gene names

    • Name
      DRD5
    • Synonyms
      DRD1B, DRD1L2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P21918
  • Secondary accessions
    • B2R9S3
    • Q8NEQ8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-39Extracellular
Transmembrane40-66Helical; Name=1
Topological domain67-77Cytoplasmic
Transmembrane78-104Helical; Name=2
Topological domain105-114Extracellular
Transmembrane115-136Helical; Name=3
Topological domain137-158Cytoplasmic
Transmembrane159-180Helical; Name=4
Topological domain181-223Extracellular
Transmembrane224-246Helical; Name=5
Topological domain247-296Cytoplasmic
Transmembrane297-320Helical; Name=6
Topological domain321-340Extracellular
Transmembrane341-360Helical; Name=7
Topological domain361-477Cytoplasmic

Keywords

Disease & Variants

Involvement in disease

Benign essential blepharospasm (BEB)

  • Note
    • Disease susceptibility may be associated with variants affecting the gene represented in this entry
  • Description
    A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
  • See also
    MIM:606798

Features

Showing features for mutagenesis, natural variant.

TypeIDPosition(s)Description
Mutagenesis7Impairs subcellular location.
Natural variantVAR_02921062in dbSNP:rs2227840
Natural variantVAR_01183788in dbSNP:rs6282
Natural variantVAR_029211110in dbSNP:rs2227849
Natural variantVAR_029212207in dbSNP:rs2227845
Natural variantVAR_029213233in dbSNP:rs2227843
Natural variantVAR_024254238in dbSNP:rs2227852
Natural variantVAR_003458269in dbSNP:rs538877978
Natural variantVAR_029215286in dbSNP:rs2227850
Natural variantVAR_061217297in dbSNP:rs2227851
Natural variantVAR_003459330in dbSNP:rs1800762
Natural variantVAR_003460351in dbSNP:rs1577263526
Natural variantVAR_003461453in dbSNP:rs776114395

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 799 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, lipidation.

TypeIDPosition(s)Description
ChainPRO_00000694051-477D(1B) dopamine receptor
Glycosylation7N-linked (GlcNAc...) asparagine
Disulfide bond113↔217
Glycosylation222N-linked (GlcNAc...) asparagine
Lipidation375S-palmitoyl cysteine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Neuron-specific, localized primarily within limbic regions of the brain.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P21918NOTCH2NLC P0DPK43EBI-12139313, EBI-22310682

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    52,951
  • Last updated
    1992-03-01 v2
  • Checksum
    BACCB85E5A72F9CA
MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X58454
EMBL· GenBank· DDBJ
CAA41360.1
EMBL· GenBank· DDBJ
Genomic DNA
M67439
EMBL· GenBank· DDBJ
AAA52329.1
EMBL· GenBank· DDBJ
Genomic DNA
AY136750
EMBL· GenBank· DDBJ
AAN01276.1
EMBL· GenBank· DDBJ
mRNA
AK313897
EMBL· GenBank· DDBJ
BAG36620.1
EMBL· GenBank· DDBJ
mRNA
CH471069
EMBL· GenBank· DDBJ
EAW92679.1
EMBL· GenBank· DDBJ
Genomic DNA
BC009748
EMBL· GenBank· DDBJ
AAH09748.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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