G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.Strathmann M., Simon M.I.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 87:9113-9117 (1990)Cited in21Mapped to11
Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G protein alpha subunit genes.Davignon I., Barnard M., Gavrilova O., Sweet K.K., Wilkie T.M.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA]Strain129/SvCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenomics 31:359-366 (1996)Cited in2Mapped to3
No title available.Lubec G., Kang S.U.Cited forPROTEIN SEQUENCE OF 21-27; 121-133; 159-166; 203-210; 312-338 AND 346-354, IDENTIFICATION BY MASS SPECTROMETRYStrainC57BL/6JTissueBrainCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to UniProtKB (APR-2007)Cited in99+
Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.Strathmann M., Wilkie T.M., Simon M.I.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 211-271CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 86:7407-7409 (1989)Cited in5Mapped to74
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueBrain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen, TestisCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.Offermanns S., Zhao L.P., Gohla A., Sarosi I., Simon M.I., Wilkie T.M.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 17:4304-4312 (1998)Cited in2Mapped to9
Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells.Xu X., Croy J.T., Zeng W., Zhao L., Davignon I., Popov S., Yu K., Jiang H., Offermanns S.[...], Wilkie T.M.View abstractCategoriesFunction, SequencesSourceMGI: 95766PubMedEurope PMCJ Biol Chem 273:27275-27279 (1998)Mapped to11
Gonadotropin and gonadal steroid release in response to a gonadotropin- releasing hormone agonist in Gqalpha and G11alpha knockout mice.Stanislaus D., Janovick J.A., Ji T., Wilkie T.M., Offermanns S., Conn P.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95766PubMedEurope PMCEndocrinology 139:2710-2717 (1998)Mapped to6
G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.Williams C.J., Schultz R.M., Kopf G.S.View abstractCategorySequencesSourceMGI: 95766PubMedEurope PMCMol. Reprod. Dev. 44:315-323 (1996)Cited in111Mapped to99+
Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.Johnson G.J., Leis L.A., Dunlop P.C.View abstractCategorySequencesSourceMGI: 95766PubMedEurope PMCBiochem. J. 318:1023-1031 (1996)Cited in3Mapped to6
Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach.Rambhatla L., Patel B., Dhanasekaran N., Latham K.E.View abstractCategorySequencesSourceMGI: 95766PubMedEurope PMCMol Reprod Dev 41:314-324 (1995)Mapped to51
Galpha11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia.Ay B., Cyr S.M., Klovdahl K., Zhou W., Tognoni C.M., Iwasaki Y., Rhee E.P., Dedeoglu A., Simic P., Bastepe M.View abstractAnnotationGalpha11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia.CategoryFunctionSourceGeneRif: 14672PubMedEurope PMCJCI Insight 9:e178993-e178993 (2024)Mapped to7
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoryFunctionSourceMGI: 95766PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Stretch regulates alveologenesis and homeostasis via mesenchymal Galphaq/11-mediated TGFbeta2 activation.Goodwin A.T., John A.E., Joseph C., Habgood A., Tatler A.L., Susztak K., Palmer M., Offermanns S., Henderson N.C., Jenkins R.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95766PubMedEurope PMCDevelopment 150:dev201046-dev201046 (2023)Mapped to6
Deletion of Galphaq/11 or Galphas Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.Stamatiades G.A., Toufaily C., Kim H.K., Zhou X., Thompson I.R., Carroll R.S., Chen M., Weinstein L.S., Offermanns S.[...], Kaiser U.B.View abstractAnnotationDeletion of Galphaq/11 or Galphas Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 14672, MGI: 95766PubMedEurope PMCEndocrinology 163:bqab247-bqab247 (2022)Mapped to29
Gpisub>qpi/sub>alpha/Gpisub>11pi/sub>alpha deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.Wilson E.A., Sun H., Cui Z., Jahnke M.T., Pandey M., Metzger P., Gavrilova O., Chen M., Weinstein L.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95766PubMedEurope PMCAm J Physiol Endocrinol Metab 320:E270-E280 (2021)Mapped to25
The orphan receptor GPR139 signals via G<sub>q/11</sub> to oppose opioid effects.Stoveken H.M., Zucca S., Masuho I., Grill B., Martemyanov K.A.View abstractAnnotationThe orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.CategoryFunctionSourceGeneRif: 14672, MGI: 95766PubMedEurope PMCJ Biol Chem 295:10822-10830 (2020)Mapped to9
Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis.van den Bos E., Ambrosy B., Horsthemke M., Walbaum S., Bachg A.C., Wettschureck N., Innamorati G., Wilkie T.M., Hanley P.J.View abstractCategoryFunctionSourceMGI: 95766PubMedEurope PMCJ Biol Chem 295:7726-7742 (2020)Mapped to41
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.Wenzel J., Hansen C.E., Bettoni C., Vogt M.A., Lembrich B., Natsagdorj R., Huber G., Brands J., Schmidt K.[...], Schwaninger M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95766PubMedEurope PMCProc Natl Acad Sci U S A 117:1753-1761 (2020)Mapped to15
Helix 8 is the essential structural motif of mechanosensitive GPCRs.Erdogmus S., Storch U., Danner L., Becker J., Winter M., Ziegler N., Wirth A., Offermanns S., Hoffmann C.[...], Mederos Y Schnitzler M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95766PubMedEurope PMCNat Commun 10:5784-5784 (2019)Mapped to31
Myogenic vasoconstriction requires Gpisub>12pi/sub>/Gpisub>13pi/sub> and LARG to maintain local and systemic vascular resistance.Chennupati R., Wirth A., Favre J., Li R., Bonnavion R., Jin Y.J., Wietelmann A., Schweda F., Wettschureck N.[...], Offermanns S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95766PubMedEurope PMCElife 8:e49374-e49374 (2019)Mapped to20
NK2 receptor-mediated detrusor muscle contraction involves G<sub>q/11</sub>-dependent activation of voltage-dependent Ca<sup>2+</sup> channels and the RhoA-Rho kinase pathway.Der B., Molnar P.J., Ruisanchez E., Orsy P., Kerek M., Farago B., Nyirady P., Offermanns S., Benyo Z.View abstractCategoryFunctionSourceMGI: 95766PubMedEurope PMCAm J Physiol Renal Physiol 317:F1154-F1163 (2019)Mapped to6
Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.Sewell J., Kahn R.A.View abstractCategorySequencesSourceMGI: 95766PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 85:4620-4624 (1988)Cited in2Mapped to4
Uterine Galphapisub>q/11pi/sub> signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.de Oliveira V., Schaefer J., Calder M., Lydon J.P., DeMayo F.J., Bhattacharya M., Radovick S., Babwah A.V.View abstractCategoriesFunction, ExpressionSourceMGI: 95766PubMedEurope PMCFASEB J 33:9374-9387 (2019)Mapped to11
Skeletal Muscle-Specific Activation of G<sub>q</sub> Signaling Maintains Glucose Homeostasis.Bone D.B.J., Meister J., Knudsen J.R., Dattaroy D., Cohen A., Lee R., Lu H., Metzger D., Jensen T.E., Wess J.View abstractCategoryFunctionSourceMGI: 95766PubMedEurope PMCDiabetes 68:1341-1352 (2019)Mapped to6