P21633 · COBC_SINSX

  • Protein
    Threonine-phosphate decarboxylase
  • Gene
    cobC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

Caution

Was originally thought to originate from Pseudomonas denitrificans, but similarity searches show that the sequence is much closer to Sinorhizobium. The entry's taxonomy has been changed.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionpyridoxal phosphate binding
Molecular Functionthreonine-phosphate decarboxylase activity
Biological Processcobalamin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Threonine-phosphate decarboxylase
  • EC number
  • Alternative names
    • L-threonine-O-3-phosphate decarboxylase

Gene names

    • Name
      cobC

Organism names

  • Taxonomic identifier
  • Strain
    • SC510
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium

Accessions

  • Primary accession
    P21633

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001239211-333Threonine-phosphate decarboxylase
Modified residue199N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    35,014
  • Last updated
    1991-05-01 v1
  • Checksum
    DFCA4361B69B6DDB
MSAPIVHGGGITEAAARYGGRPEDWLDLSTGINPCPVALPAVPERAWHRLPDRQTVDDARSAAADYYRTNGVLPLPVPGTQSVIQLLPRLAPANRHVAIFGPTYGEYARVLEAAGFAVDRVADADALTAEHGLVIVVNPNNPTGRALAPAELLAIAARQKASGGLLLVDEAFGDLEPQLSVAGHASGQGNLIVFRSFGKFFGLAGLRLGFVVATEPVLASFADWLGPWAVSGPALTISKALMQGDTKAIAAGILERRAGLDAALDGAGLNRIGGTGLFVLVEHPRAALLQERLCEAHILTRKFDYAPTWLRVGLAPDAAGDRRLADALARMEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M59236
EMBL· GenBank· DDBJ
AAA25775.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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