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Endosomal proteolysis of internalized proteins.Authier F., Posner B.I., Bergeron J.J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCFEBS Lett 389:55-60 (1996)Mapped to26
A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules.Supek F., Supekova L., Mandiyan S., Pan Y.-C.E., Nelson H., Nelson N.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCJ. Biol. Chem. 269:24102-24106 (1994)Cited in1Mapped to24
Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases.Schuermann A., Brauers A., Massmann S., Becker W., Joost H.-G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCJ. Biol. Chem. 270:28982-28988 (1995)Cited in4Mapped to52
Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining.Wang L., Wu D., Robinson C.V., Fu T.M.View abstractCategoriesStructureSourcePDB: 7U4TPubMedEurope PMCProc Natl Acad Sci U S A 119:e2203742119-e2203742119 (2022)Cited in1Mapped to20
Molecular basis of mEAK7-mediated human V-ATPase regulation.Wang R., Qin Y., Xie X.S., Li X.View abstractCategoriesStructureSourcePDB: 7UNFPubMedEurope PMCNat Commun 13:3272-3272 (2022)Cited in1Mapped to23
MITF-the first 25 years.Goding C.R., Arnheiter H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCGenes Dev 33:983-1007 (2019)Mapped to99+
MITF has a central role in regulating starvation-induced autophagy in melanoma.Moller K., Sigurbjornsdottir S., Arnthorsson A.O., Pogenberg V., Dilshat R., Fock V., Brynjolfsdottir S.H., Bindesboll C., Bessadottir M.[...], Ogmundsdottir M.H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCSci Rep 9:1055-1055 (2019)Mapped to12
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.Shen K., Valenstein M.L., Gu X., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCJ. Biol. Chem. 294:2970-2975 (2019)Cited in1Mapped to49
Insulin degradation: mechanisms, products, and significance.Duckworth W.C.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCEndocr Rev 9:319-345 (1988)Mapped to26
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.Shen K., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 115:9545-9550 (2018)Cited in6Mapped to26
A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.Lawrence R.E., Cho K.F., Rappold R., Thrun A., Tofaute M., Kim D.J., Moldavski O., Hurley J.H., Zoncu R.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCNat Cell Biol 20:1052-1063 (2018)Mapped to32
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.Yang H., Jiang X., Li B., Yang H.J., Miller M., Yang A., Dhar A., Pavletich N.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCNature 552:368-373 (2017)Cited in8Mapped to32
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.Gu X., Orozco J.M., Saxton R.A., Condon K.J., Liu G.Y., Krawczyk P.A., Scaria S.M., Harper J.W., Gygi S.P., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCScience 358:813-818 (2017)Cited in3Mapped to52
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.Shen K., Choe A., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCMol Cell 68:552-565.e8 (2017)Mapped to36
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.Wyant G.A., Abu-Remaileh M., Wolfson R.L., Chen W.W., Freinkman E., Danai L.V., Vander Heiden M.G., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCCell 171:642-654 (2017)Cited in1Mapped to33
Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.Gai Z., Wang Q., Yang C., Wang L., Deng W., Wu G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCCell Discov 2:16051-16051 (2016)Mapped to50
Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.Xia J., Wang R., Zhang T., Ding J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCCell Discov 2:16035-16035 (2016)Mapped to50
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.Saxton R.A., Chantranupong L., Knockenhauer K.E., Schwartz T.U., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCNature 536:229-233 (2016)Cited in6Mapped to44
The CASTOR proteins are arginine sensors for the mTORC1 pathway.Chantranupong L., Scaria S.M., Saxton R.A., Gygi M.P., Shen K., Wyant G.A., Wang T., Harper J.W., Gygi S.P., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCCell 165:153-164 (2016)Cited in7Mapped to44
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.Saxton R.A., Knockenhauer K.E., Wolfson R.L., Chantranupong L., Pacold M.E., Wang T., Schwartz T.U., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCScience 351:53-58 (2016)Cited in3Mapped to47
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.Hein M.Y., Hubner N.C., Poser I., Cox J., Nagaraj N., Toyoda Y., Gak I.A., Weisswange I., Mansfeld J.[...], Mann M.View abstractCategoriesInteractionSourceIntAct: P21283PubMedEurope PMCCell 163:712-723 (2015)Mapped to99+
Sestrin2 is a leucine sensor for the mTORC1 pathway.Wolfson R.L., Chantranupong L., Saxton R.A., Shen K., Scaria S.M., Cantor J.R., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCScience 351:43-48 (2016)Cited in4Mapped to47
Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1.Zhang T., Zhou Q., Ogmundsdottir M.H., Moller K., Siddaway R., Larue L., Hsing M., Kong S.W., Goding C.R.[...], Pignoni F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCJ Cell Sci 128:2938-2950 (2015)Mapped to99+
The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis.Ploper D., De Robertis E.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-912586PubMedEurope PMCPharmacol Res 99:36-43 (2015)Mapped to11