P20789 · NTR1_RAT

  • Protein
    Neurotensin receptor type 1
  • Gene
    Ntsr1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105).
Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentaxon terminus
Cellular Componentcell surface
Cellular Componentcytoplasmic side of plasma membrane
Cellular Componentdendrite
Cellular Componentdendritic shaft
Cellular Componentdendritic spine
Cellular Componentmembrane raft
Cellular Componentneuron spine
Cellular Componentneuronal cell body
Cellular Componentperikaryon
Cellular Componentplasma membrane
Cellular Componentsymmetric synapse
Cellular Componentterminal bouton
Molecular FunctionG protein-coupled neurotensin receptor activity
Molecular Functionidentical protein binding
Molecular Functionprotein-containing complex binding
Biological Processadult locomotory behavior
Biological ProcessD-aspartate import across plasma membrane
Biological Processdetection of temperature stimulus involved in sensory perception of pain
Biological Processinositol phosphate catabolic process
Biological ProcessL-glutamate import across plasma membrane
Biological Processlearning
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of release of sequestered calcium ion into cytosol
Biological Processnegative regulation of systemic arterial blood pressure
Biological Processneuropeptide signaling pathway
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of arachidonic acid secretion
Biological Processpositive regulation of gamma-aminobutyric acid secretion
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of glutamate secretion
Biological Processpositive regulation of inhibitory postsynaptic potential
Biological Processpositive regulation of inositol phosphate biosynthetic process
Biological Processpositive regulation of release of sequestered calcium ion into cytosol
Biological Processregulation of membrane depolarization
Biological Processregulation of respiratory gaseous exchange
Biological Processresponse to lipid
Biological Processtemperature homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neurotensin receptor type 1
  • Short names
    NT-R-1; NTR1
  • Alternative names
    • High-affinity levocabastine-insensitive neurotensin receptor
    • NTRH

Gene names

    • Name
      Ntsr1
    • Synonyms
      Ntsr

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P20789

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-68Extracellular
Transmembrane69-89Helical; Name=1
Topological domain90-103Cytoplasmic
Transmembrane104-123Helical; Name=2
Topological domain124-143Extracellular
Transmembrane144-165Helical; Name=3
Topological domain166-185Cytoplasmic
Transmembrane186-206Helical; Name=4
Topological domain207-235Extracellular
Transmembrane236-260Helical; Name=5
Topological domain261-308Cytoplasmic
Transmembrane309-330Helical; Name=6
Topological domain331-348Extracellular
Transmembrane349-369Helical; Name=7
Topological domain370-424Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis166Abolishes signaling via G-proteins; when associated with A-310 and A-358.
Mutagenesis310Abolishes signaling via G-proteins; when associated with A-166 and A-358.
Mutagenesis358Abolishes signaling via G-proteins; when associated with A-166 and A-310.

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, lipidation.

TypeIDPosition(s)Description
ChainPRO_00000699481-424Neurotensin receptor type 1
Glycosylation4N-linked (GlcNAc...) asparagine
Glycosylation38N-linked (GlcNAc...) asparagine
Glycosylation42N-linked (GlcNAc...) asparagine
Disulfide bond142↔225
Lipidation386S-palmitoyl cysteine
Lipidation388S-palmitoyl cysteine

Post-translational modification

N-glycosylated.
Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in brain and small intestine.

Gene expression databases

Interaction

Subunit

Interacts (palmitoylated form) with GNA11.

Protein-protein interaction databases

Chemistry

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-23Disordered
Region326-349Neurotensin binding
Region397-424Disordered
Compositional bias403-424Polar residues

Domain

The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    47,055
  • Last updated
    1991-02-01 v1
  • Checksum
    A9C2F7EAF8D9BCD3
MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATRETLY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias403-424Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp