P20311 · DPOL_BPT3

Function

function

Replicates viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'-5' direction.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

170450100150200250300350400450500550600650700
TypeIDPosition(s)Description
Binding site5Mg2+ 1 (UniProtKB | ChEBI); catalytic; for 3'-5' exonuclease activity
Binding site5Mg2+ 2 (UniProtKB | ChEBI); catalytic; for 3'-5' exonuclease activity
Binding site7Mg2+ 2 (UniProtKB | ChEBI); catalytic; for 3'-5' exonuclease activity
Binding site174Mg2+ 2 (UniProtKB | ChEBI); catalytic; for 3'-5' exonuclease activity
Binding site475Mg2+ 3 (UniProtKB | ChEBI); catalytic; for polymerase activity
Binding site475Mg2+ 4 (UniProtKB | ChEBI); catalytic; for polymerase activity
Binding site476Mg2+ 4 (UniProtKB | ChEBI); catalytic; for polymerase activity
Binding site506substrate
Binding site518substrate
Binding site522substrate
Binding site526substrate
Binding site654Mg2+ 3 (UniProtKB | ChEBI); catalytic; for polymerase activity
Binding site654Mg2+ 4 (UniProtKB | ChEBI); catalytic; for polymerase activity

GO annotations

AspectTerm
Molecular Function3'-5' exonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Biological ProcessDNA-templated DNA replication
Biological Processdouble-strand break repair
Biological Processviral DNA genome replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed DNA polymerase
  • EC number
  • Alternative names
    • Gene product 5 (Gp5)

Gene names

    • Name
      5

Organism names

Accessions

  • Primary accession
    P20311

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001012681-704DNA-directed DNA polymerase

Interaction

Subunit

Composed of two subunits. One is encoded by the phage and the other is encoded by the host thioredoxin.

Structure

3D structure databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-1873'-5'exonuclease
Region202-704Polymerase

Sequence similarities

Belongs to the DNA polymerase type-A family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    704
  • Mass (Da)
    79,985
  • Last updated
    1991-02-01 v1
  • Checksum
    D65DFBD99AE31234
MLVSDIEANNLLEKVTKFHCGVIYDYRDGEYHSYRPGDFGAYLDALEAEVKRGGLIVFHNGHKYDVPALTKLAKLQLNREFHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGKRFGSHALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTFWSESLEAVDVEHRAAWLLAKQERNGFPFDTKAIEELYVELAARRSELLRNLTETFGSWYQPKGGTEMFCHPRTGKPLPKYPRIKIPKVGGIFKKPKNKAQREGREPCELDTREYVAGAPYTPVEHVVFNPSSRDHIQKKLQEAGWVPTKFTDKGAPVVDDEVLEGVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCRAAFGAEHHLDGITGKPWVQAGIDASGLELRCLAHFMARFDNGEYAHEILNGDIHTKNQMAAELPTRDNAKTFIYGFLYGAGDEKIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQTLVESSQWVAGEQQVKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICKLWIIKTEEMLVEKGLKHGWDGDFAYMAWIHDEIQVACRTEEIAKTVIEVAQEAMRWVGEHWNFRCLLDTEGKMGANWKECH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X17255
EMBL· GenBank· DDBJ
CAA35140.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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