P21633 · COBC_SINSX
- ProteinThreonine-phosphate decarboxylase
- GenecobC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids333 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
Catalytic activity
- H+ + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2
Cofactor
Pathway
Cofactor biosynthesis; adenosylcobalamin biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | threonine-phosphate decarboxylase activity | |
Biological Process | cobalamin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThreonine-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium
Accessions
- Primary accessionP21633
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000123921 | 1-333 | Threonine-phosphate decarboxylase | |||
Sequence: MSAPIVHGGGITEAAARYGGRPEDWLDLSTGINPCPVALPAVPERAWHRLPDRQTVDDARSAAADYYRTNGVLPLPVPGTQSVIQLLPRLAPANRHVAIFGPTYGEYARVLEAAGFAVDRVADADALTAEHGLVIVVNPNNPTGRALAPAELLAIAARQKASGGLLLVDEAFGDLEPQLSVAGHASGQGNLIVFRSFGKFFGLAGLRLGFVVATEPVLASFADWLGPWAVSGPALTISKALMQGDTKAIAAGILERRAGLDAALDGAGLNRIGGTGLFVLVEHPRAALLQERLCEAHILTRKFDYAPTWLRVGLAPDAAGDRRLADALARMEL | ||||||
Modified residue | 199 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length333
- Mass (Da)35,014
- Last updated1991-05-01 v1
- ChecksumDFCA4361B69B6DDB