P20645 · MPRD_HUMAN

  • Protein
    Cation-dependent mannose-6-phosphate receptor
  • Gene
    M6PR
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentclathrin-coated endocytic vesicle membrane
Cellular Componentendosome
Cellular Componentlate endosome
Cellular Componentlysosomal membrane
Cellular Componentmembrane
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componenttrans-Golgi network
Cellular Componenttrans-Golgi network membrane
Cellular Componenttransport vesicle
Molecular Functionprotein domain specific binding
Molecular Functionprotein transporter activity
Molecular Functionretromer complex binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processendosome to lysosome transport
Biological Processglycosphingolipid catabolic process
Biological Processlysosomal transport
Biological Processprotein targeting to lysosome
Biological Processreceptor-mediated endocytosis
Biological Processsecretion of lysosomal enzymes

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Cation-dependent mannose-6-phosphate receptor
  • Short names
    CD Man-6-P receptor; CD-MPR
  • Alternative names
    • 46 kDa mannose 6-phosphate receptor (MPR 46)

Gene names

    • Name
      M6PR
    • Synonyms
      MPR46, MPRD

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P20645
  • Secondary accessions
    • A8K528
    • D3DUV5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain27-185Lumenal
Transmembrane186-210Helical
Topological domain211-277Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 259 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Signal1-26UniProt
ChainPRO_000001922627-277UniProtCation-dependent mannose-6-phosphate receptor
Disulfide bond32↔78UniProt
Glycosylation57UniProtN-linked (GlcNAc...) asparagine
Glycosylation83UniProtN-linked (GlcNAc...) asparagine
Glycosylation94UniProtN-linked (GlcNAc...) asparagine
Glycosylation107UniProtN-linked (GlcNAc...) asparagine
Glycosylation113UniProtN-linked (GlcNAc...) asparagine
Disulfide bond132↔167UniProt
Disulfide bond145↔179UniProt
Modified residue267UniProtPhosphoserine
Modified residue (large scale data)267PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer. Binds GGA1, GGA2 and GGA3.

Binary interactions

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain30-181MRH
Region256-277Disordered

Domain

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    277
  • Mass (Da)
    30,993
  • Last updated
    1991-02-01 v1
  • Checksum
    1093FE25DEB6C8E8
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM

Computationally mapped potential isoform sequences

There are 10 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YGE9H0YGE9_HUMANM6PR104
H0YGT2H0YGT2_HUMANM6PR122
H0YFY9H0YFY9_HUMANM6PR85
H0YFL0H0YFL0_HUMANM6PR96
H0YF90H0YF90_HUMANM6PR148
F5GXE0F5GXE0_HUMANM6PR92
F5GX30F5GX30_HUMANM6PR191
F5GXU0F5GXU0_HUMANM6PR109
F5H883F5H883_HUMANM6PR133
F5H4U1F5H4U1_HUMANM6PR25

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M16985
EMBL· GenBank· DDBJ
AAA59542.1
EMBL· GenBank· DDBJ
mRNA
X56254
EMBL· GenBank· DDBJ
CAB94715.1
EMBL· GenBank· DDBJ
Genomic DNA
X56255
EMBL· GenBank· DDBJ
CAB94715.1
EMBL· GenBank· DDBJ
Genomic DNA
X56256
EMBL· GenBank· DDBJ
CAB94715.1
EMBL· GenBank· DDBJ
Genomic DNA
X56257
EMBL· GenBank· DDBJ
CAB94715.1
EMBL· GenBank· DDBJ
Genomic DNA
AK291143
EMBL· GenBank· DDBJ
BAF83832.1
EMBL· GenBank· DDBJ
mRNA
CH471116
EMBL· GenBank· DDBJ
EAW88596.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471116
EMBL· GenBank· DDBJ
EAW88597.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471116
EMBL· GenBank· DDBJ
EAW88598.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471116
EMBL· GenBank· DDBJ
EAW88599.1
EMBL· GenBank· DDBJ
Genomic DNA
BC024206
EMBL· GenBank· DDBJ
AAH24206.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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