MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8 E7 oncoprotein and EZH2.
Experiments on lymphocytic cell lines revealed that MAL protein-expressing T cells but not B cells are sensitive to Epsilon toxin (Etx) from Clostridium perfringens and reveal that the toxin may be used as a molecular tool to distinguish subpopulations of lymphocytes.
In high-grade serous ovarian carcinoma patients MAL was overexpressed in platinum-resistant compared to platinum-sensitive patients and resulted as an independent prognostic marker of survival.
This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas
Hypermethylation of the selected markers (MAL PRIMA1 PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women.
The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.
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