P20181 · NTF3_MOUSE
- ProteinNeurotrophin-3
- GeneNtf3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids258 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P20181
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
Suppressed kindling epileptogenesis and perturbed BDNF and TrkB gene regulation in NT-3 mutant mice.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
BDNF is required for the normal development of taste neurons in vivo.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Neurotrophin-3 is a survival factor in vivo for early mouse trigeminal neurons.
- CategoriesFunction, Expression, Phenotypes & Variants
- SourceMGI: 97380
Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Most classes of dorsal root ganglion neurons are severely depleted but not absent in mice lacking neurotrophin-3.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
- PubMed
- Europe PMC
- Int J Dev Biol 39:799-807 ()
Mapped toDependence of developing group Ia afferents on neurotrophin-3.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
Role of neurotrophins in mouse neuronal development.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
Targeted disruption of the neurotrophin-3 gene with lacZ induces loss of trkC-positive neurons in sensory ganglia but not in spinal cords.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
Complementary roles of BDNF and NT-3 in vestibular and auditory development.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
Mapped toThe dependence receptor TrkC regulates the number of sensory neurons during DRG development.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97380
Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors.
- CategoryPhenotypes & Variants
- SourceMGI: 97380
Mapped toInner ear hair cells deteriorate in mice engineered to have no or diminished innervation.
- CategoryPhenotypes & Variants
- SourceMGI: 97380