P20122 · 1A_CMVO

Function

function

Involved in the virus replication. Contains a helicase domain and a methyltransferase domain. The methyltransferase domain is probably involved in viral RNA capping. Involved in the formation of ER membrane spherular invaginations in which RNA replication complexes form (By similarity).

Features

Showing features for binding site.

1993100200300400500600700800900
TypeIDPosition(s)Description
Binding site714-721ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides
Molecular FunctionmRNA methyltransferase activity
Molecular FunctionRNA binding
Biological Processmethylation
Biological ProcessmRNA modification
Biological ProcessRNA processing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Replication protein 1a

Including 2 domains:

Gene names

    • ORF names
      ORF1a

Organism names

Accessions

  • Primary accession
    P20122

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000832621-993Replication protein 1a

Interaction

Subunit

Interacts with RNA-directed RNA polymerase 2a.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region50-409Methyltransferase
Domain72-290Alphavirus-like MT
Region537-565Disordered
Domain687-838+RNA virus helicase ATP-binding
Region712-975ATP-dependent helicase
Domain839-993+RNA virus helicase C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    993
  • Mass (Da)
    111,266
  • Last updated
    1991-02-01 v1
  • Checksum
    8FDEC1F3C66EBB4C
MATSSFNINELVASHGDKGLLATALVDKAAHEQLEEQLQHQRRGRKVYVRNVLSVKDSEVIRNRYGGKYDLHLTQQEFAPHGLAGALRLCETLDCLDSFPSSGLRQDLVLDFGGSWVTHYLRGHNVHCCSPCLGIRDKMRHTERLMNMRKIILNDPQQFDGRQPDFCTHPAADCKVQAHFAISIHGGYDMGFRGLCEAMNAHGTTILKGTMMFDGAMMFDDQGIIPELNCQWRKIRNAFSETEDVTPLVGKLNSTVFSRVRKFKTLVAFDFINESTMSYVHDWENIKSFLTDQTYSYKGMTYGIERCVINAGIMTYKIIGVPGMCPPELIRHCIWFPSIKDYVGLKIPASQDLVEWKTVRILTSTLRETEEIAMRCYNDKKAWMEQFKVILGVLSAKSSTIVINGMSMQSGERIDINDYHYIGFAILLHTKMKYEQLGKMYDMWNASSISKWFAALTRPVRVFFSSAVHALFPTLRPREEKEFLIKLSTFVTFNEECSFDGGEEWDVISSAAYVATQAVTDGKVLAAQKAEKLAEKLAQPVDEVSDSPEVPSSTPDDTADVCGKEQEVSELDSLSAQTRSPITRVAERATAMLEYAAYEKQLHDTTVSNLKRIWNMAGGDDKRNSLEGNLKFVFDTYFTVDPMVNIHFSTGRWMRPVPEGIVYSVGYNERGLGPKSDGELFIVNSECVICNSESLSAVTRSLQAPTGTISQVDGVAGCGKTTAIKSIFEPSTDMIVTANKKSAQDVRMALFKSSDSKEACAFVRTADSVLLNECPTVSRVLVDEVVLLHFGQLCAVMSKLKAVRAICFGDSEQIAFSSRDASFDMRFSKIIPDETSDADTTFRSPQDVVPLVRLMATKALPKGTHSKYTKWVSQSKVKRSVTSRSIASVTLVDLDSSRFYITMTQADKASLISRAKEMNLPKTFWNERIKTVHESQGISEDHVTLVRLKSTKCDLFKQFSYCLVALTRHKVTFRYEYCGVLNGDLIAECIARA

Sequence databases

Similar Proteins

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