P21145 · MAL_HUMAN

  • Protein
    Myelin and lymphocyte protein
  • Gene
    MAL
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentendoplasmic reticulum
Cellular Componenthinge region between urothelial plaques of apical plasma membrane
Cellular Componentmembrane
Cellular Componentmembrane raft
Cellular Componentplasma membrane raft
Cellular ComponentSchmidt-Lanterman incisure
Molecular Functionlipid binding
Molecular Functionpeptidase activator activity involved in apoptotic process
Molecular Functionstructural constituent of myelin sheath
Biological Processapical protein localization
Biological Processapoptotic process
Biological Processcell differentiation
Biological Processcentral nervous system development
Biological Processcentral nervous system myelination
Biological Processmembrane raft polarization
Biological Processmyelination
Biological Processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Processprotein insertion into plasma membrane
Biological Processprotein localization to paranode region of axon

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Myelin and lymphocyte protein
  • Alternative names
    • T-lymphocyte maturation-associated protein

Gene names

    • Name
      MAL

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P21145
  • Secondary accessions
    • Q6FH77

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-24Cytoplasmic
Transmembrane25-46Helical
Topological domain47-53Extracellular
Transmembrane54-75Helical
Topological domain76-92Cytoplasmic
Transmembrane93-114Helical
Topological domain115-125Extracellular
Transmembrane126-147Helical
Topological domain148-153Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 180 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001568051-153Myelin and lymphocyte protein

Post-translational modification

Lipoprotein.

Keywords

Proteomic databases

Expression

Developmental stage

Expressed in the intermediate and late stages of T-cell differentiation.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P21145AMHR2 Q166713EBI-3932027, EBI-6423788
BINARY P21145AQP6 Q135203EBI-3932027, EBI-13059134
BINARY P21145BCL2L13 Q9BXK55EBI-3932027, EBI-747430
BINARY P21145BTK Q061875EBI-3932027, EBI-624835
BINARY P21145BTN2A1 Q7KYR7-43EBI-3932027, EBI-17841208
BINARY P21145CALN1 Q9BXU93EBI-3932027, EBI-12187137
BINARY P21145CD300LG Q6UXG33EBI-3932027, EBI-10254587
BINARY P21145CD3G P096933EBI-3932027, EBI-3862428
BINARY P21145CD40 P259423EBI-3932027, EBI-525714
BINARY P21145CD53 P193973EBI-3932027, EBI-6657396
BINARY P21145CD69 Q071083EBI-3932027, EBI-2836595
BINARY P21145CLDN14 O955003EBI-3932027, EBI-11742599
BINARY P21145CLDN20 P568803EBI-3932027, EBI-23801559
BINARY P21145CLDN7 O954713EBI-3932027, EBI-740744
BINARY P21145CLDN9 O954843EBI-3932027, EBI-18341636
BINARY P21145CLEC4C Q8WTT04EBI-3932027, EBI-12913226
BINARY P21145CLSTN3 Q9BQT93EBI-3932027, EBI-11291074
BINARY P21145CPLX4 Q7Z7G23EBI-3932027, EBI-18013275
BINARY P21145CREB3L1 Q96BA83EBI-3932027, EBI-6942903
BINARY P21145CXADR P783103EBI-3932027, EBI-747931
BINARY P21145DAGLA Q9Y4D23EBI-3932027, EBI-12808806
BINARY P21145EDA Q928387EBI-3932027, EBI-529425
BINARY P21145EMP1 P548493EBI-3932027, EBI-4319440
BINARY P21145EVI2A P227943EBI-3932027, EBI-2870359
BINARY P21145FAM209A Q5JX713EBI-3932027, EBI-18304435
BINARY P21145FCRL2 Q96LA5-23EBI-3932027, EBI-17263163
BINARY P21145FIBCD1 Q8N5396EBI-3932027, EBI-10200808
BINARY P21145FNDC9 Q8TBE33EBI-3932027, EBI-12142257
BINARY P21145GJA8 P481653EBI-3932027, EBI-17458373
BINARY P21145GJB1 P080343EBI-3932027, EBI-17565645
BINARY P21145GPR152 Q8TDT23EBI-3932027, EBI-13345167
BINARY P21145GRAMD1A Q96CP63EBI-3932027, EBI-1384139
BINARY P21145GSG1L Q6UXU4-23EBI-3932027, EBI-18632127
BINARY P21145HIBADH P319373EBI-3932027, EBI-11427100
BINARY P21145IL10RA Q136513EBI-3932027, EBI-1031656
BINARY P21145IL20RB Q6UXL03EBI-3932027, EBI-14022792
BINARY P21145JAML Q86YT9-23EBI-3932027, EBI-17244059
BINARY P21145KCNA1 Q094703EBI-3932027, EBI-8286599
BINARY P21145KCNA10 Q163223EBI-3932027, EBI-12265328
BINARY P21145KCNMB4 Q86W473EBI-3932027, EBI-19112227
BINARY P21145KLRC1 P267156EBI-3932027, EBI-9018187
BINARY P21145LDLRAD1 Q5T7007EBI-3932027, EBI-10173166
BINARY P21145LMAN2L Q9H0V93EBI-3932027, EBI-9091707
BINARY P21145LRRC25 Q8N3863EBI-3932027, EBI-11304917
BINARY P21145LRTM1 Q9HBL63EBI-3932027, EBI-12825005
BINARY P21145LSMEM1 Q8N8F73EBI-3932027, EBI-10200825
BINARY P21145MS4A4A Q96JQ53EBI-3932027, EBI-12820341
BINARY P21145NCAPH2 Q6IBW4-43EBI-3932027, EBI-10247000
BINARY P21145NKAIN4 Q8IVV83EBI-3932027, EBI-17791123
BINARY P21145NPDC1 Q9NQX53EBI-3932027, EBI-748927
BINARY P21145OPRM1 P35372-103EBI-3932027, EBI-12807478
BINARY P21145PERP Q96FX83EBI-3932027, EBI-17183069
BINARY P21145PLA2G10 O154963EBI-3932027, EBI-726466
BINARY P21145PRRT1 Q99946-23EBI-3932027, EBI-12211089
BINARY P21145PTPRN Q16849-33EBI-3932027, EBI-10200782
BINARY P21145RAMP1 O608943EBI-3932027, EBI-962893
BINARY P21145SDC4 P314313EBI-3932027, EBI-3913237
BINARY P21145SGCB Q165853EBI-3932027, EBI-5663627
BINARY P21145SHISA3 A0PJX43EBI-3932027, EBI-10171518
BINARY P21145SHISA4 Q96DD73EBI-3932027, EBI-18035902
BINARY P21145SLC10A1 Q149733EBI-3932027, EBI-3923031
BINARY P21145SLC35C2 Q9NQQ7-33EBI-3932027, EBI-17295964
BINARY P21145SMIM3 Q9BZL36EBI-3932027, EBI-741850
BINARY P21145SPINT1 O43278-23EBI-3932027, EBI-12078338
BINARY P21145STX1A Q166234EBI-3932027, EBI-712466
BINARY P21145SYNDIG1 Q9H7V23EBI-3932027, EBI-726331
BINARY P21145TEX29 Q8N6K03EBI-3932027, EBI-19027521
BINARY P21145TIGIT Q495A13EBI-3932027, EBI-4314807
BINARY P21145TM4SF18 Q96CE83EBI-3932027, EBI-13351685
BINARY P21145TMEM106C Q9BVX23EBI-3932027, EBI-2821497
BINARY P21145TMEM174 Q8WUU83EBI-3932027, EBI-10276729
BINARY P21145TMEM207 Q6UWW93EBI-3932027, EBI-13301303
BINARY P21145TMEM248 Q9NWD83EBI-3932027, EBI-10314986
BINARY P21145TMEM30A Q9NV96-23EBI-3932027, EBI-12921610
BINARY P21145TMEM52B Q4KMG93EBI-3932027, EBI-18178701
BINARY P21145TNFSF14 O435575EBI-3932027, EBI-524131
BINARY P21145TSPO2 Q5TGU03EBI-3932027, EBI-12195249
BINARY P21145USP7 Q930093EBI-3932027, EBI-302474

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-151MARVEL

Sequence similarities

Belongs to the MAL family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

P21145-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    153
  • Mass (Da)
    16,714
  • Last updated
    1991-05-01 v1
  • Checksum
    F821FC1C0ADBE775
MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHGGETSWVTLDAAYHCTAALFYLSASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS

P21145-2

  • Name
    B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P21145-3

  • Name
    C
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P21145-4

  • Name
    D
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_00316332-87in isoform C
Alternative sequenceVSP_00316232-129in isoform D
Alternative sequenceVSP_00316488-129in isoform B

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M15800
EMBL· GenBank· DDBJ
AAA36196.1
EMBL· GenBank· DDBJ
mRNA
X76678
EMBL· GenBank· DDBJ
CAA54100.1
EMBL· GenBank· DDBJ
mRNA
X76679
EMBL· GenBank· DDBJ
CAA54101.1
EMBL· GenBank· DDBJ
mRNA
X76680
EMBL· GenBank· DDBJ
CAA54102.1
EMBL· GenBank· DDBJ
mRNA
X76681
EMBL· GenBank· DDBJ
CAA54103.1
EMBL· GenBank· DDBJ
mRNA
X76220
EMBL· GenBank· DDBJ
CAA53809.1
EMBL· GenBank· DDBJ
Genomic DNA
X76221
EMBL· GenBank· DDBJ
CAA53809.1
EMBL· GenBank· DDBJ
Genomic DNA
X76222
EMBL· GenBank· DDBJ
CAA53809.1
EMBL· GenBank· DDBJ
Genomic DNA
X76223
EMBL· GenBank· DDBJ
CAA53809.1
EMBL· GenBank· DDBJ
Genomic DNA
AK311844
EMBL· GenBank· DDBJ
BAG34786.1
EMBL· GenBank· DDBJ
mRNA
CR541879
EMBL· GenBank· DDBJ
CAG46677.1
EMBL· GenBank· DDBJ
mRNA
AC103563
EMBL· GenBank· DDBJ
AAY24121.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471219
EMBL· GenBank· DDBJ
EAX10705.1
EMBL· GenBank· DDBJ
Genomic DNA
BC000458
EMBL· GenBank· DDBJ
AAH00458.1
EMBL· GenBank· DDBJ
mRNA
BC003006
EMBL· GenBank· DDBJ
AAH03006.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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