P20081 · FKBP_YEAST
- ProteinFK506-binding protein 1
- GeneFPR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids114 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Miscellaneous
Binds to the immunosuppressant drug FK506 and also mediates the sensitivity to rapamycin (PubMed:1996117).
Rapamycin disrupts interaction with FAP1
Rapamycin disrupts interaction with FAP1
Present with 43300 molecules/cell in log phase SD medium.
Catalytic activity
- [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | macrolide binding | |
Molecular Function | peptidyl-prolyl cis-trans isomerase activity | |
Molecular Function | protein folding chaperone | |
Biological Process | chromatin organization | |
Biological Process | nonfunctional rRNA decay | |
Biological Process | protein folding | |
Biological Process | regulation of chaperone-mediated protein folding | |
Biological Process | regulation of homoserine biosynthetic process | |
Biological Process | transcription by RNA polymerase II |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFK506-binding protein 1
- Short namesFKBP
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP20081
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 43 | Reduces interaction with FAP1. | |||
Mutagenesis | 44 | Abrogates interaction with FAP1. | |||
Mutagenesis | 48 | Abrogates interaction with FAP1. | |||
Mutagenesis | 49 | Abrogates interaction with FAP1. | |||
Mutagenesis | 94 | Abrogates interaction with FAP1. | |||
Mutagenesis | 106 | Reduces interaction with FAP1. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylserine | |||
Chain | PRO_0000075305 | 2-114 | FK506-binding protein 1 | ||
Modified residue | 51 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with HMO1. Interacts with FAP1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P20081 | BUD27 P43573 | 2 | EBI-6961, EBI-22787 | |
BINARY | P20081 | HOM3 P10869 | 4 | EBI-6961, EBI-2430 | |
XENO | P20081 | TOR Q9FR53 | 3 | EBI-6961, EBI-1382370 | |
BINARY | P20081 | TOR1 P35169 | 4 | EBI-6961, EBI-19374 | |
BINARY | P20081 | TOR2 P32600 | 3 | EBI-6961, EBI-19385 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 26-114 | PPIase FKBP-type | |||
Sequence similarities
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length114
- Mass (Da)12,158
- Last updated1991-05-01 v2
- Checksum65C134830D300C06
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z46843 EMBL· GenBank· DDBJ | CAA86890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M57967 EMBL· GenBank· DDBJ | AAA03564.1 EMBL· GenBank· DDBJ | Unassigned DNA | ||
M60877 EMBL· GenBank· DDBJ | AAA34607.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M63892 EMBL· GenBank· DDBJ | AAA34962.1 EMBL· GenBank· DDBJ | mRNA | ||
Z71411 EMBL· GenBank· DDBJ | CAA96017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY557997 EMBL· GenBank· DDBJ | AAS56323.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006947 EMBL· GenBank· DDBJ | DAA10413.1 EMBL· GenBank· DDBJ | Genomic DNA |