P21441 · MDR_LEITA
- ProteinMultidrug resistance protein
- GenePGPA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1548 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Miscellaneous
In this organism, this protein is encoded by a gene, located in 'H circle', a 68 kb duplex DNA circle containing a 30 kb inverted repeat. Acquired resistance to methotrexate in the organism is associated with the amplification of h circles with increasing level of LTPGPA gene transcription.
Catalytic activity
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ABC-type xenobiotic transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMultidrug resistance protein
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania > lizard Leishmania
Accessions
- Primary accessionP21441
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-238 | Cytoplasmic | ||||
Sequence: MVDNGHVTIAMADLGTVVEIAQVRCQQEAQRKFAEQLDELWGGEPAYTPTVEDQASWFQQLYYGWIGDYIYKAAAGNITEADLPPPTRSTRTYHIGRKLSRQAHADIDASRRWQGYIGCEVVYKSEAEAKGVLRWVGHLQQSDYPRSLVAGVEWRMPPRHRRLAVLGSAAALHNGVVHGERLFWPHEDNYLCSCEPVEQLYVKSKYNLIPPRPPPSPDLLRTLFKVHWYHVWAQILPK | ||||||
Transmembrane | 239-256 | Helical | ||||
Sequence: LLSDVTALMLPVLLEYFV | ||||||
Transmembrane | 266-287 | Helical | ||||
Sequence: WGWGLGLALTIFLTNVIQSCSA | ||||||
Transmembrane | 349-367 | Helical | ||||
Sequence: VMYFWSAPLQLVLCLLLLI | ||||||
Transmembrane | 375-392 | Helical | ||||
Sequence: VPGMAVLFVTLPLQAVIS | ||||||
Transmembrane | 463-480 | Helical | ||||
Sequence: ATPTLVIAVVFILYHVSG | ||||||
Transmembrane | 500-519 | Helical | ||||
Sequence: VSFFMIPIIISSILQCFVSA | ||||||
Topological domain | 520-932 | Cytoplasmic | ||||
Sequence: KRVTAFIECPDTHSQVQDIASIDVPDAAAIFKGASIHTYLPVKLPRCKSRLTAMQRSTLWFRRRGVPETEWYEVDSPDASASSLAVHSTTVHMGSTQTVITDSDGAAGEDEKGEVEEGDREYYQLVSKELLRNVSLTIPKGKLTMVIGSTGSGKSTLLGALMGEYSVESGELWAERSIAYVPQQAWIMNATLRGNILFFDEERAEDLQDVIRCCQLEADLAQFCGGLDTEIGEMGVNLSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGQRIVQDVILGRLRGKTRVLATHQIHLLPLADYIVVLQHGSIVFAGDFAAFSATALEETLRGELKGSKDVESCSSDVDTESATAETAPYVAKAKGLNAEQETSLAGGEDPLRSDVEAGRLMTTEEKATGKVPWSTYVAYLK | ||||||
Transmembrane | 933-950 | Helical | ||||
Sequence: SCGGLEAWGCLLATFALT | ||||||
Transmembrane | 975-993 | Helical | ||||
Sequence: TYLYVYLFIVFLEIFGSPL | ||||||
Transmembrane | 1051-1070 | Helical | ||||
Sequence: GYLYLLEYFFSMCSTVIIMV | ||||||
Transmembrane | 1072-1088 | Helical | ||||
Sequence: VQPFVLVAIVPCVYSYY | ||||||
Transmembrane | 1164-1182 | Helical | ||||
Sequence: LEFLSCVVTFMVAFIGVIG | ||||||
Transmembrane | 1186-1205 | Helical | ||||
Sequence: GASSQNIGLISLSLTMSMTL | ||||||
Topological domain | 1206-1548 | Cytoplasmic | ||||
Sequence: TETLNWLVRQVAMVEANMNSVERVLHYTQEVEHEHVPEMGELVAQLVRSESGRGANVTETVVIESAGAASSALHPVQAGSLVLEGVQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGVIHVNGREMSAYGLRDVRRHFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESEGIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNHQSMFHSMVESLGSRGSKDFYELLMGRRIVQPAVLSD |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000093346 | 1-1548 | Multidrug resistance protein | |||
Sequence: MVDNGHVTIAMADLGTVVEIAQVRCQQEAQRKFAEQLDELWGGEPAYTPTVEDQASWFQQLYYGWIGDYIYKAAAGNITEADLPPPTRSTRTYHIGRKLSRQAHADIDASRRWQGYIGCEVVYKSEAEAKGVLRWVGHLQQSDYPRSLVAGVEWRMPPRHRRLAVLGSAAALHNGVVHGERLFWPHEDNYLCSCEPVEQLYVKSKYNLIPPRPPPSPDLLRTLFKVHWYHVWAQILPKLLSDVTALMLPVLLEYFVKYLNADNATWGWGLGLALTIFLTNVIQSCSAHKYDHISIRTAALFETSSMALLFEKCFTVSRRSLQRPDMSVGRIMNMVGNDVDNIGSLNWYVMYFWSAPLQLVLCLLLLIRLVGWLRVPGMAVLFVTLPLQAVISKHVQDVSERMASVVDLRIKRTNELLSGVRIVKFMGWEPVFLARIQDARSRELRCLRDVHVANVFFMFVNDATPTLVIAVVFILYHVSGKVLKPEVVFPTIALLNTMRVSFFMIPIIISSILQCFVSAKRVTAFIECPDTHSQVQDIASIDVPDAAAIFKGASIHTYLPVKLPRCKSRLTAMQRSTLWFRRRGVPETEWYEVDSPDASASSLAVHSTTVHMGSTQTVITDSDGAAGEDEKGEVEEGDREYYQLVSKELLRNVSLTIPKGKLTMVIGSTGSGKSTLLGALMGEYSVESGELWAERSIAYVPQQAWIMNATLRGNILFFDEERAEDLQDVIRCCQLEADLAQFCGGLDTEIGEMGVNLSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGQRIVQDVILGRLRGKTRVLATHQIHLLPLADYIVVLQHGSIVFAGDFAAFSATALEETLRGELKGSKDVESCSSDVDTESATAETAPYVAKAKGLNAEQETSLAGGEDPLRSDVEAGRLMTTEEKATGKVPWSTYVAYLKSCGGLEAWGCLLATFALTECVTAASSVWLSIWSTGSLMWSADTYLYVYLFIVFLEIFGSPLRFFLCYYLIRIGSRNMHRDLLESIGVARMSFFDTTPVGRVLNRFTKDMSILDNTLNDGYLYLLEYFFSMCSTVIIMVVVQPFVLVAIVPCVYSYYKLMQVYNASNRETRRIKSIAHSPVFTLLEESLQGQRTIATYGKLHLVLQEALGRLDVVYSALYMQNVSNRWLGVRLEFLSCVVTFMVAFIGVIGKMEGASSQNIGLISLSLTMSMTLTETLNWLVRQVAMVEANMNSVERVLHYTQEVEHEHVPEMGELVAQLVRSESGRGANVTETVVIESAGAASSALHPVQAGSLVLEGVQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGVIHVNGREMSAYGLRDVRRHFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESEGIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNHQSMFHSMVESLGSRGSKDFYELLMGRRIVQPAVLSD | ||||||
Glycosylation | 263 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1095 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1154 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 231-514 | ABC transmembrane type-1 1 | ||||
Sequence: VWAQILPKLLSDVTALMLPVLLEYFVKYLNADNATWGWGLGLALTIFLTNVIQSCSAHKYDHISIRTAALFETSSMALLFEKCFTVSRRSLQRPDMSVGRIMNMVGNDVDNIGSLNWYVMYFWSAPLQLVLCLLLLIRLVGWLRVPGMAVLFVTLPLQAVISKHVQDVSERMASVVDLRIKRTNELLSGVRIVKFMGWEPVFLARIQDARSRELRCLRDVHVANVFFMFVNDATPTLVIAVVFILYHVSGKVLKPEVVFPTIALLNTMRVSFFMIPIIISSILQ | ||||||
Domain | 634-855 | ABC transporter 1 | ||||
Sequence: VEEGDREYYQLVSKELLRNVSLTIPKGKLTMVIGSTGSGKSTLLGALMGEYSVESGELWAERSIAYVPQQAWIMNATLRGNILFFDEERAEDLQDVIRCCQLEADLAQFCGGLDTEIGEMGVNLSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGQRIVQDVILGRLRGKTRVLATHQIHLLPLADYIVVLQHGSIVFAGDFAAFSATALEETLRGEL | ||||||
Domain | 940-1221 | ABC transmembrane type-1 2 | ||||
Sequence: WGCLLATFALTECVTAASSVWLSIWSTGSLMWSADTYLYVYLFIVFLEIFGSPLRFFLCYYLIRIGSRNMHRDLLESIGVARMSFFDTTPVGRVLNRFTKDMSILDNTLNDGYLYLLEYFFSMCSTVIIMVVVQPFVLVAIVPCVYSYYKLMQVYNASNRETRRIKSIAHSPVFTLLEESLQGQRTIATYGKLHLVLQEALGRLDVVYSALYMQNVSNRWLGVRLEFLSCVVTFMVAFIGVIGKMEGASSQNIGLISLSLTMSMTLTETLNWLVRQVAMVEA | ||||||
Domain | 1286-1521 | ABC transporter 2 | ||||
Sequence: LVLEGVQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGVIHVNGREMSAYGLRDVRRHFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESEGIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNHQSMFHSMVE |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,548
- Mass (Da)172,236
- Last updated1995-11-01 v2
- ChecksumAFE4CC405C77B2EA