P20059 · HEMO_RAT

Function

function

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Miscellaneous

The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).

Features

Showing features for binding site.

146050100150200250300350400450
TypeIDPosition(s)Description
Binding site79Fe (UniProtKB | ChEBI) of heme 1 (UniProtKB | ChEBI); axial binding residue
Binding site149Fe (UniProtKB | ChEBI) of heme 1 (UniProtKB | ChEBI); axial binding residue
Binding site235Fe (UniProtKB | ChEBI) of heme 2 (UniProtKB | ChEBI); axial binding residue
Binding site291Fe (UniProtKB | ChEBI) of heme 2 (UniProtKB | ChEBI); axial binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionheme transmembrane transporter activity
Molecular Functionmetal ion binding
Biological Processheme metabolic process
Biological Processhemoglobin metabolic process
Biological Processintracellular iron ion homeostasis
Biological Processpositive regulation of humoral immune response mediated by circulating immunoglobulin
Biological Processpositive regulation of immunoglobulin production
Biological Processpositive regulation of response to type II interferon
Biological Processpositive regulation of type II interferon-mediated signaling pathway
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processregulation of protein metabolic process
Biological Processtype II interferon-mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hemopexin

Gene names

    • Name
      Hpx

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P20059
  • Secondary accessions
    • Q5BKB4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_000002141024-460Hemopexin
Glycosylation38N-linked (GlcNAc...) asparagine
Disulfide bond50↔230
Glycosylation64N-linked (GlcNAc...) asparagine
Disulfide bond148↔153
Glycosylation186N-linked (GlcNAc...) asparagine
Disulfide bond187↔199
Glycosylation240N-linked (GlcNAc...) asparagine
Glycosylation246N-linked (GlcNAc...) asparagine
Disulfide bond255↔458
Disulfide bond364↔406
Disulfide bond416↔433

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed by the liver and secreted in plasma.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat53-93Hemopexin 1
Repeat94-138Hemopexin 2
Repeat139-183Hemopexin 3
Repeat184-230Hemopexin 4
Repeat257-302Hemopexin 5
Repeat303-350Hemopexin 6
Repeat355-394Hemopexin 7
Repeat398-448Hemopexin 8

Sequence similarities

Belongs to the hemopexin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    460
  • Mass (Da)
    51,351
  • Last updated
    2007-01-09 v3
  • Checksum
    508963FEE0E31D92
MARTVVALNILVLLGLCWSLAVANPLPAAHETVAKGENGTKPDSDVIEHCSDAWSFDATTMDHNGTMLFFKGEFVWRGHSGIRELISERWKNPVTSVDAAFRGPDSVFLIKEDKVWVYPPEKKENGYPKLFQEEFPGIPYPPDAAVECHRGECQSEGVLFFQGNRKWFWDFATRTQKERSWPAVGNCTAALRWLERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFISCPGRGHGKLRNGTAHGNSTHPMHSRCNADPGLSALLSDHRGATYAFSGSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSWDEKVYLIQGTQVYVFLTKGGNNLVSGYPKRLEKELGSPPGISLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQATWAELSWPHEKVDGALCLEKSLGPYSCSSNGPNLFFIHGPNLYCYSSIDKLNAAKSLPQPQKVNSILGCSQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict38in Ref. 4; AA sequence
Sequence conflict49-50in Ref. 4; AA sequence
Sequence conflict135in Ref. 1; AAA41337

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M62642
EMBL· GenBank· DDBJ
AAA41337.1
EMBL· GenBank· DDBJ
Genomic DNA
X60006
EMBL· GenBank· DDBJ
CAA42621.1
EMBL· GenBank· DDBJ
Genomic DNA
BC091137
EMBL· GenBank· DDBJ
AAH91137.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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