P21918 · DRD5_HUMAN
- ProteinD(1B) dopamine receptor
- GeneDRD5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids477 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameD(1B) dopamine receptor
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP21918
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-39 | Extracellular | ||||
Sequence: MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPS | ||||||
Transmembrane | 40-66 | Helical; Name=1 | ||||
Sequence: QVVTACLLTLLIIWTLLGNVLVCAAIV | ||||||
Topological domain | 67-77 | Cytoplasmic | ||||
Sequence: RSRHLRANMTN | ||||||
Transmembrane | 78-104 | Helical; Name=2 | ||||
Sequence: VFIVSLAVSDLFVALLVMPWKAVAEVA | ||||||
Topological domain | 105-114 | Extracellular | ||||
Sequence: GYWPFGAFCD | ||||||
Transmembrane | 115-136 | Helical; Name=3 | ||||
Sequence: VWVAFDIMCSTASILNLCVISV | ||||||
Topological domain | 137-158 | Cytoplasmic | ||||
Sequence: DRYWAISRPFRYKRKMTQRMAL | ||||||
Transmembrane | 159-180 | Helical; Name=4 | ||||
Sequence: VMVGLAWTLSILISFIPVQLNW | ||||||
Topological domain | 181-223 | Extracellular | ||||
Sequence: HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNR | ||||||
Transmembrane | 224-246 | Helical; Name=5 | ||||
Sequence: TYAISSSLISFYIPVAIMIVTYT | ||||||
Topological domain | 247-296 | Cytoplasmic | ||||
Sequence: RIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLK | ||||||
Transmembrane | 297-320 | Helical; Name=6 | ||||
Sequence: TLSVIMGVFVCCWLPFFILNCMVP | ||||||
Topological domain | 321-340 | Extracellular | ||||
Sequence: FCSGHPEGPPAGFPCVSETT | ||||||
Transmembrane | 341-360 | Helical; Name=7 | ||||
Sequence: FDVFVWFGWANSSLNPVIYA | ||||||
Topological domain | 361-477 | Cytoplasmic | ||||
Sequence: FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Benign essential blepharospasm (BEB)
- Note
- DescriptionA primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
- See alsoMIM:606798
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 7 | Impairs subcellular location. | ||||
Sequence: N → Q | ||||||
Natural variant | VAR_029210 | 62 | in dbSNP:rs2227840 | |||
Sequence: C → S | ||||||
Natural variant | VAR_011837 | 88 | in dbSNP:rs6282 | |||
Sequence: L → R | ||||||
Natural variant | VAR_029211 | 110 | in dbSNP:rs2227849 | |||
Sequence: G → E | ||||||
Natural variant | VAR_029212 | 207 | in dbSNP:rs2227845 | |||
Sequence: F → V | ||||||
Natural variant | VAR_029213 | 233 | in dbSNP:rs2227843 | |||
Sequence: S → N | ||||||
Natural variant | VAR_024254 | 238 | in dbSNP:rs2227852 | |||
Sequence: V → I | ||||||
Natural variant | VAR_003458 | 269 | in dbSNP:rs538877978 | |||
Sequence: A → V | ||||||
Natural variant | VAR_029215 | 286 | in dbSNP:rs2227850 | |||
Sequence: A → V | ||||||
Natural variant | VAR_061217 | 297 | in dbSNP:rs2227851 | |||
Sequence: T → P | ||||||
Natural variant | VAR_003459 | 330 | in dbSNP:rs1800762 | |||
Sequence: P → Q | ||||||
Natural variant | VAR_003460 | 351 | in dbSNP:rs1577263526 | |||
Sequence: N → D | ||||||
Natural variant | VAR_003461 | 453 | in dbSNP:rs776114395 | |||
Sequence: S → C |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 799 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069405 | 1-477 | D(1B) dopamine receptor | |||
Sequence: MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH | ||||||
Glycosylation | 7 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 113↔217 | |||||
Sequence: CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC | ||||||
Glycosylation | 222 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 375 | S-palmitoyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P21918 | NOTCH2NLC P0DPK4 | 3 | EBI-12139313, EBI-22310682 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length477
- Mass (Da)52,951
- Last updated1992-03-01 v2
- ChecksumBACCB85E5A72F9CA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X58454 EMBL· GenBank· DDBJ | CAA41360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M67439 EMBL· GenBank· DDBJ | AAA52329.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136750 EMBL· GenBank· DDBJ | AAN01276.1 EMBL· GenBank· DDBJ | mRNA | ||
AK313897 EMBL· GenBank· DDBJ | BAG36620.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471069 EMBL· GenBank· DDBJ | EAW92679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC009748 EMBL· GenBank· DDBJ | AAH09748.1 EMBL· GenBank· DDBJ | mRNA |