P20807 · CAN3_HUMAN
- ProteinCalpain-3
- GeneCAPN3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids821 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Activity regulation
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 129 | |||||
Sequence: C | ||||||
Active site | 334 | |||||
Sequence: H | ||||||
Active site | 358 | |||||
Sequence: N | ||||||
Binding site | 662 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 665 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 667 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 672 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 705 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 707 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 709 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 711 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 716 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 735 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 737 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 739 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 741 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 746 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 800 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 802 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 804 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 806 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: I |
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCalpain-3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP20807
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 1 (LGMDR1)
- Note
- DescriptionAn autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. The symptoms usually begin during the first two decades of life, and the disease gradually worsens, often resulting in loss of walking ability 10 or 20 years after onset.
- See alsoMIM:253600
Natural variants in LGMDR1
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_009548 | 4 | V>I | in LGMDR1; dbSNP:rs140660066 | |
VAR_009549 | 26 | P>L | in LGMDR1; dbSNP:rs762020512 | |
VAR_009550 | 77 | D>N | in LGMDR1; dbSNP:rs2141102703 | |
VAR_009551 | 86 | S>F | in LGMDR1; severe; dbSNP:rs121434546 | |
VAR_009552 | 93-100 | missing | in LGMDR1 | |
VAR_009554 | 118 | R>G | in LGMDR1; dbSNP:rs1566973583 | |
VAR_009555 | 137 | C>R | in LGMDR1 | |
VAR_009556 | 162 | I>L | in LGMDR1 | |
VAR_001363 | 182 | L>Q | in LGMDR1; dbSNP:rs2141164715 | |
VAR_009557 | 183 | P>L | in LGMDR1 | |
VAR_009559 | 189 | L>P | in LGMDR1; dbSNP:rs758795961 | |
VAR_001364 | 200-204 | missing | in LGMDR1 | |
VAR_009560 | 214 | G>S | in LGMDR1; dbSNP:rs369784333 | |
VAR_009561 | 215 | S>P | in LGMDR1; dbSNP:rs2053478068 | |
VAR_009562 | 215-221 | missing | in LGMDR1 and LGMDD4 | |
VAR_009563 | 217 | E>K | in LGMDR1; dbSNP:rs773001194 | |
VAR_009564 | 222 | G>R | in LGMDR1; dbSNP:rs1345121557 | |
VAR_009565 | 226 | E>K | in LGMDR1 | |
VAR_009566 | 232 | T>I | in LGMDR1 | |
VAR_001365 | 234 | G>E | in LGMDR1; dbSNP:rs1555420634 | |
VAR_009568 | 254 | missing | in LGMDR1 | |
VAR_076561 | 266-267 | missing | in LGMDR1 | |
VAR_009569 | 319 | P>L | in LGMDR1; dbSNP:rs121434547 | |
VAR_009570 | 334 | H>Q | in LGMDR1; dbSNP:rs374833797 | |
VAR_009571 | 336 | Y>N | in LGMDR1 | |
VAR_001366 | 354 | V>G | in LGMDR1; dbSNP:rs1555421271 | |
VAR_009572 | 360 | W>C | in LGMDR1; dbSNP:rs267606703 | |
VAR_009573 | 437 | R>C | in LGMDR1; dbSNP:rs777483913 | |
VAR_009574 | 440 | R>W | in LGMDR1; dbSNP:rs777323132 | |
VAR_009575 | 441 | G>D | in LGMDR1 | |
VAR_009576 | 445 | G>R | in LGMDR1; dbSNP:rs773827877 | |
VAR_009577 | 448 | R>C | in LGMDR1; dbSNP:rs776043976 | |
VAR_009578 | 448 | R>G | in LGMDR1; dbSNP:rs776043976 | |
VAR_009579 | 448 | R>H | in LGMDR1; dbSNP:rs863224956 | |
VAR_009580 | 479 | S>G | in LGMDR1; dbSNP:rs201736037 | |
VAR_009581 | 486 | Q>E | in LGMDR1 | |
VAR_009582 | 489 | R>Q | in LGMDR1; dbSNP:rs147764579 | |
VAR_009583 | 489 | R>W | in LGMDR1; dbSNP:rs863224957 | |
VAR_009584 | 490 | R>Q | in LGMDR1; dbSNP:rs121434548 | |
VAR_001367 | 490 | R>W | in LGMDR1; dbSNP:rs141656719 | |
VAR_009585 | 493 | R>W | in LGMDR1; dbSNP:rs557164942 | |
VAR_009586 | 496 | G>R | in LGMDR1; dbSNP:rs761637940 | |
VAR_009587 | 502 | I>T | in LGMDR1; dbSNP:rs148044781 | |
VAR_009588 | 541 | R>Q | in LGMDR1; dbSNP:rs398123143 | |
VAR_009589 | 567 | G>W | in LGMDR1; dbSNP:rs727503839 | |
VAR_001368 | 572 | R>Q | in LGMDR1; dbSNP:rs121434544 | |
VAR_009590 | 572 | R>W | in LGMDR1; dbSNP:rs863224959 | |
VAR_009591 | 606 | S>L | in LGMDR1; dbSNP:rs199806879 | |
VAR_009592 | 638 | Q>P | in LGMDR1 | |
VAR_009593 | 698 | R>P | in LGMDR1 | |
VAR_009594 | 702 | A>V | in LGMDR1; dbSNP:rs886042557 | |
VAR_009595 | 705 | D>G | in LGMDR1 | |
VAR_009596 | 705 | D>H | in LGMDR1 | |
VAR_009597 | 731 | F>S | in LGMDR1 | |
VAR_001369 | 744 | S>G | in LGMDR1; dbSNP:rs750083132 | |
VAR_009598 | 748 | R>Q | in LGMDR1; dbSNP:rs587780290 | |
VAR_001370 | 769 | R>Q | in LGMDR1; dbSNP:rs80338802 | |
VAR_009599 | 774 | H>D | in LGMDR1; uncertain significance | |
VAR_009600 | 798 | A>E | in LGMDR1; uncertain significance; dbSNP:rs149095128 |
Muscular dystrophy, limb-girdle, autosomal dominant 4 (LGMDD4)
- Note
- DescriptionA form of autosomal dominant limb-girdle muscular dystrophy, a myopathy characterized by proximal and/or distal muscle weakness and atrophy. The age at onset is variable and can range from the first to the sixth decade, although later onset is less common. LGMDD4 is characterized by onset of proximal muscle weakness in young adulthood, gait difficulties, increased serum creatine kinase, myalgia, and back pain. Some patients may have upper limb involvement. Disease severity and expressivity are highly variable.
- See alsoMIM:618129
Natural variants in LGMDD4
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_009562 | 215-221 | missing | in LGMDR1 and LGMDD4 |
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_009548 | 4 | in LGMDR1; dbSNP:rs140660066 | |||
Sequence: V → I | ||||||
Natural variant | VAR_022272 | 21 | in dbSNP:rs28364364 | |||
Sequence: G → E | ||||||
Natural variant | VAR_009549 | 26 | in LGMDR1; dbSNP:rs762020512 | |||
Sequence: P → L | ||||||
Natural variant | VAR_009550 | 77 | in LGMDR1; dbSNP:rs2141102703 | |||
Sequence: D → N | ||||||
Natural variant | VAR_009551 | 86 | in LGMDR1; severe; dbSNP:rs121434546 | |||
Sequence: S → F | ||||||
Natural variant | VAR_009552 | 93-100 | in LGMDR1 | |||
Sequence: Missing | ||||||
Natural variant | VAR_009553 | 107 | in dbSNP:rs1801505 | |||
Sequence: E → K | ||||||
Natural variant | VAR_009554 | 118 | in LGMDR1; dbSNP:rs1566973583 | |||
Sequence: R → G | ||||||
Mutagenesis | 129 | Loss of activity. No effect on CMYA5-binding. Does not degradate p53/TP53. | ||||
Sequence: C → S | ||||||
Natural variant | VAR_009555 | 137 | in LGMDR1 | |||
Sequence: C → R | ||||||
Natural variant | VAR_015389 | 160 | in dbSNP:rs17592 | |||
Sequence: A → G | ||||||
Natural variant | VAR_009556 | 162 | in LGMDR1 | |||
Sequence: I → L | ||||||
Natural variant | VAR_001363 | 182 | in LGMDR1; dbSNP:rs2141164715 | |||
Sequence: L → Q | ||||||
Natural variant | VAR_009557 | 183 | in LGMDR1 | |||
Sequence: P → L | ||||||
Natural variant | VAR_009558 | 184 | in dbSNP:rs35889956 | |||
Sequence: T → M | ||||||
Natural variant | VAR_009559 | 189 | in LGMDR1; dbSNP:rs758795961 | |||
Sequence: L → P | ||||||
Natural variant | VAR_001364 | 200-204 | in LGMDR1 | |||
Sequence: Missing | ||||||
Natural variant | VAR_009560 | 214 | in LGMDR1; dbSNP:rs369784333 | |||
Sequence: G → S | ||||||
Natural variant | VAR_009561 | 215 | in LGMDR1; dbSNP:rs2053478068 | |||
Sequence: S → P | ||||||
Natural variant | VAR_009562 | 215-221 | in LGMDR1 and LGMDD4 | |||
Sequence: Missing | ||||||
Natural variant | VAR_009563 | 217 | in LGMDR1; dbSNP:rs773001194 | |||
Sequence: E → K | ||||||
Natural variant | VAR_009564 | 222 | in LGMDR1; dbSNP:rs1345121557 | |||
Sequence: G → R | ||||||
Natural variant | VAR_009565 | 226 | in LGMDR1 | |||
Sequence: E → K | ||||||
Natural variant | VAR_009566 | 232 | in LGMDR1 | |||
Sequence: T → I | ||||||
Natural variant | VAR_001365 | 234 | in LGMDR1; dbSNP:rs1555420634 | |||
Sequence: G → E | ||||||
Natural variant | VAR_009567 | 236 | in dbSNP:rs1801449 | |||
Sequence: A → T | ||||||
Natural variant | VAR_009568 | 254 | in LGMDR1 | |||
Sequence: Missing | ||||||
Natural variant | VAR_076561 | 266-267 | in LGMDR1 | |||
Sequence: Missing | ||||||
Natural variant | VAR_009569 | 319 | in LGMDR1; dbSNP:rs121434547 | |||
Sequence: P → L | ||||||
Natural variant | VAR_009570 | 334 | in LGMDR1; dbSNP:rs374833797 | |||
Sequence: H → Q | ||||||
Natural variant | VAR_009571 | 336 | in LGMDR1 | |||
Sequence: Y → N | ||||||
Natural variant | VAR_001366 | 354 | in LGMDR1; dbSNP:rs1555421271 | |||
Sequence: V → G | ||||||
Natural variant | VAR_009572 | 360 | in LGMDR1; dbSNP:rs267606703 | |||
Sequence: W → C | ||||||
Natural variant | VAR_009573 | 437 | in LGMDR1; dbSNP:rs777483913 | |||
Sequence: R → C | ||||||
Natural variant | VAR_009574 | 440 | in LGMDR1; dbSNP:rs777323132 | |||
Sequence: R → W | ||||||
Natural variant | VAR_009575 | 441 | in LGMDR1 | |||
Sequence: G → D | ||||||
Natural variant | VAR_009576 | 445 | in LGMDR1; dbSNP:rs773827877 | |||
Sequence: G → R | ||||||
Natural variant | VAR_009577 | 448 | in LGMDR1; dbSNP:rs776043976 | |||
Sequence: R → C | ||||||
Natural variant | VAR_009578 | 448 | in LGMDR1; dbSNP:rs776043976 | |||
Sequence: R → G | ||||||
Natural variant | VAR_009579 | 448 | in LGMDR1; dbSNP:rs863224956 | |||
Sequence: R → H | ||||||
Natural variant | VAR_009580 | 479 | in LGMDR1; dbSNP:rs201736037 | |||
Sequence: S → G | ||||||
Natural variant | VAR_009581 | 486 | in LGMDR1 | |||
Sequence: Q → E | ||||||
Natural variant | VAR_009582 | 489 | in LGMDR1; dbSNP:rs147764579 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_009583 | 489 | in LGMDR1; dbSNP:rs863224957 | |||
Sequence: R → W | ||||||
Natural variant | VAR_009584 | 490 | in LGMDR1; dbSNP:rs121434548 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_001367 | 490 | in LGMDR1; dbSNP:rs141656719 | |||
Sequence: R → W | ||||||
Natural variant | VAR_009585 | 493 | in LGMDR1; dbSNP:rs557164942 | |||
Sequence: R → W | ||||||
Natural variant | VAR_009586 | 496 | in LGMDR1; dbSNP:rs761637940 | |||
Sequence: G → R | ||||||
Natural variant | VAR_009587 | 502 | in LGMDR1; dbSNP:rs148044781 | |||
Sequence: I → T | ||||||
Natural variant | VAR_009588 | 541 | in LGMDR1; dbSNP:rs398123143 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_009589 | 567 | in LGMDR1; dbSNP:rs727503839 | |||
Sequence: G → W | ||||||
Natural variant | VAR_001368 | 572 | in LGMDR1; dbSNP:rs121434544 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_009590 | 572 | in LGMDR1; dbSNP:rs863224959 | |||
Sequence: R → W | ||||||
Natural variant | VAR_009591 | 606 | in LGMDR1; dbSNP:rs199806879 | |||
Sequence: S → L | ||||||
Natural variant | VAR_047691 | 622 | in dbSNP:rs11557723 | |||
Sequence: E → A | ||||||
Natural variant | VAR_009592 | 638 | in LGMDR1 | |||
Sequence: Q → P | ||||||
Natural variant | VAR_009593 | 698 | in LGMDR1 | |||
Sequence: R → P | ||||||
Natural variant | VAR_009594 | 702 | in LGMDR1; dbSNP:rs886042557 | |||
Sequence: A → V | ||||||
Natural variant | VAR_009595 | 705 | in LGMDR1 | |||
Sequence: D → G | ||||||
Natural variant | VAR_009596 | 705 | in LGMDR1 | |||
Sequence: D → H | ||||||
Natural variant | VAR_009597 | 731 | in LGMDR1 | |||
Sequence: F → S | ||||||
Natural variant | VAR_001369 | 744 | in LGMDR1; dbSNP:rs750083132 | |||
Sequence: S → G | ||||||
Natural variant | VAR_009598 | 748 | in LGMDR1; dbSNP:rs587780290 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_001370 | 769 | in LGMDR1; dbSNP:rs80338802 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_009599 | 774 | in LGMDR1; uncertain significance | |||
Sequence: H → D | ||||||
Natural variant | VAR_009600 | 798 | in LGMDR1; uncertain significance; dbSNP:rs149095128 | |||
Sequence: A → E |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,248 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000207706 | 1-821 | UniProt | Calpain-3 | |||
Sequence: MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA | |||||||
Modified residue (large scale data) | 19 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 621 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with TTN/titin (PubMed:14583192).
Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis (PubMed:20634290).
Interacts with SIMC1 (PubMed:23707407).
Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus (PubMed:23357851, PubMed:27657329).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 7-37 | Disordered | ||||
Sequence: ASVAPRTAAEPRSPGPVPHPAQSKATEAGGG | ||||||
Domain | 74-417 | Calpain catalytic | ||||
Sequence: LYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLT | ||||||
Region | 418-586 | Domain III | ||||
Sequence: ADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVEN | ||||||
Region | 587-649 | Linker | ||||
Sequence: TISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE | ||||||
Region | 609-652 | Disordered | ||||
Sequence: ANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQ | ||||||
Compositional bias | 613-630 | Basic and acidic residues | ||||
Sequence: KELGVDQESEEGKGKTSP | ||||||
Compositional bias | 631-652 | Polar residues | ||||
Sequence: DKQKQSPQPQPGSSDQESEEQQ | ||||||
Domain | 649-683 | EF-hand 1 | ||||
Sequence: EEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNK | ||||||
Region | 650-821 | Domain IV | ||||
Sequence: EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA | ||||||
Domain | 692-725 | EF-hand 2 | ||||
Sequence: FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK | ||||||
Domain | 722-757 | EF-hand 3 | ||||
Sequence: NKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFH | ||||||
Domain | 787-821 | EF-hand 4 | ||||
Sequence: VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
P20807-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameI
- Length821
- Mass (Da)94,254
- Last updated1996-02-01 v2
- ChecksumBC608E8B67AA2741
P20807-2
- NameII
P20807-3
- NameIII
- Differences from canonical
- 595-600: Missing
P20807-4
- NameIV
- Differences from canonical
- 1-512: Missing
P20807-5
- NameV
- Differences from canonical
- 1-665: Missing
Computationally mapped potential isoform sequences
There are 20 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0S2Z3E6 | A0A0S2Z3E6_HUMAN | CAPN3 | 83 | ||
H3BUR3 | H3BUR3_HUMAN | CAPN3 | 110 | ||
H3BV08 | H3BV08_HUMAN | CAPN3 | 169 | ||
H3BUZ3 | H3BUZ3_HUMAN | CAPN3 | 157 | ||
H3BS30 | H3BS30_HUMAN | CAPN3 | 84 | ||
H3BSA2 | H3BSA2_HUMAN | CAPN3 | 188 | ||
H3BS77 | H3BS77_HUMAN | CAPN3 | 191 | ||
H3BNN7 | H3BNN7_HUMAN | CAPN3 | 110 | ||
H3BMH1 | H3BMH1_HUMAN | CAPN3 | 255 | ||
F8W8F5 | F8W8F5_HUMAN | CAPN3 | 773 | ||
A0A669KBE1 | A0A669KBE1_HUMAN | CAPN3 | 99 | ||
A0A669KBA3 | A0A669KBA3_HUMAN | CAPN3 | 201 | ||
A0A669KAX6 | A0A669KAX6_HUMAN | CAPN3 | 122 | ||
A0A669KB98 | A0A669KB98_HUMAN | CAPN3 | 144 | ||
A0A669KAU4 | A0A669KAU4_HUMAN | CAPN3 | 43 | ||
A0A669KAU6 | A0A669KAU6_HUMAN | CAPN3 | 184 | ||
A0A669KB02 | A0A669KB02_HUMAN | CAPN3 | 84 | ||
A0A669KB08 | A0A669KB08_HUMAN | CAPN3 | 229 | ||
A0A669KB11 | A0A669KB11_HUMAN | CAPN3 | 109 | ||
A0A669KAB9 | A0A669KAB9_HUMAN | CAPN3 | 202 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_007813 | 1-512 | in isoform IV | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_044255 | 1-665 | in isoform V | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_005227 | 268-315 | in isoform II | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_005229 | 595-600 | in isoform III | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_005228 | 595-638 | in isoform II | |||
Sequence: Missing | ||||||
Compositional bias | 613-630 | Basic and acidic residues | ||||
Sequence: KELGVDQESEEGKGKTSP | ||||||
Compositional bias | 631-652 | Polar residues | ||||
Sequence: DKQKQSPQPQPGSSDQESEEQQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X85030 EMBL· GenBank· DDBJ | CAA59403.1 EMBL· GenBank· DDBJ | mRNA | ||
AF209502 EMBL· GenBank· DDBJ | AAL40183.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF127764 EMBL· GenBank· DDBJ | AAD28253.1 EMBL· GenBank· DDBJ | mRNA | ||
AF127765 EMBL· GenBank· DDBJ | AAD28254.3 EMBL· GenBank· DDBJ | mRNA | ||
BT007322 EMBL· GenBank· DDBJ | AAP35986.1 EMBL· GenBank· DDBJ | mRNA | ||
AY902237 EMBL· GenBank· DDBJ | AAW69391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC012651 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC003169 EMBL· GenBank· DDBJ | AAH03169.1 EMBL· GenBank· DDBJ | mRNA | ||
BC003521 EMBL· GenBank· DDBJ | AAH03521.1 EMBL· GenBank· DDBJ | mRNA | ||
BC004883 EMBL· GenBank· DDBJ | AAH04883.1 EMBL· GenBank· DDBJ | mRNA | ||
BC007810 EMBL· GenBank· DDBJ | AAH07810.3 EMBL· GenBank· DDBJ | mRNA | ||
BC067126 EMBL· GenBank· DDBJ | AAH67126.1 EMBL· GenBank· DDBJ | mRNA | ||
BC100782 EMBL· GenBank· DDBJ | AAI00783.1 EMBL· GenBank· DDBJ | mRNA | ||
BC107791 EMBL· GenBank· DDBJ | AAI07792.1 EMBL· GenBank· DDBJ | mRNA | ||
BC128605 EMBL· GenBank· DDBJ | AAI28606.1 EMBL· GenBank· DDBJ | mRNA | ||
BC146649 EMBL· GenBank· DDBJ | AAI46650.1 EMBL· GenBank· DDBJ | mRNA | ||
BC146672 EMBL· GenBank· DDBJ | AAI46673.1 EMBL· GenBank· DDBJ | mRNA |