P20645 · MPRD_HUMAN
- ProteinCation-dependent mannose-6-phosphate receptor
- GeneM6PR
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids277 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Miscellaneous
This receptor has optimal binding in the presence of divalent cations.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | clathrin-coated endocytic vesicle membrane | |
Cellular Component | endosome | |
Cellular Component | late endosome | |
Cellular Component | lysosomal membrane | |
Cellular Component | membrane | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | trans-Golgi network | |
Cellular Component | trans-Golgi network membrane | |
Cellular Component | transport vesicle | |
Molecular Function | protein domain specific binding | |
Molecular Function | protein transporter activity | |
Molecular Function | retromer complex binding | |
Molecular Function | transmembrane signaling receptor activity | |
Biological Process | endosome to lysosome transport | |
Biological Process | glycosphingolipid catabolic process | |
Biological Process | lysosomal transport | |
Biological Process | protein targeting to lysosome | |
Biological Process | receptor-mediated endocytosis | |
Biological Process | secretion of lysosomal enzymes |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCation-dependent mannose-6-phosphate receptor
- Short namesCD Man-6-P receptor; CD-MPR
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP20645
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 27-185 | Lumenal | ||||
Sequence: TEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISH | ||||||
Transmembrane | 186-210 | Helical | ||||
Sequence: LSVGSILLVTFASLVAVYVVGGFLY | ||||||
Topological domain | 211-277 | Cytoplasmic | ||||
Sequence: QRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 259 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-26 | UniProt | |||||
Sequence: MFPFYSCWRTGLLLLLLAVAVRESWQ | |||||||
Chain | PRO_0000019226 | 27-277 | UniProt | Cation-dependent mannose-6-phosphate receptor | |||
Sequence: TEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM | |||||||
Disulfide bond | 32↔78 | UniProt | |||||
Sequence: CDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVC | |||||||
Glycosylation | 57 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 83 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 94 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 107 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 113 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 132↔167 | UniProt | |||||
Sequence: CGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDC | |||||||
Disulfide bond | 145↔179 | UniProt | |||||
Sequence: CNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLAC | |||||||
Modified residue | 267 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 267 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Homodimer. Binds GGA1, GGA2 and GGA3.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P20645 | COMT P21964-2 | 3 | EBI-2907262, EBI-10200977 | |
BINARY | P20645 | DUSP12 Q9UNI6 | 3 | EBI-2907262, EBI-715161 | |
BINARY | P20645 | GGA3 Q9NZ52 | 2 | EBI-2907262, EBI-447404 | |
BINARY | P20645 | GIMAP5 Q96F15 | 3 | EBI-2907262, EBI-6166686 | |
BINARY | P20645 | KTN1 Q86UP2-3 | 3 | EBI-2907262, EBI-12007212 | |
BINARY | P20645 | NINJ2 Q9NZG7 | 3 | EBI-2907262, EBI-10317425 | |
BINARY | P20645 | SMCO4 Q9NRQ5 | 3 | EBI-2907262, EBI-8640191 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 30-181 | MRH | ||||
Sequence: KTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSP | ||||||
Region | 256-277 | Disordered | ||||
Sequence: RGVGDDQLGEESEERDDHLLPM |
Domain
The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length277
- Mass (Da)30,993
- Last updated1991-02-01 v1
- Checksum1093FE25DEB6C8E8
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M16985 EMBL· GenBank· DDBJ | AAA59542.1 EMBL· GenBank· DDBJ | mRNA | ||
X56254 EMBL· GenBank· DDBJ | CAB94715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X56255 EMBL· GenBank· DDBJ | CAB94715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X56256 EMBL· GenBank· DDBJ | CAB94715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X56257 EMBL· GenBank· DDBJ | CAB94715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK291143 EMBL· GenBank· DDBJ | BAF83832.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471116 EMBL· GenBank· DDBJ | EAW88596.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471116 EMBL· GenBank· DDBJ | EAW88597.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471116 EMBL· GenBank· DDBJ | EAW88598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471116 EMBL· GenBank· DDBJ | EAW88599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC024206 EMBL· GenBank· DDBJ | AAH24206.1 EMBL· GenBank· DDBJ | mRNA |