P21441 · MDR_LEITA

Function

Miscellaneous

In this organism, this protein is encoded by a gene, located in 'H circle', a 68 kb duplex DNA circle containing a 30 kb inverted repeat. Acquired resistance to methotrexate in the organism is associated with the amplification of h circles with increasing level of LTPGPA gene transcription.

Catalytic activity

  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

115482004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site667-674ATP 1 (UniProtKB | ChEBI)
Binding site1320-1327ATP 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular FunctionABC-type xenobiotic transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Multidrug resistance protein
  • EC number
  • Alternative names
    • P-glycoprotein

Gene names

    • Name
      PGPA

Organism names

Accessions

  • Primary accession
    P21441

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-238Cytoplasmic
Transmembrane239-256Helical
Transmembrane266-287Helical
Transmembrane349-367Helical
Transmembrane375-392Helical
Transmembrane463-480Helical
Transmembrane500-519Helical
Topological domain520-932Cytoplasmic
Transmembrane933-950Helical
Transmembrane975-993Helical
Transmembrane1051-1070Helical
Transmembrane1072-1088Helical
Transmembrane1164-1182Helical
Transmembrane1186-1205Helical
Topological domain1206-1548Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000933461-1548Multidrug resistance protein
Glycosylation263N-linked (GlcNAc...) asparagine
Glycosylation1095N-linked (GlcNAc...) asparagine
Glycosylation1154N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain231-514ABC transmembrane type-1 1
Domain634-855ABC transporter 1
Domain940-1221ABC transmembrane type-1 2
Domain1286-1521ABC transporter 2

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,548
  • Mass (Da)
    172,236
  • Last updated
    1995-11-01 v2
  • Checksum
    AFE4CC405C77B2EA
MVDNGHVTIAMADLGTVVEIAQVRCQQEAQRKFAEQLDELWGGEPAYTPTVEDQASWFQQLYYGWIGDYIYKAAAGNITEADLPPPTRSTRTYHIGRKLSRQAHADIDASRRWQGYIGCEVVYKSEAEAKGVLRWVGHLQQSDYPRSLVAGVEWRMPPRHRRLAVLGSAAALHNGVVHGERLFWPHEDNYLCSCEPVEQLYVKSKYNLIPPRPPPSPDLLRTLFKVHWYHVWAQILPKLLSDVTALMLPVLLEYFVKYLNADNATWGWGLGLALTIFLTNVIQSCSAHKYDHISIRTAALFETSSMALLFEKCFTVSRRSLQRPDMSVGRIMNMVGNDVDNIGSLNWYVMYFWSAPLQLVLCLLLLIRLVGWLRVPGMAVLFVTLPLQAVISKHVQDVSERMASVVDLRIKRTNELLSGVRIVKFMGWEPVFLARIQDARSRELRCLRDVHVANVFFMFVNDATPTLVIAVVFILYHVSGKVLKPEVVFPTIALLNTMRVSFFMIPIIISSILQCFVSAKRVTAFIECPDTHSQVQDIASIDVPDAAAIFKGASIHTYLPVKLPRCKSRLTAMQRSTLWFRRRGVPETEWYEVDSPDASASSLAVHSTTVHMGSTQTVITDSDGAAGEDEKGEVEEGDREYYQLVSKELLRNVSLTIPKGKLTMVIGSTGSGKSTLLGALMGEYSVESGELWAERSIAYVPQQAWIMNATLRGNILFFDEERAEDLQDVIRCCQLEADLAQFCGGLDTEIGEMGVNLSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGQRIVQDVILGRLRGKTRVLATHQIHLLPLADYIVVLQHGSIVFAGDFAAFSATALEETLRGELKGSKDVESCSSDVDTESATAETAPYVAKAKGLNAEQETSLAGGEDPLRSDVEAGRLMTTEEKATGKVPWSTYVAYLKSCGGLEAWGCLLATFALTECVTAASSVWLSIWSTGSLMWSADTYLYVYLFIVFLEIFGSPLRFFLCYYLIRIGSRNMHRDLLESIGVARMSFFDTTPVGRVLNRFTKDMSILDNTLNDGYLYLLEYFFSMCSTVIIMVVVQPFVLVAIVPCVYSYYKLMQVYNASNRETRRIKSIAHSPVFTLLEESLQGQRTIATYGKLHLVLQEALGRLDVVYSALYMQNVSNRWLGVRLEFLSCVVTFMVAFIGVIGKMEGASSQNIGLISLSLTMSMTLTETLNWLVRQVAMVEANMNSVERVLHYTQEVEHEHVPEMGELVAQLVRSESGRGANVTETVVIESAGAASSALHPVQAGSLVLEGVQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGVIHVNGREMSAYGLRDVRRHFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESEGIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNHQSMFHSMVESLGSRGSKDFYELLMGRRIVQPAVLSD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X17154
EMBL· GenBank· DDBJ
CAA35038.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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