P20193 · SUV37_DROME

Function

function

Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentheterochromatin
Cellular Componentnucleus
Cellular Componentpericentric heterochromatin
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Biological Processdosage compensation by hyperactivation of X chromosome
Biological Processpositive regulation of heterochromatin formation
Biological Processpositive regulation of pericentric heterochromatin formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein suppressor of variegation 3-7

Gene names

    • Name
      Su(var)3-7
    • Synonyms
      Suvar(3)7
    • ORF names
      CG8599

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P20193
  • Secondary accessions
    • Q9VFX7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000470601-1250Protein suppressor of variegation 3-7
Modified residue165Phosphoserine
Modified residue175Phosphoserine
Modified residue176Phosphoserine
Modified residue871Phosphoserine
Modified residue873Phosphoserine
Modified residue975Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with Su(var)39 through the BESS domain.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, zinc finger, domain.

TypeIDPosition(s)Description
Region107-148Disordered
Compositional bias115-133Basic and acidic residues
Region160-186Disordered
Zinc finger217-236C2H2-type 1
Zinc finger319-343C2H2-type 2
Region343-398Disordered
Compositional bias372-386Basic and acidic residues
Zinc finger425-446C2H2-type 3
Zinc finger487-512C2H2-type 4
Region525-564Disordered
Zinc finger605-629C2H2-type 5
Region642-684Disordered
Compositional bias660-680Acidic residues
Zinc finger737-761C2H2-type 6
Zinc finger829-852C2H2-type 7
Region851-915Disordered
Compositional bias866-881Polar residues
Compositional bias882-896Basic and acidic residues
Domain987-1026BESS
Compositional bias1032-1057Polar residues
Region1032-1060Disordered
Region1079-1116Disordered
Region1154-1180Disordered
Region1205-1236Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,250
  • Mass (Da)
    139,990
  • Last updated
    2004-07-19 v4
  • Checksum
    90D0338C894D074C
MDRDSSMQAKNLDAQCNPDLKMASANSETLASATHELKIMDVEGGALVDPDHIEEVETSMVIVVDDDDGDVAMVVEEDKHPMRDDPCIEDIMDDEHAPLVAELQSALNNPDDKQASEDPLLEDQEREPDAMSTKTEPSSDAESSHSYHDPMGLLERIEIHDPGDSQDDDDEDDESSNGGGVDGGMRRKMPRAQRWLLWMKRWPWILHEDSDGTLAFCLYCNISINVNNRSRHIQQHNVSLSHQERECNYLAFKKSEEETRGAISDNEIKHEFGTKSYVAAMKQKRISETEAFNNFNWLRWLRWHPWLERSMPTGTIGTCRICSVRMNVEFVYLRKRHETTKGHMEALRNLDSDKRSRKRKRSKSNSVTNSGGDEAEREKESEPEVGPEDAQDTPVVMMNGDVDSGDDPGKWCALIPDTNPQQCRCTLCNCTMAITSFLRHCKTRAHCHMLSTPAEKGSSDIRGIWAVFADMHPWLIADPEDPSIGYCSVCRKRFMYGNSEIKRKNHEKSEKHTLALASAKAGIEVGSADGRGGDNMDEEEAAASDQAQSSQTDDSEDNDDDNWSEIQKLGKGFAHKSSSEPRKATVRAGVRFYPWLCYSKDRKTQICKFCRVRFHNEAAKARHELSARHVKLVKQFKMRQAKLHQGTNTQTKHNAQDDEESQEQDEEYGEEEEDAEEDSQSNFDLGTVQARKTARADNKLFVKPIPATMKGKVMVWKGRFPWLSYKKNEQRGNYAWCKLCEVSLYLPSSKWASKHQRTSRHIRLRIDRKRNGGNPLKTSNKNSGEISTVVATASALASAEARQKAAMAELQAKYDWLDPDANDENHCHCRVCDSRLPIKVFYLRQHDASRKHVENKERQRANAAAAANAPSVSPTSTVDAERQESGMDKESENDMSVRSDGSTAEPLAKRSRRSMEVRRIIRALRDSMGKRQEERSQMDMARDMICSSFDIVTRLRTLERESVAHNESMAQAPPSVTVSPIKPPEPRHVMDLFFDSISPTMKSLPPDLAAEGKSKIMQLVCSLELRAMQRNATTPTPATVSASSKWPSSTTVTPVKTPPAPISAPLASVDADLHSSVVTTPHEYNNGQNNNNDKETVPKEPVTGASSAQVTINGSAKDLPENIRRILTSNQTQVTNRLETDSVRCVPLDKLTTQSRTNVNGRLSQGGTSEAPSTPQADLSNGNTLAMIRQIRVNNNNSSKITVTNTPQMQQPQQAQASITSSTPIMRGGPSSNGCQITTFRTMVNHNRRP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E1JIJ9E1JIJ9_DROMESu(var)3-71248

Sequence caution

The sequence CAA36434.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict53-54in Ref. 1; CAA36434
Compositional bias115-133Basic and acidic residues
Sequence conflict265in Ref. 1; CAA36434
Compositional bias372-386Basic and acidic residues
Sequence conflict385in Ref. 1; CAA36434
Compositional bias660-680Acidic residues
Compositional bias866-881Polar residues
Compositional bias882-896Basic and acidic residues
Sequence conflict943in Ref. 1; CAA36434
Compositional bias1032-1057Polar residues
Sequence conflict1148in Ref. 1; CAA36434
Sequence conflict1159in Ref. 1; CAA36434
Sequence conflict1193in Ref. 1; CAA36434

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X52187
EMBL· GenBank· DDBJ
CAA36434.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AE014297
EMBL· GenBank· DDBJ
AAF54918.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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