P21822 · MCPS_KLEAK
- ProteinMethyl-accepting chemotaxis serine transducer
- Genetse
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids556 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Receptor for the attractant L-serine and related amino acids.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | transmembrane signaling receptor activity | |
Biological Process | chemotaxis | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMethyl-accepting chemotaxis serine transducer
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionP21822
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-9 | Cytoplasmic | ||||
Sequence: MFNRIKVVT | ||||||
Transmembrane | 10-30 | Helical | ||||
Sequence: SLLLVLVLFGALQLISGGLFF | ||||||
Topological domain | 31-191 | Periplasmic | ||||
Sequence: SSLKSDKENFTVLQTIRQQQLLLSESRVDLLQARNSLNRAGIRYMMDTNKIGSGATIDELLAKAKEELARAERNYTAYEKIPQDPRQDPQATEKLKQQYGILYGALSELIQLLGEGKINAFFDQPTQKYQDDFEQTYNAYLQQNGKLYQIAVDASNSSYSS | ||||||
Transmembrane | 192-212 | Helical | ||||
Sequence: AIWTLIVVIIVVLAAIVGVWM | ||||||
Topological domain | 213-556 | Cytoplasmic | ||||
Sequence: GIHHILVRPLNRMIEHIKRIASGDLTQPIPVTSRNEIGVLAASLKHMQNELIETVSGVRQGADAIYSGASEIAAGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASQLALSASETAQKGGKVVANVVETMHDIASSSQKIADITGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAKEIKALIEDSVNRVDMGSVLVESAGDTMGDIVNAVTRVTDIMGEIASASDEQSRGIDQVGQAVAEMDRVTQQNASLVEESASAAAALEEQASLLTQSVAVFRLKSEGQEEYKAPVSNKTAPAAIATHKKTSASDYQDNWETF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000110543 | 1-556 | Methyl-accepting chemotaxis serine transducer | |||
Sequence: MFNRIKVVTSLLLVLVLFGALQLISGGLFFSSLKSDKENFTVLQTIRQQQLLLSESRVDLLQARNSLNRAGIRYMMDTNKIGSGATIDELLAKAKEELARAERNYTAYEKIPQDPRQDPQATEKLKQQYGILYGALSELIQLLGEGKINAFFDQPTQKYQDDFEQTYNAYLQQNGKLYQIAVDASNSSYSSAIWTLIVVIIVVLAAIVGVWMGIHHILVRPLNRMIEHIKRIASGDLTQPIPVTSRNEIGVLAASLKHMQNELIETVSGVRQGADAIYSGASEIAAGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASQLALSASETAQKGGKVVANVVETMHDIASSSQKIADITGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAKEIKALIEDSVNRVDMGSVLVESAGDTMGDIVNAVTRVTDIMGEIASASDEQSRGIDQVGQAVAEMDRVTQQNASLVEESASAAAALEEQASLLTQSVAVFRLKSEGQEEYKAPVSNKTAPAAIATHKKTSASDYQDNWETF | ||||||
Modified residue | 297 | Glutamate methyl ester (Gln) | ||||
Sequence: Q | ||||||
Modified residue | 304 | Glutamate methyl ester (Glu) | ||||
Sequence: E | ||||||
Modified residue | 311 | Glutamate methyl ester (Gln) | ||||
Sequence: Q | ||||||
Modified residue | 493 | Glutamate methyl ester (Glu) | ||||
Sequence: E | ||||||
Modified residue | 502 | Glutamate methyl ester (Glu) | ||||
Sequence: E |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 64-73 | The 3 Arg may form a positively charged pocket, which binds the alpha-carboxyl group of the attractant AA | ||||
Sequence: RNSLNRAGIR | ||||||
Domain | 216-268 | HAMP | ||||
Sequence: HILVRPLNRMIEHIKRIASGDLTQPIPVTSRNEIGVLAASLKHMQNELIETVS | ||||||
Domain | 273-502 | Methyl-accepting transducer | ||||
Sequence: GADAIYSGASEIAAGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASQLALSASETAQKGGKVVANVVETMHDIASSSQKIADITGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAKEIKALIEDSVNRVDMGSVLVESAGDTMGDIVNAVTRVTDIMGEIASASDEQSRGIDQVGQAVAEMDRVTQQNASLVEESASAAAALE |
Sequence similarities
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length556
- Mass (Da)60,038
- Last updated2011-12-14 v2
- ChecksumF2DE0FCA1865C9A5
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 35 | in Ref. 1; AAA24797 | ||||
Sequence: S → G | ||||||
Sequence conflict | 94 | in Ref. 1; AAA24797 | ||||
Sequence: A → AE | ||||||
Sequence conflict | 97 | in Ref. 1; AAA24797 | ||||
Sequence: E → K | ||||||
Sequence conflict | 145-146 | in Ref. 1; AAA24797 | ||||
Sequence: EG → GGC | ||||||
Sequence conflict | 276-279 | in Ref. 1; AAA24797 | ||||
Sequence: AIYS → RSID | ||||||
Sequence conflict | 284 | in Ref. 1; AAA24797 | ||||
Sequence: I → S | ||||||
Sequence conflict | 301 | in Ref. 1; AAA24797 | ||||
Sequence: S → A | ||||||
Sequence conflict | 370 | in Ref. 1; AAA24797 | ||||
Sequence: G → V | ||||||
Sequence conflict | 395 | in Ref. 1; AAA24797 | ||||
Sequence: G → A | ||||||
Sequence conflict | 478 | in Ref. 1; AAA24797 | ||||
Sequence: A → R | ||||||
Sequence conflict | 500 | in Ref. 1; AAA24797 | ||||
Sequence: Missing |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M26411 EMBL· GenBank· DDBJ | AAA24797.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002824 EMBL· GenBank· DDBJ | AEG98018.1 EMBL· GenBank· DDBJ | Genomic DNA |