P19919 · DCML_AFIC5
- ProteinCarbon monoxide dehydrogenase large chain
- GenecoxL
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids809 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the oxidation of carbon monoxide to carbon dioxide.
Catalytic activity
- a quinone + CO + H2O = a quinol + CO2
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Cu+ ion per subunit.
Note: Binds 1 Mo-molybdopterin cytosine dinucleotide (Mo-MCD) cofactor per subunit.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
16.4 μM | 1,4-benzoquinone |
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | carbon-monoxide dehydrogenase (acceptor) activity | |
Molecular Function | carbon-monoxide oxygenase activity | |
Molecular Function | copper ion binding | |
Molecular Function | iron ion binding | |
Molecular Function | molybdenum ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarbon monoxide dehydrogenase large chain
- EC number
- Short namesCO dehydrogenase subunit L; CO-DH L
Gene names
Encoded on
- Plasmid megaplasmid pHCG3
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Afipia
Accessions
- Primary accessionP19919
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000079810 | 1-809 | Carbon monoxide dehydrogenase large chain | |||
Sequence: MNIQTTVEPTSAERAEKLQGMGCKRKRVEDIRFTQGKGNYVDDVKLPGMLFGDFVRSSHAHARIKSIDTSKAKALPGVFAVLTAADLKPLNLHYMPTLAGDVQAVLADEKVLFQNQEVAFVVAKDRYVAADAIELVEVDYEPLPVLVDPFKAMEPDAPLLREDIKDKMTGAHGARKHHNHIFRWEIGDKEGTDATFAKAEVVSKDMFTYHRVHPSPLETCQCVASMDKIKGELTLWGTFQAPHVIRTVVSLISGLPEHKIHVIAPDIGGGFGNKVGAYSGYVCAVVASIVLGVPVKWVEDRMENLSTTSFARDYHMTTELAATKDGKILAMRCHVLADHGAFDACADPSKWPAGFMNICTGSYDMPVAHLAVDGVYTNKASGGVAYRCSFRVTEAVYAIERAIETLAQRLEMDSADLRIKNFIQPEQFPYMAPLGWEYDSGNYPLAMKKAMDTVGYHQLRAEQKAKQEAFKRGETREIMGIGISFFTEIVGAGPSKNCDILGVSMFDSAEIRIHPTGSVIARMGTKSQGQGHETTYAQIIATELGIPADDIMIEEGNTDTAPYGLGTYGSRSTPTAGAATAVAARKIKAKAQMIAAHMLEVHEGDLEWDVDRFRVKGLPEKFKTMKELAWASYNSPPPNLEPGLEAVNYYDPPNMTYPFGAYFCIMDIDVDTGVAKTRRFYALDDCGTRINPMIIEGQVHGGLTEAFAVAMGQEIRYDEQGNVLGASFMDFFLPTAVETPKWETDYTVTPSPHHPIGAKGVGESPHVGGVPCFSNAVNDAYAFLNAGHIQMPHDAWRLWKVGEQLGLHV |
Interaction
Subunit
Dimer of heterotrimers. Each heterotrimer consists of a large, a medium and a small subunit.
Structure
Sequence
- Sequence statusComplete
- Length809
- Mass (Da)88,739
- Last updated2002-07-11 v2
- Checksum7F2F3D0EC996BDBD
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 6 | in Ref. 4; AA sequence | ||||
Sequence: Missing | ||||||
Sequence conflict | 11-12 | in Ref. 4; AA sequence | ||||
Sequence: SA → AG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002827 EMBL· GenBank· DDBJ | AEI08106.1 EMBL· GenBank· DDBJ | Genomic DNA |