P21850 · DA2D_PHYBI

Function

function

Deltorphin is a heptapeptide with a very potent opiate-like activity. Has high affinity and selectivity for delta-type opioid receptors. The two dermorphin-like peptides have a similar affinity and selectivity for the mu opioid receptor as dermorphin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionopioid peptide activity
Biological Processdefense response
Biological Processneuropeptide signaling pathway

Keywords

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    P21850

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant53-54in clone AD3
Natural variant120-227in clone AD7
Natural variant156-227in clone AD8

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, propeptide, peptide, modified residue.

TypeIDPosition(s)Description
Signal1-20
PropeptidePRO_000001020421-46
PeptidePRO_000001020549-55[D-Ala2]-dermorphin-like 1
Modified residue50D-alanine (Ala)
PropeptidePRO_000001020657-75
PeptidePRO_000001020778-83[D-Ala2]-dermorphin-like 2
Modified residue79D-alanine (Ala)
PropeptidePRO_000001020886-104
PeptidePRO_0000010209107-113[D-Ala2]-deltorphin-2
Modified residue108D-alanine (Ala)
Modified residue113Glycine amide
PropeptidePRO_0000010210115-140
PeptidePRO_0000010211143-149[D-Ala2]-deltorphin-1
Modified residue144D-alanine (Ala)
Modified residue149Glycine amide
PropeptidePRO_0000010212151-176
PeptidePRO_0000010213179-185[D-Ala2]-deltorphin-1
Modified residue180D-alanine (Ala)
Modified residue185Glycine amide
PropeptidePRO_0000010214187-212
PeptidePRO_0000010215215-221[D-Ala2]-deltorphin-1
Modified residue216D-alanine (Ala)
Modified residue221Glycine amide
PropeptidePRO_0000010216223-227

Keywords

Expression

Tissue specificity

Expressed by the skin glands.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region22-227Disordered
Compositional bias70-88Basic and acidic residues
Compositional bias98-127Basic and acidic residues
Compositional bias134-163Basic and acidic residues
Compositional bias170-199Basic and acidic residues
Compositional bias206-227Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    227
  • Mass (Da)
    26,934
  • Last updated
    1991-05-01 v1
  • Checksum
    08CE573BAE362130
MSFLKKSLLLVLFLGLVSHSVCKEEKRETEEENENEEENHEVGSEMKRYAFWYPNRDTEEKNENEEENQEEGSEMKRYAFGYPKREPEEENENEEENHEEGSEMKRYAFEVVGGEAKKMKREPEEENENEEENHEEGSEMKRYAFDVVGGEAKKMKREPEEENENEEENHEEGSEMKRYAFDVVGGEAKKMKREPEEENENEEENHEEGSEMKRYAFDVVGGEAKKM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias70-88Basic and acidic residues
Compositional bias98-127Basic and acidic residues
Compositional bias134-163Basic and acidic residues
Compositional bias170-199Basic and acidic residues
Compositional bias206-227Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M34560
EMBL· GenBank· DDBJ
AAA49451.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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