P21890 · FENR_NOSSO
- ProteinFerredoxin--NADP reductase
- GenepetH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids440 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 214-217 | FAD (UniProtKB | ChEBI) | ||||
Sequence: RLYS | ||||||
Binding site | 217 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 235-237 | FAD (UniProtKB | ChEBI) | ||||
Sequence: CVR | ||||||
Binding site | 237 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 241 | FAD (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 253-255 | FAD (UniProtKB | ChEBI) | ||||
Sequence: VCS | ||||||
Binding site | 294 | FAD (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 294 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 330-331 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: VP | ||||||
Binding site | 360-361 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: SR | ||||||
Binding site | 370-374 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: RMYIQ | ||||||
Binding site | 399-400 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GL | ||||||
Binding site | 438 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | phycobilisome | |
Cellular Component | plasma membrane-derived thylakoid membrane | |
Molecular Function | ferredoxin-NADP+ reductase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | NADP binding | |
Molecular Function | NADPH dehydrogenase activity | |
Biological Process | electron transport chain |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFerredoxin--NADP reductase
- EC number
- Short namesFNR
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Nostocaceae > Nostoc
Accessions
- Primary accessionP21890
Subcellular Location
UniProt Annotation
GO Annotation
Cellular thylakoid membrane ; Peripheral membrane protein
Note: May be bound to the thylakoid membrane or anchored to the thylakoid-bound phycobilisomes.
Keywords
- Cellular component
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000167632 | 1-440 | Ferredoxin--NADP reductase | |||
Sequence: MSNQGAFDGAANVESGSRVFVYEVVGMRQNEETDQTNYPIRKSGSVFIRVPYNRMNQEMQRITRLGGKIVTIQTVSALQQLNGRTTIATVTDASSEIAKSEGNGKATPVKTDSGAKAFAKPPAEEQLKKKDNKGNTMTQAKAKHADVPVNLYRPNAPFIGKVISNEPLVKEGGIGIVQHIKFDLTGGNLKYIEGQSIGIIPPGVDKNGKPEKLRLYSIASTRHGDDVDDKTISLCVRQLEYKHPESGETVYGVCSTYLTHIEPGSEVKITGPVGKEMLLPDDPEANVIMLATGTGIAPMRTYLWRMFKDAERAANPEYQFKGFSWLVFGVPTTPNILYKEELEEIQQKYPDNFRLTYAISREQKNPQGGRMYIQDRVAEHADELWQLIKNQKTHTYICGLRGMEEGIDAALSAAAAKEGVTWSDYQKDLKKAGRWHVETY |
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P21890 | isiB P0A3E0 | 5 | EBI-593915, EBI-593907 | |
BINARY | P21890 | petF P0A3C8 | 5 | EBI-593915, EBI-637080 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-75 | CpcD-like | ||||
Sequence: SRVFVYEVVGMRQNEETDQTNYPIRKSGSVFIRVPYNRMNQEMQRITRLGGKIVTIQTV | ||||||
Region | 99-142 | Disordered | ||||
Sequence: KSEGNGKATPVKTDSGAKAFAKPPAEEQLKKKDNKGNTMTQAKA | ||||||
Compositional bias | 122-137 | Basic and acidic residues | ||||
Sequence: PAEEQLKKKDNKGNTM | ||||||
Domain | 155-279 | FAD-binding FR-type | ||||
Sequence: NAPFIGKVISNEPLVKEGGIGIVQHIKFDLTGGNLKYIEGQSIGIIPPGVDKNGKPEKLRLYSIASTRHGDDVDDKTISLCVRQLEYKHPESGETVYGVCSTYLTHIEPGSEVKITGPVGKEMLL |
Sequence similarities
Belongs to the ferredoxin--NADP reductase type 1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length440
- Mass (Da)48,865
- Last updated1994-10-01 v2
- Checksum8E1F61D0F09338B6
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 122-137 | Basic and acidic residues | ||||
Sequence: PAEEQLKKKDNKGNTM | ||||||
Sequence conflict | 180 | in Ref. 3; AA sequence | ||||
Sequence: I → L |
Keywords
- Technical term